Detailed information for compound 105830

Basic information

Technical information
  • TDR Targets ID: 105830
  • Name: N-benzyl-1-methoxy-6-phenyl-6H-benzo[c]chrome n-8-amine
  • MW: 393.477 | Formula: C27H23NO2
  • H donors: 1 H acceptors: 0 LogP: 6.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1c1ccc(cc1C(O2)c1ccccc1)NCc1ccccc1
  • InChi: 1S/C27H23NO2/c1-29-24-13-8-14-25-26(24)22-16-15-21(28-18-19-9-4-2-5-10-19)17-23(22)27(30-25)20-11-6-3-7-12-20/h2-17,27-28H,18H2,1H3
  • InChiKey: MUDXDMDYMQNFQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-benzyl-1-methoxy-6-phenyl-6H-benzo[c][1]benzopyran-8-amine
  • 1-methoxy-6-phenyl-N-(phenylmethyl)-6H-benzo[c]chromen-8-amine
  • benzyl-(1-methoxy-6-phenyl-6H-benzo[c]chromen-8-yl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclins 0.0088 0.105 0.2758
Brugia malayi ecdysteroid receptor 0.0009 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0933 0.2449
Toxoplasma gondii hypothetical protein 0.0067 0.0785 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0933 0.2455
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0148
Echinococcus granulosus Cyclin L1 0.0021 0.0215 0.0558
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0933 0.2455
Echinococcus granulosus g protein coupled receptor 0.0079 0.0933 0.2449
Echinococcus granulosus cyclin t1 0.0021 0.0215 0.0558
Onchocerca volvulus 0.0079 0.0933 0.4711
Onchocerca volvulus 0.0079 0.0933 0.4711
Schistosoma mansoni ferritin light chain 0.0008 0.0054 0.0142
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0003 0.0007
Trichomonas vaginalis cyclin B3, putative 0.0088 0.105 0.524
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0.0933 0.2455
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0063 0.0159
Schistosoma mansoni amine GPCR 0.0079 0.0933 0.2455
Trichomonas vaginalis cyclins, putative 0.0163 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0.0933 0.2449
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0163 0.1977 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0063 0.006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0.0933 0.093
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0.0933 0.2449
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0.0933 0.093
Schistosoma mansoni cyclin G 0.0021 0.0215 0.0565
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0037 0.0035
Schistosoma mansoni cyclin B3 0.0309 0.38 1
Schistosoma mansoni biogenic amine receptor 0.0079 0.0933 0.2455
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus somatostatin receptor 0.0079 0.0933 0.2449
Trypanosoma brucei mitotic cyclin 6 0.0163 0.1977 1
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi nuclear hormone receptor 0.0009 0.0063 0.0159
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0933 0.2449
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0933 0.2449
Echinococcus granulosus cyclins 0.0088 0.105 0.2758
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0933 0.2449
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0493 0.1581
Schistosoma mansoni amine GPCR 0.0079 0.0933 0.2455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0063 0.0159
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0215 0.0558
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Echinococcus granulosus cyclin A3 4 0.0021 0.0215 0.0558
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0933 0.2449
Trichomonas vaginalis cyclins, putative 0.0163 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni opsin-like receptor 0.0079 0.0933 0.2455
Echinococcus granulosus cyclin b3 0.0088 0.105 0.2758
Echinococcus granulosus cyclin y 0.0021 0.0215 0.0558
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0148
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0933 0.093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0063 0.0159
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0933 0.093
Trichomonas vaginalis cyclin B, putative 0.0163 0.1977 1
Trichomonas vaginalis cyclins, putative 0.0096 0.1142 0.571
Onchocerca volvulus Protein CNPPD1 homolog 0.0021 0.0215 0.1073
Echinococcus granulosus cyclins 0.0021 0.0215 0.0558
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0933 0.093
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0.0933 0.093
Onchocerca volvulus 0.0079 0.0933 0.4711
Brugia malayi cyclin fold protein 1 variant b 0.0021 0.0215 0.0558
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni hypothetical protein 0.0021 0.0215 0.0565
Trichomonas vaginalis cyclins, putative 0.0021 0.0215 0.095
Echinococcus granulosus neuropeptide receptor A26 0.0079 0.0933 0.2449
Onchocerca volvulus 0.0021 0.0215 0.1073
Brugia malayi ORL1-like opioid receptor 0.0079 0.0933 0.2449
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0493 0.1292
Entamoeba histolytica cyclin family protein 0.0088 0.105 0.4741
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0.0933 0.093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0009 0.0024
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0.0933 0.2449
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0063 0.0166
Brugia malayi GnHR receptor homolog 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni ferritin 0.0008 0.0054 0.0142
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0063 0.0166
Schistosoma mansoni apoferritin-2 0.0008 0.0054 0.0142
Loa Loa (eye worm) hypothetical protein 0.0074 0.0876 0.2299
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0.0933 0.2455
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0054 0.5
Brugia malayi hypothetical protein 0.0021 0.0215 0.0558
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0309 0.38 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0305 0.0796
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0054 0.5
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0493 0.1292
Loa Loa (eye worm) CYL-1 protein 0.0021 0.0215 0.0558
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis G1:S specific cyclin D1 0.0021 0.0215 0.0212
Echinococcus granulosus cyclin G2 0.0021 0.0215 0.0558
Leishmania major cyclin 0.0163 0.1977 1
Plasmodium falciparum cyclin 0.0088 0.105 1
Onchocerca volvulus 0.0029 0.0305 0.153
Echinococcus multilocularis cyclin A3 4 0.0021 0.0215 0.0212
Brugia malayi G-protein coupled receptor 0.0079 0.0933 0.2449
Echinococcus granulosus cyclin 0.0021 0.0215 0.0558
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0.0933 0.2455
Loa Loa (eye worm) hypothetical protein 0.0043 0.0488 0.1277
Onchocerca volvulus 0.0079 0.0933 0.4711
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0021 0.0215 0.0558
Echinococcus multilocularis cyclin G2 0.0021 0.0215 0.0212
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0.0933 0.4711
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0009 0.0017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0558
Brugia malayi Melatonin receptor type 1A 0.0079 0.0933 0.2449
Echinococcus granulosus neuropeptide receptor 0.0079 0.0933 0.2449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0063 0.0159
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0215 0.0558
Trichomonas vaginalis cyclin B, putative 0.0021 0.0215 0.095
Echinococcus multilocularis cyclin t1 0.0021 0.0215 0.0212
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi Protein kinase domain containing protein 0.0044 0.0493 0.1292
Echinococcus multilocularis cyclin B 0.0163 0.1977 0.1975
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0063 0.0159
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0021 0.0215 0.0558
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0054 0.5
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0037 0.0091
Trichomonas vaginalis cyclin B, putative 0.0021 0.0215 0.095
Echinococcus granulosus cyclins 0.0088 0.105 0.2758
Echinococcus multilocularis cyclin k 0.0021 0.0215 0.0212
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0.0933 0.2449
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0933 0.093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus allatostatin A receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis Cyclin L1 0.0021 0.0215 0.0212
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0063 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0063 0.0159
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0.0933 0.093
Echinococcus multilocularis g-protein coupled receptor 0.0079 0.0933 0.093
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0021 0.0215 0.0565
Brugia malayi AKH receptor 0.0079 0.0933 0.2449
Brugia malayi Dopamine receptor protein 1 0.0079 0.0933 0.2449
Echinococcus multilocularis neuropeptide receptor A26 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0021 0.0215 0.0212
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0063 0.0305
Schistosoma mansoni cpg binding protein 0.003 0.0325 0.0856
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0063 0.0159
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0493 0.1581
Onchocerca volvulus 0.0079 0.0933 0.4711
Echinococcus granulosus cyclins 0.0088 0.105 0.2758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0063 0.0159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0933 0.2449
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Echinococcus multilocularis cyclin b3 0.0088 0.105 0.1048
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0054 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0063 0.0159
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0933 0.2455
Trichomonas vaginalis cyclin B, putative 0.0163 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Trichomonas vaginalis ferritin, putative 0.0008 0.0054 0.0125
Brugia malayi sulfakinin receptor protein 0.0079 0.0933 0.2449
Brugia malayi RE15519p 0.0079 0.0933 0.2449
Schistosoma mansoni cpg binding protein 0.003 0.0325 0.0856
Echinococcus granulosus fmrfamide receptor 0.0079 0.0933 0.2449
Brugia malayi Dopamine receptor protein 2 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0933 0.2449
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0933 0.2449
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0215 0.095
Schistosoma mansoni cpg binding protein 0.0029 0.0305 0.0802
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0.0933 0.093
Echinococcus granulosus g protein coupled receptor 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0017
Trichomonas vaginalis cyclin B, putative 0.0088 0.105 0.524
Echinococcus granulosus cyclins 0.0088 0.105 0.2758
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0.0933 0.093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Schistosoma mansoni hypothetical protein 0.0079 0.0933 0.2455
Echinococcus multilocularis somatostatin receptor 0.0079 0.0933 0.093
Brugia malayi Cyclin, N-terminal domain containing protein 0.0163 0.1977 0.52
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus G1:S specific cyclin D1 0.0021 0.0215 0.0558
Brugia malayi larval opioid receptor 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0009 0.0017
Schistosoma mansoni nuclear receptor nhr-48 0.0004 0.0003 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0933 0.093
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0.0933 0.2449
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0003 0.0007
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0493 0.0491
Echinococcus granulosus neuropeptide receptor 0.0079 0.0933 0.2449
Echinococcus granulosus cyclin B3 1 0.0088 0.105 0.2758
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0493 0.1581
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0063 0.0166
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0063 0.0305
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0063 0.0159
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0933 0.2449
Brugia malayi neuropeptide F receptor 0.0079 0.0933 0.2449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Schistosoma mansoni ferritin 0.0008 0.0054 0.0142
Trichomonas vaginalis cyclins, putative 0.0163 0.1977 1
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni ferritin light chain 0.0008 0.0054 0.0142
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0054 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0933 0.2455
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0933 0.093
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0.0933 0.2455
Schistosoma mansoni nuclear receptor 0.0004 0.0003 0.0007
Schistosoma mansoni cyclins 0.0088 0.105 0.2764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0063 0.0159
Entamoeba histolytica cyclin, putative 0.0163 0.1977 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0037 0.0098
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni cyclin G2 0.0021 0.0215 0.0565
Schistosoma mansoni apoferritin-2 0.0008 0.0054 0.0142
Brugia malayi steroid hormone receptor 0.0009 0.0063 0.0159
Onchocerca volvulus 0.0079 0.0933 0.4711
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0063 0.0166
Trichomonas vaginalis cyclin A, putative 0.0163 0.1977 1
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0021 0.0215 0.0212
Echinococcus multilocularis allatostatin A receptor 0.0079 0.0933 0.093
Trichomonas vaginalis cyclin D, putative 0.0088 0.105 0.524
Schistosoma mansoni histamine h1 receptor 0.0079 0.0933 0.2455
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0054 0.5
Trichomonas vaginalis cyclins, putative 0.0163 0.1977 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0215 0.095
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0215 0.095
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Trichomonas vaginalis cyclins, putative 0.0021 0.0215 0.095
Trichomonas vaginalis cyclins, putative 0.0088 0.105 0.524
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0933 0.2449
Schistosoma mansoni amine GPCR 0.0079 0.0933 0.2455
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Onchocerca volvulus 0.0079 0.0933 0.4711
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0933 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0063 0.0159
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0933 0.2449
Schistosoma mansoni ferritin 0.0008 0.0054 0.0142
Giardia lamblia Cyclin A 0.0088 0.105 0.4741
Trichomonas vaginalis cyclin B, putative 0.0163 0.1977 1
Echinococcus granulosus orexin receptor type 2 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni biogenic amine receptor 0.0079 0.0933 0.2455
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0493 0.1292
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus multilocularis cyclin 0.0021 0.0215 0.0212
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0063 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0063 0.0159
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0493 0.0491
Schistosoma mansoni amine GPCR 0.0079 0.0933 0.2455
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0.0933 0.2449
Trichomonas vaginalis cyclin D, putative 0.0088 0.105 0.524
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0063 0.0159
Schistosoma mansoni ferritin 0.0008 0.0054 0.0142
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0063 0.006
Onchocerca volvulus 0.0079 0.0933 0.4711
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0933 0.2449
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0063 0.0159
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0.0933 0.2449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0063 0.006
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0493 0.1581
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0.0933 0.093
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0493 0.2381
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0063 0.0159
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0.0933 0.2449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0017
Schistosoma mansoni Cyclin fold protein 0.0021 0.0215 0.0565
Loa Loa (eye worm) cyclin domain-containing protein 0.0309 0.38 1
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0021 0.0215 0.0558
Onchocerca volvulus 0.0163 0.1977 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0.0933 0.2449
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.105 0.524
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0.0933 0.2449
Echinococcus granulosus hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi hypothetical protein 0.0021 0.0215 0.0558
Schistosoma mansoni neuropeptide receptor 0.0079 0.0933 0.2455
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0009 0.0017
Trypanosoma cruzi CYC2-like cyclin, putative 0.0163 0.1977 1
Schistosoma mansoni nuclear receptor 0.0004 0.0003 0.0007
Onchocerca volvulus 0.0079 0.0933 0.4711
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0493 0.1292
Schistosoma mansoni neuropeptide receptor 0.0079 0.0933 0.2455
Echinococcus granulosus ferritin 0.0008 0.0054 0.0135
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0063 0.0159
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0.0933 0.2455
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0933 0.093
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0009 0.0024
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0493 0.0491
Schistosoma mansoni opsin-like receptor 0.0079 0.0933 0.2455
Echinococcus multilocularis cyclin y 0.0021 0.0215 0.0212
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0063 0.0159
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0063 0.0166
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0493 0.1292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0493 0.1581
Trichomonas vaginalis cyclin B3, putative 0.0021 0.0215 0.095
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0063 0.0159
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0004 0.0003 0.0007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Schistosoma mansoni hypothetical protein 0.0021 0.0215 0.0565
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0063 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0063 0.0159
Brugia malayi neuropeptide F receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0063 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0493 0.2381
Echinococcus granulosus G protein coupled receptor 139 0.0079 0.0933 0.2449
Schistosoma mansoni zinc finger protein 0.0004 0.0003 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0933 0.2455
Echinococcus granulosus g-protein coupled receptor 0.0079 0.0933 0.2449
Schistosoma mansoni cyclin d 0.0021 0.0215 0.0565
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Schistosoma mansoni myosin xvIII 0.0079 0.0933 0.2455
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0063 0.0159
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0.0933 0.2455
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Brugia malayi putative neuropeptide receptor 0.0079 0.0933 0.2449
Echinococcus granulosus cyclin G2 0.0021 0.0215 0.0558
Echinococcus multilocularis serotonin receptor 0.0079 0.0933 0.093
Onchocerca volvulus Cyclin L homolog 0.0021 0.0215 0.1073
Schistosoma mansoni coup transcription factor 0.0009 0.0063 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0063 0.0159
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0063 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0056
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Echinococcus multilocularis ferritin 0.0008 0.0054 0.0051
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0493 0.1581
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0215 0.0558
Onchocerca volvulus 0.0079 0.0933 0.4711
Loa Loa (eye worm) cyclin C 0.0021 0.0215 0.0558
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0493 0.1292
Plasmodium vivax protein kinase Crk2 0.0044 0.0493 1
Schistosoma mansoni cyclin B 0.0163 0.1977 0.5203
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0.0933 0.2449
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0063 0.0159
Brugia malayi Serotonin receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis serotonin receptor 0.0079 0.0933 0.093
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0.0933 0.2449
Entamoeba histolytica cyclin family protein 0.0088 0.105 0.4741
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Echinococcus granulosus cyclin B 0.0163 0.1977 0.52
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0493 0.1581
Brugia malayi cell division control protein 2 homolog 0.0044 0.0493 0.1292
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0933 0.093
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Echinococcus multilocularis expressed protein 0.0008 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0017
Echinococcus multilocularis cpg binding protein 0.003 0.0325 0.0323
Trichomonas vaginalis cyclin A, putative 0.0021 0.0215 0.095
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0493 0.1581
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0305 0.0796
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Onchocerca volvulus 0.0079 0.0933 0.4711
Onchocerca volvulus 0.0079 0.0933 0.4711
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0704 0.1853
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0037 0.0091
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0215 0.0558
Echinococcus granulosus cyclin k 0.0021 0.0215 0.0558
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Loa Loa (eye worm) TYRA-2 protein 0.0079 0.0933 0.2449
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0054 0.5
Trichomonas vaginalis cyclin D, putative 0.0021 0.0215 0.095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Onchocerca volvulus 0.0009 0.0063 0.0305
Schistosoma mansoni amine GPCR 0.0079 0.0933 0.2455
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0063 0.0159
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0.0933 0.093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0063 0.0305
Schistosoma mansoni neuropeptide receptor 0.0079 0.0933 0.2455
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0058 0.0145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Echinococcus multilocularis neuropeptide s receptor 0.0079 0.0933 0.093
Trichomonas vaginalis cyclin B, putative 0.0163 0.1977 1
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0933 0.093
Trypanosoma cruzi cyclin, putative 0.0163 0.1977 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0063 0.0166
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0493 0.1581
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0017
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0.0933 0.2455
Echinococcus granulosus cyclin y 0.0021 0.0215 0.0558
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0.0933 0.4711
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0933 0.093
Brugia malayi Cyclin, N-terminal domain containing protein 0.0309 0.38 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0063 0.0159
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0.0933 0.2449
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0309 0.38 0.3798
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0493 0.1581
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0493 0.1292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Brugia malayi Serotonin receptor 0.0079 0.0933 0.2449
Trichomonas vaginalis cyclin B3, putative 0.0021 0.0215 0.095
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0.0933 0.2449
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0933 0.093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Schistosoma mansoni hypothetical protein 0.0079 0.0933 0.2455
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0933 0.2455
Echinococcus granulosus serotonin receptor 0.0079 0.0933 0.2449
Onchocerca volvulus 0.0079 0.0933 0.4711
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0063 0.0166
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Loa Loa (eye worm) hypothetical protein 0.0163 0.1977 0.52
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0063 0.006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0.0933 0.2449
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0063 0.0159
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0933 0.2455
Brugia malayi Cyclin C 0.0021 0.0215 0.0558
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0.0933 0.2449
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0215 0.0558
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0933 0.093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0933 0.093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni opsin-like receptor 0.0079 0.0933 0.2455
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0493 0.2381
Brugia malayi nuclear receptor RXR 0.0005 0.0009 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0009 0.0017
Brugia malayi G protein-coupled receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0493 0.0491
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0063 0.0166
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Brugia malayi G-protein coupled receptor 0.0079 0.0933 0.2449
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0063 0.0166
Echinococcus granulosus neuropeptide s receptor 0.0079 0.0933 0.2449
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0.0933 0.2449
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0.0933 0.2449
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0933 0.2449
Entamoeba histolytica cyclin, putative 0.0088 0.105 0.4741
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Giardia lamblia Hypothetical protein 0.0088 0.105 0.4741
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0933 0.2455
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0933 0.2455
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0215 0.0558
Brugia malayi Dopamine receptor 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni cyclin l 0.0021 0.0215 0.0565
Brugia malayi follicle stimulating hormone receptor 0.0079 0.0933 0.2449
Echinococcus multilocularis cyclins 0.0088 0.105 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0063 0.0159
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0215 0.0558
Trypanosoma cruzi cyclin, putative 0.0163 0.1977 1
Echinococcus multilocularis orexin receptor type 2 0.0079 0.0933 0.093
Brugia malayi hypothetical protein 0.0005 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0558
Brugia malayi nuclear receptor NHR-88 0.0009 0.0063 0.0159
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0004 0.0003 0.0007
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0493 0.1581
Giardia lamblia G2/mitotic-specific cyclin B 0.0163 0.1977 1
Echinococcus granulosus sex peptide receptor 0.0079 0.0933 0.2449
Echinococcus granulosus cpg binding protein 0.003 0.0325 0.0849
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0623 0.7172
Onchocerca volvulus Cyclin L homolog 0.0021 0.0215 0.1073
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0.0933 0.2449
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0493 0.1581
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0.0933 0.2449
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0.0933 0.2449
Echinococcus multilocularis cyclin y 0.0021 0.0215 0.0212
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0.0933 0.093
Echinococcus multilocularis sex peptide receptor 0.0079 0.0933 0.093
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0.0933 0.2455
Brugia malayi Cyclin, N-terminal domain containing protein 0.0163 0.1977 0.52
Schistosoma mansoni cyclin k 0.0021 0.0215 0.0565
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0037 0.0035
Trypanosoma cruzi cyclin 6, putative 0.0163 0.1977 1
Onchocerca volvulus 0.0079 0.0933 0.4711
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0493 0.4891
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0933 0.2455
Plasmodium falciparum protein kinase 5 0.0044 0.0493 0.3335
Brugia malayi hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni neuropeptide receptor 0.0079 0.0933 0.2455
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0493 0.1298
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Onchocerca volvulus 0.0079 0.0933 0.4711
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0159
Echinococcus granulosus g protein coupled receptor 0.0079 0.0933 0.2449
Schistosoma mansoni adenoreceptor 0.0079 0.0933 0.2455
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0.0933 0.2449
Onchocerca volvulus 0.0079 0.0933 0.4711
Brugia malayi hypothetical protein 0.0005 0.0009 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0063 0.0166
Echinococcus multilocularis cyclin B3 1 0.0088 0.105 0.1048
Echinococcus granulosus expressed protein 0.0008 0.0054 0.0135
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0.0933 0.2449
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0493 0.1298
Schistosoma mansoni biogenic amine receptor 0.0079 0.0933 0.2455
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0.0933 0.2455
Onchocerca volvulus 0.0079 0.0933 0.4711
Loa Loa (eye worm) hypothetical protein 0.0163 0.1977 0.52
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0017
Schistosoma mansoni hypothetical protein 0.0079 0.0933 0.2455
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0063 0.0159
Schistosoma mansoni hypothetical protein 0.0079 0.0933 0.2455
Schistosoma mansoni g1/s-specific cyclin C 0.0021 0.0215 0.0565
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0933 0.2449
Loa Loa (eye worm) hypothetical protein 0.0079 0.0933 0.2449
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0933 0.2449
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0.0933 0.2455
Echinococcus multilocularis cyclin G2 0.0021 0.0215 0.0212
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0.0933 0.2455
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0063 0.0166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0933 0.093
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0215 0.095

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 402 nM Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF) ChEMBL. 15080982
IC50 (functional) = 402 nM Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF) ChEMBL. 15080982
IC50 (binding) = 910 nM Displacement of [3H]-dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 838-988 nM ChEMBL. 15080982
IC50 (binding) = 910 nM Displacement of [3H]-dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 838-988 nM ChEMBL. 15080982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.