Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3891 | 0.7986 | 0.8673 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4459 | 0.9208 | 0.9208 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3891 | 0.7986 | 0.8673 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.1057 | 0.1894 | 0.2057 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0176 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1832 | 0.3561 | 0.3561 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.1832 | 0.3561 | 0.3867 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3891 | 0.7986 | 0.8673 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0176 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2626 | 0.5268 | 0.5268 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0176 | 0 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3167 | 0.6431 | 0.6985 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3338 | 0.6798 | 0.6798 |
Trypanosoma brucei | glucosidase, putative | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3338 | 0.6798 | 0.6798 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Leishmania major | glycosyl hydrolase-like protein | 0.0176 | 0 | 0.5 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3891 | 0.7986 | 0.8673 |
Onchocerca volvulus | 0.1231 | 0.2269 | 0.2464 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3891 | 0.7986 | 0.8673 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2021 | 0.3967 | 0.5 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3891 | 0.7986 | 0.8673 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4827 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Brugia malayi | Ceramide glucosyltransferase | 0.4459 | 0.9208 | 0.9208 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1832 | 0.3561 | 0.3561 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibitory concentration against human cytomegalovirus(HCMV) in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Inhibitory concentration against HCMV in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected monkey kidney cells (BSC-1) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
Inhibition (functional) | = 31 % | Cytotoxicity against human neoplastic cell line(KB cells) | ChEMBL. | 2846837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.