Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0182 | 0.1266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.0312 | 0.0312 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0182 | 0.1266 | 1 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0556 | 0.4652 | 0.4652 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0069 | 0.0069 |
Onchocerca volvulus | Peroxidase homolog | 0.0076 | 0.0312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.4926 | 0.4926 |
Loa Loa (eye worm) | hypothetical protein | 0.1146 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1146 | 1 | 1 |
Onchocerca volvulus | 0.0076 | 0.0312 | 1 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1146 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0042 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.0312 | 0.0312 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.0312 | 0.0312 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0076 | 0.0312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Brugia malayi | GnHR receptor homolog | 0.1104 | 0.9615 | 0.9615 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0042 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.0312 | 0.0312 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0039 | 0.031 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1104 | 0.6559 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.4652 | 0.4652 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Brugia malayi | Blistered cuticle protein 3 | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0039 | 0.0039 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1104 | 0.6559 |
Echinococcus granulosus | peroxidasin | 0.0076 | 0.0312 | 0.2463 |
Onchocerca volvulus | Peroxidasin homolog | 0.0076 | 0.0312 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0069 | 0.0069 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0076 | 0.0312 | 1 | |
Echinococcus multilocularis | geminin | 0.0164 | 0.1104 | 0.8721 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.0312 | 0.0312 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0593 | 0.499 | 1 |
Onchocerca volvulus | 0.0056 | 0.0127 | 0.4063 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0076 | 0.0312 | 1 |
Schistosoma mansoni | peroxidasin | 0.0076 | 0.0312 | 0.1852 |
Onchocerca volvulus | Peroxidasin homolog | 0.0076 | 0.0312 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0551 | 0.4612 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0056 | 0.0127 | 0.0753 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0593 | 0.499 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0056 | 0.0127 | 0.0753 |
Onchocerca volvulus | Peroxidase homolog | 0.0076 | 0.0312 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0039 | 0.031 |
Onchocerca volvulus | 0.0076 | 0.0312 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0666 | 0.0666 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0666 | 0.0666 |
Schistosoma mansoni | peroxidasin | 0.0076 | 0.0312 | 0.1852 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0056 | 0.0127 | 0.1001 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0556 | 0.4652 | 0.4652 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0666 | 0.0666 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.0312 | 0.0312 |
Echinococcus granulosus | geminin | 0.0164 | 0.1104 | 0.8721 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0056 | 0.0127 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0039 | 0.1257 |
Brugia malayi | Peroxidasin | 0.0076 | 0.0312 | 0.0312 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0312 | 0.0312 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0076 | 0.0312 | 0.0312 |
Echinococcus multilocularis | peroxidasin | 0.0076 | 0.0312 | 0.2463 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0042 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.4652 | 0.4652 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.1683 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0069 | 0.0069 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0039 | 0.0233 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19515562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.