Detailed information for compound 1063307

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.931 | Formula: C22H20ClN3O3S
  • H donors: 1 H acceptors: 1 LogP: 4.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(cccc1OC)CNc1nc2cc(sc2c(=O)n1C)c1cccc(c1)Cl
  • InChi: 1S/C22H20ClN3O3S/c1-26-21(27)20-16(11-18(30-20)13-6-4-8-15(23)10-13)25-22(26)24-12-14-7-5-9-17(28-2)19(14)29-3/h4-11H,12H2,1-3H3,(H,24,25)
  • InChiKey: VUONLWHWSZDJEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus kinase suppressor of Ras 1 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.1756
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0124 0.0317
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Echinococcus granulosus NCK adaptor protein 0.0049 0.2893 0.7398
Onchocerca volvulus 0.0062 0.391 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0014 0.0286 0.0286
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0687 0.1756
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0014 0.0286 0.0732
Brugia malayi integrin-linked kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis tyrosine protein kinase Abl 0.0062 0.391 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0124 0.0124
Echinococcus multilocularis tyrosine protein kinase Blk 0.0062 0.391 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0286 0.0732
Schistosoma mansoni ephrin receptor 0.0014 0.0286 0.0732
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0014 0.0286 0.0286
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/ABL protein kinase 0.0062 0.391 0.391
Echinococcus multilocularis c src tyrosine kinase 0.0062 0.391 1
Brugia malayi ephrin receptor 1 precursor 0.0014 0.0286 0.0286
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0014 0.0286 0.0732
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) protein kinase domain-containing protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0014 0.0286 0.0286
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Toxoplasma gondii protein kinase 0.0014 0.0286 0.5
Echinococcus multilocularis protein kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0014 0.0286 0.0732
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0049 0.2893 0.7398
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0014 0.0286 0.0732
Schistosoma mansoni ephrin receptor 0.0014 0.0286 0.0732
Onchocerca volvulus 0.0062 0.391 1
Brugia malayi Variant SH3 domain containing protein 0.0049 0.2893 0.2893
Echinococcus granulosus SH2 motif 0.0049 0.2893 0.7398
Echinococcus granulosus tyrosine protein kinase Lyn 0.0062 0.391 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0062 0.391 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.391 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0014 0.0286 0.0732
Onchocerca volvulus 0.0062 0.391 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0286 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.391 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0062 0.391 1
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Brugia malayi hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.2026 1
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Onchocerca volvulus 0.0062 0.391 1
Brugia malayi Guanylyl cyclase protein 23 0.0014 0.0286 0.0286
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Schistosoma mansoni hypothetical protein 0.0049 0.2893 0.7398
Echinococcus granulosus suppressor of cytokine signaling 7 0.0049 0.2893 0.7398
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0014 0.0286 0.0732
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.2491 0.6371
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0049 0.2893 0.7398
Brugia malayi Furin-like cysteine rich region family protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.222 0.222
Echinococcus granulosus tyrosine protein kinase Src64B 0.0062 0.391 1
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0687 0.1756
Schistosoma mansoni tyrosine kinase 0.0062 0.391 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.2893 0.7398
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.2893 0.2893
Schistosoma mansoni SH2A 0.0049 0.2893 0.7398
Brugia malayi Variant SH3 domain containing protein 0.0049 0.2893 0.2893
Plasmodium falciparum tyrosine kinase-like protein 0.0014 0.0286 0.5
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0286 0.0732
Onchocerca volvulus 0.0049 0.2893 0.7192
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Brugia malayi SH2 domain containing protein 0.0062 0.391 0.391
Brugia malayi Raf kinase 0.0014 0.0286 0.0286
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0049 0.2893 0.7398
Echinococcus granulosus signal transduction protein lnk realted 0.0049 0.2893 0.7398
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis activated cdc42 kinase 1 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase shark 0.0062 0.391 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.375 0.375
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.222 0.222
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0014 0.0286 0.0732
Giardia lamblia Kinase, NEK 0.0014 0.0286 0.5
Brugia malayi Variant SH3 domain containing protein 0.0049 0.2893 0.2893
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis protein KINase family member (kin 25) 0.0014 0.0286 0.0732
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0049 0.2893 0.7192
Entamoeba histolytica SH2 domain containing protein 0.0049 0.2893 0.7192
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.2893 0.7192
Loa Loa (eye worm) TK/RYK protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0049 0.2893 0.2893
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.1756
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Echinococcus granulosus receptor type guanylyl cyclase 0.0014 0.0286 0.0732
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0687 0.1756
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0049 0.2893 0.7398
Echinococcus granulosus c src tyrosine kinase 0.0062 0.391 1
Schistosoma mansoni growth factor receptor-bound protein 0.0049 0.2893 0.7398
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.222 0.5678
Echinococcus multilocularis receptor type guanylyl cyclase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni serine/threonine RGC 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK protein kinase 0.0062 0.391 0.391
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Echinococcus granulosus SH2 domain containing adapter protein F 0.0049 0.2893 0.7398
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0062 0.391 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0049 0.2893 0.7398
Loa Loa (eye worm) TK/EPH protein kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis N chimaerin 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0049 0.2893 0.7398
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Echinococcus granulosus fibroblast growth factor receptor 4 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0062 0.391 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.2893 0.7398
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0687 0.0687
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.2332 0.2332
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0062 0.391 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0014 0.0286 0.0732
Onchocerca volvulus 0.0049 0.2893 0.7192
Echinococcus granulosus suppressor of cytokine signaling 6 0.0049 0.2893 0.7398
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0286 0.0286
Plasmodium falciparum protein kinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.2893 0.7398
Schistosoma mansoni hypothetical protein 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.2893 0.7398
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0014 0.0286 0.0732
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0124 0.0317
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Echinococcus granulosus hypothetical protein 0.0049 0.2893 0.7398
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus granulosus insulin receptor 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0062 0.391 1
Plasmodium falciparum tyrosine kinase-like protein 0.0014 0.0286 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.391 1
Echinococcus multilocularis 0.0049 0.2893 0.7398
Echinococcus multilocularis tensin 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus granulosus tyrosine kinase 0.0062 0.391 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) STAT protein 0.0049 0.2893 0.2893
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0124 0.0317
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Trypanosoma cruzi protein kinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus activin receptor type 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0062 0.391 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0286 0.5
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis raf serine:threonine protein kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0014 0.0286 0.0732
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0014 0.0286 0.0286
Trypanosoma brucei Flagellum attachment zone protein 20 0.0014 0.0286 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0041 0.2332 0.2332
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0014 0.0286 0.0732
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0049 0.2893 0.7192
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Echinococcus granulosus protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Brugia malayi C-terminal src kinase protein 1 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Echinococcus multilocularis SH2 domain containing protein 7 0.0049 0.2893 0.7398
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Echinococcus granulosus epidermal growth factor receptor 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0062 0.391 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis tyrosine protein kinase HCK 0.0014 0.0286 0.0732
Schistosoma mansoni adapter molecule crk 0.0049 0.2893 0.7398
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0049 0.2893 0.7398
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0014 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.1756
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase shark 0.0062 0.391 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0014 0.0286 0.0286
Echinococcus granulosus protein tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis natriuretic peptide receptor 1 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Onchocerca volvulus 0.0049 0.2893 0.7192
Echinococcus multilocularis protein tyrosine kinase 0.0014 0.0286 0.0732
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0286 0.0286
Brugia malayi Protein kinase domain containing protein 0.0062 0.391 0.391
Echinococcus multilocularis kinase suppressor of Ras 1 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.2893 0.7398
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0687 0.0687
Echinococcus granulosus tyrosine protein kinase Fyn 0.0062 0.391 1
Echinococcus multilocularis SH2 motif 0.0049 0.2893 0.7398
Echinococcus granulosus tyrosine protein kinase Srms 0.0062 0.391 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Brugia malayi bone morphogenetic protein type 1 receptor 0.0014 0.0286 0.0286
Schistosoma mansoni protein tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0124 0.0317
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0049 0.2893 0.7398
Schistosoma mansoni tyrosine kinase 0.0062 0.391 1
Onchocerca volvulus 0.0049 0.2893 0.7192
Plasmodium vivax tyrosine kinase-like protein, putative 0.0014 0.0286 0.5
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0049 0.2893 0.7398
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0286 0.0286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.375 0.375
Leishmania major protein kinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus expressed conserved protein 0.0049 0.2893 0.7398
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0014 0.0286 0.0732
Echinococcus granulosus natriuretic peptide receptor 1 0.0014 0.0286 0.0732
Echinococcus multilocularis tensin 0.0049 0.2893 0.7398
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0062 0.391 1
Trypanosoma brucei protein kinase, putative 0.0014 0.0286 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0062 0.391 1
Echinococcus granulosus SH2 domain containing protein 7 0.0049 0.2893 0.7398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0124
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/ALK protein kinase 0.0014 0.0286 0.0286
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/Met protein kinase 0.0014 0.0286 0.0286
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0062 0.391 0.391
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0014 0.0286 0.0286
Echinococcus granulosus SH2 motif 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0062 0.391 0.391
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Brugia malayi tRNA modification GTPase TrmE family protein 0.0049 0.2893 0.2893
Schistosoma mansoni hypothetical protein 0.0041 0.2332 0.5964
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0286 0.0286
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0687 0.0687
Loa Loa (eye worm) TK/DDR protein kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis transfer RNA-Thr 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0062 0.391 0.391
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0062 0.391 1
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Plasmodium vivax protein kinase, putative 0.0014 0.0286 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) serine/threonine protein kinase 0.0014 0.0286 0.0286
Onchocerca volvulus 0.0062 0.391 1
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Schistosoma mansoni vav2 0.0049 0.2893 0.7398
Echinococcus multilocularis epidermal growth factor receptor 0.0014 0.0286 0.0732
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 1 1
Onchocerca volvulus 0.0049 0.2893 0.7192
Echinococcus multilocularis SH2 motif 0.0049 0.2893 0.7398
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Schistosoma mansoni tyrosine kinase 0.0062 0.391 1
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0124 0.0317
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis tyrosine protein kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase Fyn 0.0062 0.391 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0049 0.2893 0.7398
Echinococcus multilocularis activin receptor type 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0062 0.391 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0014 0.0286 0.0286
Echinococcus multilocularis epidermal growth factor receptor 0.0014 0.0286 0.0732
Brugia malayi Variant SH3 domain containing protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Plasmodium vivax tyrosine kinase-like protein, putative 0.0014 0.0286 0.5
Echinococcus multilocularis protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.2026 1
Onchocerca volvulus 0.0062 0.391 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase pr2 0.0014 0.0286 0.0732
Plasmodium falciparum protein kinase, putative 0.0014 0.0286 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0014 0.0286 0.0286
Echinococcus granulosus tyrosine protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/FAK protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Giardia lamblia Kinase, NEK 0.0014 0.0286 0.5
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis FL cytokine receptor 0.0014 0.0286 0.0732
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0014 0.0286 0.0732
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0049 0.2893 0.7398
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0286 0.0732
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0049 0.2893 0.7398
Loa Loa (eye worm) SRC-1 0.0062 0.391 0.391
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Toxoplasma gondii protein kinase domain-containing protein 0.0014 0.0286 0.5
Echinococcus granulosus tensin 0.0049 0.2893 0.7398
Echinococcus multilocularis heat shock protein 70 0.0014 0.0286 0.0732
Echinococcus granulosus activated cdc42 kinase 1 0.0014 0.0286 0.0732
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Brugia malayi SH2 domain containing protein 0.0062 0.391 0.391
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0014 0.0286 0.0732
Echinococcus multilocularis NCK adaptor protein 0.0049 0.2893 0.7398
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.2893 0.2893
Plasmodium falciparum protein kinase, putative 0.0014 0.0286 0.5
Brugia malayi Protein kinase domain containing protein 0.0062 0.391 0.391
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.2893 0.7398
Loa Loa (eye worm) transcription factor SMAD2 0.0144 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.2491 0.6371
Schistosoma mansoni shc transforming protein 0.0049 0.2893 0.7398
Echinococcus granulosus N chimaerin 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Brugia malayi hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Echinococcus multilocularis SHC transforming protein 3 0.0049 0.2893 0.7398
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0049 0.2893 0.7398
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus granulosus SHC transforming protein 3 0.0049 0.2893 0.7398
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Brugia malayi hypothetical protein 0.0062 0.391 0.391
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Echinococcus multilocularis GPCR, family 2 0.0019 0.0687 0.1756
Echinococcus granulosus raf serine:threonine protein kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0062 0.391 1
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Trypanosoma cruzi protein kinase, putative 0.0014 0.0286 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Echinococcus multilocularis tyrosine protein kinase Srms 0.0062 0.391 1
Onchocerca volvulus 0.0049 0.2893 0.7192
Echinococcus multilocularis insulin receptor 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0014 0.0286 0.0732
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0286 0.0732
Schistosoma mansoni nck2/grb4 0.0049 0.2893 0.7398
Brugia malayi cytokine inducible SH2-containing protein 5 0.0049 0.2893 0.2893
Schistosoma mansoni tyrosine protein kinase 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase Src42A 0.0062 0.391 1
Brugia malayi Tyrosine-protein kinase PR2 0.0014 0.0286 0.0286
Schistosoma mansoni tensin-related 0.0049 0.2893 0.7398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.391 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.375 0.375
Echinococcus granulosus tyrosine protein kinase Fyn 0.0062 0.391 1
Brugia malayi hypothetical protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) TK/ROR protein kinase 0.0014 0.0286 0.0286
Brugia malayi Tyrosine-protein kinase abl-1 0.0062 0.391 0.391
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0049 0.2893 0.7398
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0062 0.391 1
Schistosoma mansoni tensin-related 0.0049 0.2893 0.7398
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0286 0.0732
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Giardia lamblia Protein 21.1 0.0014 0.0286 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0286 0.0732
Toxoplasma gondii STE kinase 0.0014 0.0286 0.5
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0049 0.2893 0.2893
Echinococcus granulosus tyrosine protein kinase ABL1 0.0062 0.391 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Entamoeba histolytica protein kinase, putative 0.0049 0.2893 0.7192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0286
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0049 0.2893 0.2893
Schistosoma mansoni suppressor of cytokine signaling 0.0049 0.2893 0.7398
Echinococcus granulosus activated cdc42 kinase 1 0.0014 0.0286 0.0732
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0049 0.2893 0.7398
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.391 0.391
Schistosoma mansoni tyrosine kinase 0.0062 0.391 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine kinase 0.0062 0.391 1
Schistosoma mansoni protein kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0286 0.0286
Echinococcus multilocularis integrin linked protein kinase 0.0014 0.0286 0.0732
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0124 0.0317
Schistosoma mansoni tensin 0.0049 0.2893 0.7398
Echinococcus granulosus tyrosine protein kinase HCK 0.0014 0.0286 0.0732
Echinococcus granulosus GPCR family 2 0.0019 0.0687 0.1756
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.2893 0.2893
Echinococcus multilocularis ephrin type A receptor 4 A 0.0014 0.0286 0.0732
Echinococcus granulosus integrin linked protein kinase 0.0014 0.0286 0.0732
Brugia malayi RhoGAP domain containing protein 0.0049 0.2893 0.2893
Echinococcus granulosus tyrosine protein kinase pr2 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase Blk 0.0062 0.391 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0014 0.0286 0.0732
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0286 0.0286
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0286 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.375 0.375
Brugia malayi STAT protein, DNA binding domain containing protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0286 0.0732
Brugia malayi SRC-1 0.0062 0.391 0.391
Brugia malayi protein-tyrosine kinase 0.0062 0.391 0.391
Schistosoma mansoni suppressor of cytokine signaling 0.0049 0.2893 0.7398
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Loa Loa (eye worm) TK/ACK protein kinase 0.0014 0.0286 0.0286
Leishmania major hypothetical protein, conserved 0.0014 0.0286 0.5
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Brugia malayi Sex muscle abnormal protein 5 0.0049 0.2893 0.2893
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) hypothetical protein 0.0049 0.2893 0.2893
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0286 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0062 0.391 1
Schistosoma mansoni growth factor receptor-bound protein 0.0049 0.2893 0.7398
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis SH2 motif 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0062 0.391 0.391
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0062 0.391 1
Echinococcus granulosus epidermal growth factor receptor 0.0014 0.0286 0.0732
Schistosoma mansoni signal transduction protein lnk-related 0.0049 0.2893 0.7398
Loa Loa (eye worm) hypothetical protein 0.0034 0.183 0.183
Echinococcus granulosus tyrosine kinase 0.0014 0.0286 0.0732
Loa Loa (eye worm) TK protein kinase 0.0014 0.0286 0.0286
Loa Loa (eye worm) TK/CSK protein kinase 0.0014 0.0286 0.0286
Giardia lamblia Kinase 0.0014 0.0286 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0049 0.2893 0.2893
Schistosoma mansoni tensin 0.0049 0.2893 0.7398
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0014 0.0286 0.0732
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0062 0.391 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0687 0.1756
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0014 0.0286 0.0732
Trypanosoma brucei Pseudokinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0014 0.0286 0.0732
Echinococcus granulosus growth factor receptor bound protein 2 0.0049 0.2893 0.7398
Schistosoma mansoni GTPase activating protein 0.0049 0.2893 0.7398
Brugia malayi Tensin 0.0049 0.2893 0.2893
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0286 0.0732
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0286 0.0732
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0286 0.0732
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.222 0.5678
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0014 0.0286 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0049 0.2893 0.7398
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0062 0.391 1
Schistosoma mansoni tensin 0.0049 0.2893 0.7398
Brugia malayi Protein kinase domain containing protein 0.0014 0.0286 0.0286
Schistosoma mansoni tyrosine kinase 0.0014 0.0286 0.0732
Brugia malayi SH2 domain containing protein 0.0049 0.2893 0.2893
Leishmania major protein kinase, putative 0.0014 0.0286 0.5
Echinococcus granulosus tyrosine kinase 0.0062 0.391 1
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.1756

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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