TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.431 | Formula: C20H25N3O3
H donors: 1 H acceptors: 2 LogP: 4.12 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O/N=C(/c1ccc(nc1)Oc1cccc(c1)OC)\N1CC(C)CC(C1)C
InChi: 1S/C20H25N3O3/c1-14-9-15(2)13-23(12-14)20(22-24)16-7-8-19(21-11-16)26-18-6-4-5-17(10-18)25-3/h4-8,10-11,14-15,24H,9,12-13H2,1-3H3/b22-20-
InChiKey: WVQVAIGKNDNAOT-XDOYNYLZSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0029	0.0107	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0073	0.6213
Chlamydia trachomatis	DNA gyrase subunit B	0.0029	0.0107	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0187	0.1911
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.005	0.0068
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0043	0.0229	0.7743
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0009	0.082
Brugia malayi	CHE-14 protein	0.0045	0.0245	0.0556
Schistosoma mansoni	importin beta-1	0.0031	0.0121	0.0274
Echinococcus granulosus	heat shock protein	0.0029	0.0107	0.0243
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0029	0.0107	0.0107
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.0766	0.1736
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0029	0.0107	0.0243
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0051	0.0296	0.0671
Trichomonas vaginalis	heat shock protein, putative	0.0029	0.0107	0.292
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0245	0.0556
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0073
Entamoeba histolytica	hypothetical protein	0.0025	0.007	0.028
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0029	0.0107	0.292
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0211	0.1701	0.1701
Schistosoma mansoni	DNA topoisomerase II	0.0029	0.0107	0.0243
Trichomonas vaginalis	receptor histidine kinase, putative	0.0029	0.0107	0.292
Leishmania major	hypothetical protein, conserved	0.0029	0.0107	0.0243
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0029	0.0107	0.292
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0182	0.1447	0.328
Mycobacterium ulcerans	two component sensor kinase MprB	0.0029	0.0107	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0073	0.0166
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0182	0.1447	0.328
Schistosoma mansoni	hypothetical protein	0.0043	0.0231	0.0524
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0018	0.1657
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0073	0.0166
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0029	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0018
Leishmania major	importin beta-1 subunit, putative	0.0025	0.007	0.0159
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0018
Schistosoma mansoni	heat shock protein	0.0029	0.0107	0.0243
Chlamydia trachomatis	DNA gyrase subunit B	0.0029	0.0107	1
Trichomonas vaginalis	heat shock protein, putative	0.0029	0.0107	0.292
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0522	0.4413	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0522	0.4413	1
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0245	0.0333
Toxoplasma gondii	mitochondrial inner membrane translocase subunit TIM17, putative	0.0043	0.0229	0.0229
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0073	0.6213
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.6213
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0187	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0107	0.0107
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.007	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0018
Plasmodium falciparum	importin beta, putative	0.0031	0.0121	0.4081
Leishmania major	GTP-binding protein, putative	0.0023	0.005	0.0114
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0121	0.0274
Schistosoma mansoni	hypothetical protein	0.0021	0.0035	0.0079
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0029	0.0107	1
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0029	0.0107	1
Trypanosoma brucei	DNA topoisomerase ii	0.0029	0.0107	0.0243
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.005	0.0114
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.096	0.096
Echinococcus multilocularis	heat shock protein	0.0029	0.0107	0.0145
Schistosoma mansoni	hypothetical protein	0.0043	0.0229	0.052
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0029	0.0107	1
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0029	0.0107	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0121	0.0274
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0029	0.0107	1
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0301	0.0408
Brugia malayi	hypothetical protein	0.0039	0.0193	0.0437
Schistosoma mansoni	heat shock protein	0.0029	0.0107	0.0243
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0029	0.0107	1
Plasmodium vivax	DNA topoisomerase II, putative	0.0029	0.0107	0.3619
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.096	0.096
Plasmodium vivax	endoplasmin, putative	0.0029	0.0107	0.3619
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0029	0.0107	1
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.0766	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0029	0.0107	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0073	0.6841
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0107	0.3619
Entamoeba histolytica	hypothetical protein	0.0038	0.0187	0.1911
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0043	0.0229	0.0311
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0029	0.0107	0.0243
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0029	0.0107	0.292
Loa Loa (eye worm)	TOPoisomerase family member	0.0029	0.0107	0.0107
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0029	0.0107	0.0243
Trypanosoma brucei	heat shock protein 90, putative	0.0029	0.0107	0.0243
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.005	0.1698
Schistosoma mansoni	ran	0.0023	0.005	0.0114
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0029	0.0107	0.5
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0029	0.0107	1
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0029	0.0107	1
Trichomonas vaginalis	sensor histidine kinase, putative	0.0029	0.0107	0.292
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.005	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0766	0.0766
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0121	0.0274
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0121	0.4081
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0029	0.0107	0.292
Echinococcus multilocularis	snurportin 1	0.0326	0.2707	0.3673
Loa Loa (eye worm)	heat shock protein 90	0.0029	0.0107	0.0107
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.005	0.005
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0029	0.0107	1
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0187	0.0254
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0029	0.0107	0.0107
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0029	0.0107	0.0243
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0073	0.0166
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.086	0.737	1
Mycobacterium leprae	Probable two-component sensor kinase	0.0029	0.0107	1
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0029	0.0107	0.0243
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0051	0.0296	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0073	0.6213
Schistosoma mansoni	patched 1	0.0045	0.0245	0.0556
Schistosoma mansoni	hypothetical protein	0.0043	0.0231	0.0524
Loa Loa (eye worm)	hypothetical protein	0.1161	1	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0493	0.4159	0.9425
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0245	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.6213
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0107	0.0107
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0073	0.0322
Plasmodium vivax	DNA gyrase subunit B, putative	0.0029	0.0107	0.3619
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.005	0.0114
Trichomonas vaginalis	endoplasmin, putative	0.0029	0.0107	0.292
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0073	0.0166
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.007	0.1027
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0029	0.0107	1
Brugia malayi	MH2 domain containing protein	0.0127	0.096	0.2176
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0043	0.0229	0.7743
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.005	0.005
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0522	0.4413	1
Schistosoma mansoni	hypothetical protein	0.0326	0.2707	0.6134
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0043	0.0229	0.052
Brugia malayi	Importin beta-1 subunit	0.0031	0.0121	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0073
Trypanosoma cruzi	heat shock protein 90, putative	0.0029	0.0107	0.0243
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.1158	0.1571
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0051	0.0296	0.0296
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0245	0.0245
Brugia malayi	heat shock protein 90	0.0029	0.0107	0.0243
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0073	0.6213
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0029	0.0107	1
Plasmodium falciparum	endoplasmin, putative	0.0029	0.0107	0.3619
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0029	0.0107	0.0145
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0029	0.0107	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.0766	0.1736
Trypanosoma brucei	Heat shock protein 83, putative	0.0029	0.0107	0.0243
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0029	0.0107	0.0107
Giardia lamblia	Pms1-like protein	0.0029	0.0107	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.078	0.1768
Trypanosoma cruzi	heat shock protein 85, putative	0.0029	0.0107	0.0243
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0029	0.0107	1
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0029	0.0107	0.5
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0018	0.06
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0051	0.0296	0.0671
Schistosoma mansoni	endoplasmin	0.0029	0.0107	0.0243
Brugia malayi	RNA, U transporter 1	0.0087	0.0614	0.1391
Echinococcus multilocularis	heat shock protein 90	0.0029	0.0107	0.0145
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0043	0.0229	0.052
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0029	0.0107	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.6213
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0245	0.0245
Trypanosoma cruzi	heat shock protein 90, putative	0.0029	0.0107	0.0243
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Toxoplasma gondii	TIM10 family protein, putative	0.0051	0.0296	0.0296
Schistosoma mansoni	pyruvate dehydrogenase	0.0493	0.4159	0.9425
Trypanosoma cruzi	heat shock protein 85, putative	0.0029	0.0107	0.0243
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0029	0.0107	0.0243
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0073	0.6213
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.007	0.1027
Entamoeba histolytica	heat shock protein 90, putative	0.0029	0.0107	0.0795
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0029	0.0107	0.5
Plasmodium falciparum	heat shock protein 90	0.0029	0.0107	0.3619
Plasmodium falciparum	DNA topoisomerase 2	0.0029	0.0107	0.3619
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Loa Loa (eye worm)	endoplasmin	0.0029	0.0107	0.0107
Entamoeba histolytica	hypothetical protein	0.0038	0.0187	0.1911
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0522	0.4413	0.5988
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0018
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Entamoeba histolytica	DNA topoisomerase II, putative	0.0029	0.0107	0.0795
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0073	0.0322
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0029	0.0107	0.292
Leishmania major	mitochondrial DNA topoisomerase II	0.0029	0.0107	0.0243
Echinococcus multilocularis	expressed protein	0.0051	0.0296	0.0402
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0029	0.0107	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0187	0.1911
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0522	0.4413	1
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0182	0.1447	0.328
Echinococcus granulosus	snurportin 1	0.0326	0.2707	0.6134
Leishmania major	DNA topoisomerase ii	0.0029	0.0107	0.0243
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0029	0.0107	1
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0182	0.1447	0.1447
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0009	0.082
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0073	0.6841
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0029	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4413	0.4413
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0029	0.0107	0.0243
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Loa Loa (eye worm)	hypothetical protein	0.1161	1	1
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0018	0.06
Toxoplasma gondii	heat shock protein HSP90	0.0029	0.0107	0.0107
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0029	0.0107	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0187	0.0424
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0245	0.0556
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0029	0.0107	0.0243
Brugia malayi	Probable DNA topoisomerase II	0.0029	0.0107	0.0243
Brugia malayi	kinase, mitochondrial precursor	0.0522	0.4413	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.0766	0.104
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0051	0.0296	1
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Schistosoma mansoni	hypothetical protein	0.0043	0.0231	0.0524
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0073	0.0322
Echinococcus granulosus	expressed conserved protein	0.0098	0.0711	0.1611
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0029	0.0107	1
Trypanosoma brucei	heat shock protein, putative	0.0029	0.0107	0.0243
Toxoplasma gondii	heat shock protein 90, putative	0.0029	0.0107	0.0107
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Brugia malayi	hypothetical protein	0.0038	0.0187	0.0424
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0029	0.0107	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0187	0.0424
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.005	0.1698
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0029	0.0107	1
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0029	0.0107	1
Schistosoma mansoni	endoplasmin	0.0029	0.0107	0.0243
Trichomonas vaginalis	receptor histidine kinase, putative	0.0029	0.0107	0.292
Entamoeba histolytica	heat shock protein 90, putative	0.0029	0.0107	0.0795
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0029	0.0107	0.5
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0121	0.0164
Echinococcus granulosus	heat shock protein 90	0.0029	0.0107	0.0243
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.1161	1	1
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0029	0.0107	0.0243
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0029	0.0107	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0073
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.005	0.0114
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0029	0.0107	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0326	0.2707	0.2707
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0051	0.0296	0.0296
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0029	0.0107	0.0243
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0029	0.0107	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0073	0.0166
Brugia malayi	hypothetical protein	0.0039	0.0193	0.0437
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0009	0.082
Mycobacterium ulcerans	DNA gyrase subunit B	0.0029	0.0107	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.005	0.0114
Leishmania major	heat shock protein 83-1	0.0029	0.0107	0.0243
Plasmodium falciparum	DNA gyrase subunit B	0.0029	0.0107	0.3619
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.1158	0.2624
Echinococcus granulosus	expressed protein	0.0051	0.0296	0.0671
Mycobacterium tuberculosis	Conserved protein	0.0029	0.0107	1
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0029	0.0107	1
Schistosoma mansoni	ran	0.0023	0.005	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0018
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0029	0.0107	0.292
Mycobacterium ulcerans	putative regultory protein	0.0029	0.0107	1
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0043	0.0229	0.052
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0029	0.0107	0.3619
Toxoplasma gondii	hypothetical protein	0.1161	1	1
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0522	0.4413	0.5988
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0009	0.082
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0073	0.0166
Schistosoma mansoni	hypothetical protein	0.0043	0.0231	0.0524
Trypanosoma brucei	heat shock protein 90, putative	0.0029	0.0107	0.0243
Trypanosoma cruzi	Heat shock protein 83, putative	0.0029	0.0107	0.0243
Plasmodium vivax	heat shock protein 86, putative	0.0029	0.0107	0.3619
Echinococcus multilocularis	protein patched	0.0045	0.0245	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0333	0.0333
Trypanosoma cruzi	heat shock protein 85, putative	0.0029	0.0107	0.0243
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0029	0.0107	0.0243
Echinococcus multilocularis	expressed conserved protein	0.0098	0.0711	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0121	0.0121
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.007	0.0159
Brugia malayi	Endoplasmin precursor	0.0029	0.0107	0.0243
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0029	0.0107	1
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0522	0.4413	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -7 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1859622

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1056490