Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2573 | 0.4057 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2537 | 0.3997 | 0.4221 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0244 | 0.0182 | 0.0182 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.5676 | 0.922 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.4952 | 0.8016 | 0.8669 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0244 | 0.0182 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.4032 | 0.6485 | 0.6974 |
Schistosoma mansoni | alpha-glucosidase | 0.2537 | 0.3997 | 0.4221 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4249 | 0.6846 | 0.6846 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4249 | 0.6846 | 0.6846 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Schistosoma mansoni | alpha-glucosidase | 0.2537 | 0.3997 | 0.4221 |
Onchocerca volvulus | 0.1704 | 0.2613 | 0.2689 | |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4952 | 0.8016 | 0.8669 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Brugia malayi | Ceramide glucosyltransferase | 0.5676 | 0.922 | 0.9205 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.4952 | 0.8016 | 0.8669 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.6145 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4952 | 0.8016 | 0.8669 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2537 | 0.3997 | 0.4221 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0244 | 0.0182 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.5676 | 0.922 | 0.9205 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.4952 | 0.8016 | 0.8669 |
Leishmania major | glycosyl hydrolase-like protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Echinococcus granulosus | bile acid beta glucosidase | 0.4952 | 0.8016 | 0.8669 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.2537 | 0.3997 | 0.4221 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.2537 | 0.3997 | 0.3886 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.3343 | 0.5339 | 0.5252 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.2537 | 0.3997 | 0.3886 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Bmax1 (binding) | = 49 % | Bmax1 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
Bmax1 (binding) | = 49 % | Bmax1 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
Bmax2 (binding) | = 51 % | Bmax2 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
Bmax2 (binding) | = 51 % | Bmax2 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
IC50 (functional) | = 13.6 nM | Compound was tested for ability to relax potassium-con-tracted rabbit aorta smooth muscle | ChEMBL. | 2834556 |
Kd1 (binding) | = 0.95 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Kd1 (binding) | = 0.95 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Kd2 (binding) | = 74.4 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Kd2 (binding) | = 74.4 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Log 1/EC50 (functional) | = 7.52 | Effective concentration required to produce mechanical response determined in muscle strips of guinea pig | ChEMBL. | 2846838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.