Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4459 | 0.9208 | 0.9208 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3891 | 0.7986 | 0.8673 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.1057 | 0.1894 | 0.2057 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3891 | 0.7986 | 0.8673 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1832 | 0.3561 | 0.3561 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0176 | 0 | 0.5 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0176 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.1832 | 0.3561 | 0.3867 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3891 | 0.7986 | 0.8673 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2626 | 0.5268 | 0.5268 |
Schistosoma mansoni | alpha-glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3338 | 0.6798 | 0.6798 |
Trypanosoma brucei | glucosidase, putative | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Leishmania major | glycosyl hydrolase-like protein | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3338 | 0.6798 | 0.6798 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0176 | 0 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3167 | 0.6431 | 0.6985 |
Onchocerca volvulus | 0.1231 | 0.2269 | 0.2464 | |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3891 | 0.7986 | 0.8673 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0176 | 0 | 0.5 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3891 | 0.7986 | 0.8673 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4827 | 1 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3891 | 0.7986 | 0.8673 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2021 | 0.3967 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Brugia malayi | Ceramide glucosyltransferase | 0.4459 | 0.9208 | 0.9208 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1832 | 0.3561 | 0.3561 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibitory concentration against human cytomegalovirus(HCMV) in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Inhibitory concentration against HCMV in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected monkey kidney cells (BSC-1) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
Inhibition (functional) | > 100 % | Cytotoxicity against human neoplastic cell line(KB cells) | ChEMBL. | 2846837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.