Detailed information for compound 1061597

Basic information

Technical information
  • TDR Targets ID: 1061597
  • Name: (4-methylphenyl)methyl 4-[2-[(4-methylphenyl) methyl]tetrazol-5-yl]benzoate
  • MW: 398.457 | Formula: C24H22N4O2
  • H donors: 0 H acceptors: 4 LogP: 5.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)COC(=O)c1ccc(cc1)c1nnn(n1)Cc1ccc(cc1)C
  • InChi: 1S/C24H22N4O2/c1-17-3-7-19(8-4-17)15-28-26-23(25-27-28)21-11-13-22(14-12-21)24(29)30-16-20-9-5-18(2)6-10-20/h3-14H,15-16H2,1-2H3
  • InChiKey: UQLYRGKVKOLUHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[2-[(4-methylphenyl)methyl]-5-tetrazolyl]benzoic acid (4-methylphenyl)methyl ester
  • 4-[2-(4-methylbenzyl)tetrazol-5-yl]benzoic acid (4-methylbenzyl) ester
  • (4-methylphenyl)methyl 4-[2-[(4-methylphenyl)methyl]-1,2,3,4-tetrazol-5-yl]benzoate
  • A3307/0140536
  • NCGC00102955-01
  • Benzoic acid, 4-[2-(4-methylbenzyl)-2H-tetrazol-5-yl]-, 4-methylbenzyl ester
  • ZINC01080538

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0044 0.004
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0049 0.0049
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0049 0.0049
Plasmodium vivax heat shock protein, putative 0.0183 0.2438 1
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0049 0.0048
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.047 0.4275
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Schistosoma mansoni coup transcription factor 0.0011 0.0044 0.0044
Echinococcus multilocularis protein C ets 2 0.0011 0.0049 0.0049
Brugia malayi Ets-domain containing protein 0.0076 0.0956 0.189
Trypanosoma cruzi heat shock protein 90, putative 0.0048 0.0566 0.5688
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0044 0.0036
Trypanosoma cruzi Heat shock protein 83, putative 0.0048 0.0566 0.5688
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0566 0.5688
Onchocerca volvulus 0.003 0.0316 0.9153
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0788 0.0788
Brugia malayi Ets-domain containing protein 0.0076 0.0956 0.189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Schistosoma mansoni hypothetical protein 0.0031 0.0324 0.0324
Brugia malayi hypothetical protein 0.0027 0.0265 0.0488
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.1739 0.1739
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0049 0.0048
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0044 0.0044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0044 0.0044
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0049 0.0049
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0566 0.5688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0044 0.0036
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0044 0.0044
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0049 0.0048
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0566 1
Brugia malayi hypothetical protein 0.0017 0.0134 0.0223
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Loa Loa (eye worm) endoplasmin 0.0048 0.0566 0.1097
Brugia malayi heat shock protein 90 0.0048 0.0566 0.11
Schistosoma mansoni ets-related 0.0231 0.3115 0.3115
Toxoplasma gondii Hsp90 domain-containing protein 0.0183 0.2438 1
Giardia lamblia Grp94/Hsp90 0.0045 0.0525 0.5748
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0044 0.004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0044 0.0044
Schistosoma mansoni endoplasmin 0.0048 0.0566 0.0566
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0862 0.1697
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0316 0.0589
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0049 0.0051
Echinococcus granulosus heat shock protein 90 0.0048 0.0566 0.0566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0065 0.0802 0.1575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0044 0.0044
Schistosoma mansoni ets 0.0011 0.0049 0.0049
Schistosoma mansoni cpg binding protein 0.003 0.0316 0.0316
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0044 0.0044
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0341 0.0341
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0044 0.004
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0049 0.0049
Brugia malayi nuclear hormone receptor 0.0011 0.0044 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0044 0.0044
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0049 0.0049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0044 0.0044
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0862 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0485
Echinococcus multilocularis endoplasmin 0.0045 0.0525 0.0525
Schistosoma mansoni thyroid hormone receptor 0.0143 0.1887 0.1887
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0566 0.5052
Brugia malayi Temporarily assigned gene name protein 44 0.0031 0.0324 0.0608
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Schistosoma mansoni heat shock protein 0.0032 0.0341 0.0341
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0341 0.1283
Echinococcus granulosus hypothetical protein 0.0031 0.0324 0.0324
Echinococcus multilocularis cpg binding protein 0.0032 0.034 0.034
Brugia malayi Fli-1 protein 0.0231 0.3115 0.6267
Brugia malayi ecdysteroid receptor 0.0011 0.0044 0.004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0044 0.004
Echinococcus multilocularis heat shock protein 90 0.0048 0.0566 0.0566
Schistosoma mansoni microtubule-associated protein tau 0.0726 1 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0049 0.0049
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0049 0.0049
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0049 0.0049
Echinococcus granulosus dnaJ subfamily B 0.043 0.5885 0.5885
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0044 0.0044
Plasmodium vivax endoplasmin, putative 0.0048 0.0566 0.1389
Loa Loa (eye worm) tumor suppressor 0.0364 0.4956 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0044 0.0044
Echinococcus granulosus endoplasmin 0.0045 0.0525 0.0525
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0956 0.0956
Schistosoma mansoni cpg binding protein 0.0032 0.034 0.034
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0862 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Trichomonas vaginalis heat shock protein, putative 0.0041 0.047 0.655
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0286 0.0096
Toxoplasma gondii heat shock protein HSP90 0.0048 0.0566 0.1389
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0044 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0044 0.0036
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0382 0.345
Echinococcus multilocularis protein quaking 0.0031 0.0324 0.0324
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0525 0.8533
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0049 0.0049
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.1887 0.1887
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Leishmania major heat shock protein, putative 0.0032 0.0341 0.1283
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0044 0.0044
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0956 0.0956
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0045 0.0525 0.4362
Loa Loa (eye worm) hypothetical protein 0.0031 0.0324 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0044 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0044 0.004
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0044 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0044 0.0044
Echinococcus granulosus heat shock protein 90 0.0041 0.047 0.047
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.1739 0.1739
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.047 0.4275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0048
Loa Loa (eye worm) fli-1 protein 0.0231 0.3115 0.6265
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0692 0.1967
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0044 0.0044
Schistosoma mansoni gabp alpha 0.0076 0.0956 0.0956
Echinococcus granulosus protein quaking 0.0031 0.0324 0.0324
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0862 1
Echinococcus granulosus heat shock protein 0.0048 0.0566 0.0566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0044 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0044 0.004
Brugia malayi transcription factor E74 isoform 0.0011 0.0049 0.0051
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0862 0.0862
Echinococcus multilocularis dnaJ subfamily B 0.043 0.5885 0.5885
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0044 0.004
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0382 0.345
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0044 0.0044
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0049 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0862 0.0862
Schistosoma mansoni endoplasmin 0.0048 0.0566 0.0566
Schistosoma mansoni elf1 0.0011 0.0049 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0044 0.0044
Echinococcus granulosus protein C ets 2 0.0011 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.043 0.5885 0.5885
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0044 0.0044
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0862 0.1699
Brugia malayi hypothetical protein 0.0031 0.0324 0.0608
Plasmodium vivax heat shock protein 86, putative 0.0048 0.0566 0.1389
Schistosoma mansoni hypothetical protein 0.0192 0.2562 0.2562
Trypanosoma brucei Heat shock protein 83, putative 0.0048 0.0566 0.5052
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0265 0.1286
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0041 0.047 0.047
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0566 0.4324
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0341 0.064
Echinococcus multilocularis heat shock protein 0.0048 0.0566 0.0566
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0044 0.0044
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0045 0.0525 0.5
Echinococcus granulosus geminin 0.0192 0.2562 0.2562
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0862 0.0862
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Brugia malayi CXXC zinc finger family protein 0.003 0.0316 0.0592
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0566 0.4324
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0341 0.2404
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0044 0.0044
Brugia malayi nuclear receptor NHR-88 0.0011 0.0044 0.004
Brugia malayi Endoplasmin precursor 0.0048 0.0566 0.11
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0525 0.8533
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0049 0.0049
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0956 0.1887
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0566 0.5052
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0044 0.004
Schistosoma mansoni hypothetical protein 0.0011 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0012 0.0061 0.0061
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0341 1
Schistosoma mansoni hypothetical protein 0.0192 0.2562 0.2562
Loa Loa (eye worm) heat shock protein 90 0.0048 0.0566 0.1097
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0862 1
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0566 0.5688
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Treponema pallidum heat shock protein 90 0.0045 0.0525 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0862 1
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Plasmodium falciparum endoplasmin, putative 0.0035 0.0382 0.0542
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0044 0.0044
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0049 0.0049
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0044 0.004
Schistosoma mansoni heat shock protein 0.0048 0.0566 0.0566
Schistosoma mansoni hypothetical protein 0.0132 0.1739 0.1739
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0341 0.0353
Echinococcus multilocularis microtubule associated protein 2 0.0726 1 1
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Plasmodium falciparum heat shock protein 90 0.0048 0.0566 0.1389
Brugia malayi tumor suppressor. 0.0364 0.4956 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0048
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0044 0.004
Echinococcus granulosus cpg binding protein 0.0032 0.034 0.034
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0044 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0265 0.1286
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0044 0.0044
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Schistosoma mansoni ets-related 0.0011 0.0049 0.0049
Echinococcus multilocularis geminin 0.0192 0.2562 0.2562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0044 0.0036
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0049 0.0049
Echinococcus granulosus transcription factor Dp 1 0.004 0.0455 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0044 0.004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0044 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0143 0.1887 0.1887
Echinococcus multilocularis heat shock protein 90 0.0041 0.047 0.047
Toxoplasma gondii heat shock protein 90, putative 0.0048 0.0566 0.1389
Giardia lamblia Heat shock protein HSP 90-alpha 0.0048 0.0566 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0044 0.004
Plasmodium falciparum heat shock protein 90, putative 0.0183 0.2438 1
Schistosoma mansoni hypothetical protein 0.0031 0.0324 0.0324
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0049 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0044 0.0036
Trypanosoma brucei heat shock protein, putative 0.0048 0.0566 0.5052
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0045 0.0525 0.5
Brugia malayi Hsp90 protein 0.0032 0.0341 0.0643
Schistosoma mansoni cpg binding protein 0.0032 0.034 0.034
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0455 0.0455
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0045 0.0525 0.5
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0341 0.0353
Leishmania major heat shock protein 83-1 0.0048 0.0566 0.5052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0036
Echinococcus multilocularis ets variant gene 4 0.0011 0.0049 0.0049
Schistosoma mansoni heat shock protein 0.0048 0.0566 0.0566
Schistosoma mansoni hypothetical protein 0.0011 0.0049 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0044 0.0044
Brugia malayi steroid hormone receptor 0.0011 0.0044 0.004
Mycobacterium ulcerans heat shock protein 90 0.0045 0.0525 0.5
Brugia malayi Ets-domain containing protein 0.0011 0.0049 0.0051

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.