Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.2699 | 0.5 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0098 | 0.2699 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0356 | 0.1071 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0356 | 0.1071 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0356 | 0.0356 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0064 | 0.1266 | 0.3882 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0106 | 0.3067 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0106 | 0.3067 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0356 | 0.1071 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0106 | 0.3067 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0594 | 0.1014 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0773 | 0.266 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0356 | 0.1071 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0106 | 0.3067 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0106 | 0.3067 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0356 | 0.0356 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.101 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0356 | 0.1071 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0773 | 0.266 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.101 | 0.3564 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0356 | 0.1071 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0356 | 0.1071 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0064 | 0.1266 | 0.3355 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0356 | 0.5 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0098 | 0.2699 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0356 | 0.0356 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.2699 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0773 | 0.266 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0594 | 0.1014 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0594 | 0.1977 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0594 | 0.1977 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.2699 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0594 | 0.1977 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0356 | 0.0356 |
Onchocerca volvulus | 0.0042 | 0.0356 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0356 | 0.1071 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0098 | 0.2699 | 1 |
Onchocerca volvulus | 0.0042 | 0.0356 | 0.5 | |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.2699 | 0.5 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0356 | 0.0356 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0098 | 0.2699 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0106 | 0.3067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0356 | 0.1071 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.2699 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0356 | 0.1071 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0594 | 0.1014 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.101 | 0.2791 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0356 | 0.0356 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0356 | 0.1071 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0594 | 0.1977 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0098 | 0.2699 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0594 | 0.1977 |
Onchocerca volvulus | 0.0042 | 0.0356 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0356 | 0.1071 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0106 | 0.3067 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0594 | 0.1014 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0356 | 0.1071 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0098 | 0.2699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0773 | 0.266 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0356 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0356 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.