Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0677 | 0.5937 | 0.5937 |
Loa Loa (eye worm) | carboxylesterase | 0.0188 | 0.1339 | 0.1339 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0188 | 0.1339 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | carboxylesterase | 0.111 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0679 | 0.0679 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | neuroligin | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | acetylcholinesterase | 0.111 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Brugia malayi | Carboxylesterase family protein | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0188 | 0.1339 | 0.1339 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0188 | 0.1339 | 0.1339 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Brugia malayi | Carboxylesterase family protein | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0677 | 0.5937 | 0.5937 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0188 | 0.1339 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | carboxylesterase 5A | 0.111 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0188 | 0.1339 | 0.1339 |
Brugia malayi | Carboxylesterase family protein | 0.0188 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.111 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0188 | 0.1339 | 0.5 |
Onchocerca volvulus | 0.0188 | 0.1339 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Schistosoma mansoni | gliotactin | 0.0188 | 0.1339 | 0.1339 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Echinococcus multilocularis | acetylcholinesterase | 0.111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.111 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.111 | 1 | 1 |
Onchocerca volvulus | 0.0188 | 0.1339 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0188 | 0.1339 | 0.1339 |
Onchocerca volvulus | 0.0188 | 0.1339 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.111 | 1 | 1 |
Onchocerca volvulus | 0.0188 | 0.1339 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0188 | 0.1339 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0188 | 0.1339 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.111 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0188 | 0.1339 | 0.5 |
Brugia malayi | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | acetylcholinesterase | 0.111 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0188 | 0.1339 | 0.1339 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0677 | 0.5937 | 0.5937 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0679 | 0.0679 |
Echinococcus multilocularis | acetylcholinesterase | 0.111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Schistosoma mansoni | acetylcholinesterase | 0.0188 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1339 | 0.1339 |
Onchocerca volvulus | 0.0188 | 0.1339 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0188 | 0.1339 | 0.1339 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0188 | 0.1339 | 0.1339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | Antibacterial activity against Escherichia coli ATCC 44752 at 100 ug/disk after 24 hrs by disk diffusion method | ChEMBL. | 19144450 | |
IZ (functional) | Antibacterial activity against Escherichia coli ATCC 44752 at 200 ug/disk after 24 hrs by disk diffusion method | ChEMBL. | 19144450 | |
IZ (functional) | Antibacterial activity against Escherichia coli ATCC 44752 at 50 ug/disk after 24 hrs by disk diffusion method | ChEMBL. | 19144450 | |
IZ (functional) | = 18 mm | Antifungal activity against Candida albicans ATCC 10231 at 50 ug/disk after 24 hrs by disk diffusion method | ChEMBL. | 19144450 |
IZ (functional) | = 21 mm | Antifungal activity against Candida albicans ATCC 10231 at 100 ug/disk after 24 hrs by disk diffusion method | ChEMBL. | 19144450 |
IZ (functional) | = 24 mm | Antifungal activity against Candida albicans ATCC 10231 at 200 ug/disk after 24 hrs by disk diffusion method | ChEMBL. | 19144450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.