Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Endothelin receptor ET-B | Starlite/ChEMBL | References |
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Endothelin receptor ET-B | 443 aa | 392 aa | 23.5 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Onchocerca volvulus | Endothelin receptor ET-B | 443 aa | 371 aa | 20.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0035 | 0.0059 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0111 | 0.0198 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.1032 | 0.5443 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.1891 | 1 | 0.5 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.1032 | 0.5443 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.1032 | 0.5443 | 0.5437 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1891 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0111 | 0.0099 |
Onchocerca volvulus | 0.0029 | 0.0121 | 0.001 | |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1891 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0111 | 0.0198 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.1032 | 0.5443 | 0.5437 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0111 | 0.0099 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.0296 | 0.0538 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.1032 | 0.5443 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.1032 | 0.5443 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0035 | 0.0059 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.1032 | 0.5443 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0043 | 0.0031 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.1032 | 0.5443 | 0.5437 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0121 | 0.0216 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1891 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.1032 | 0.5443 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0121 | 0.0108 |
Schistosoma mansoni | lamin | 0.0028 | 0.0111 | 0.0198 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1891 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0111 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0035 | 0.0023 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.1891 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0109 | 0.0096 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.1032 | 0.5443 | 0.5443 |
Echinococcus granulosus | lamin | 0.0028 | 0.0111 | 0.0198 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0111 | 0.0198 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.1891 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.1032 | 0.5443 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.013 | 0.0232 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.013 | 0.0232 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0111 | 0.0099 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0013 | 0.0018 |
Echinococcus granulosus | dnaJ subfamily B | 0.0419 | 0.2191 | 0.4021 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0033 | 0.002 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0121 | 0.0109 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1891 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1891 | 1 | 1 |
Onchocerca volvulus | 0.1891 | 1 | 1 | |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.1032 | 0.5443 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.013 | 0.0232 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0111 | 0.0198 |
Schistosoma mansoni | lamin | 0.0028 | 0.0111 | 0.0198 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0111 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0111 | 0.0099 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.1032 | 0.5443 | 0.5443 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1891 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.013 | 0.0232 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.1032 | 0.5443 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0419 | 0.2191 | 0.4021 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.1891 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0043 | 0.003 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0419 | 0.2191 | 0.4021 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.1032 | 0.5443 | 0.5437 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1891 | 1 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.1032 | 0.5443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0033 | 0.002 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0111 | 0.0198 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0013 | 0.0018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.58 nM | Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cells | ChEMBL. | 11985472 |
IC50 (binding) | = 0.58 nM | Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cells | ChEMBL. | 11985472 |
IC50 (binding) | = 46 nM | Binding affinity to endothelin B receptor measured by inhibition of [125I]-ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells | ChEMBL. | 11985472 |
IC50 (binding) | = 46 nM | Binding affinity to endothelin B receptor measured by inhibition of [125I]-ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells | ChEMBL. | 11985472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.