TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 612.883 | Formula: C37H60N2O5
H donors: 2 H acceptors: 3 LogP: 7.3 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: NCCCNC(=O)[C@@]12CC[C@H]([C@@H]2[C@@H]2[C@](CC1)(C)[C@]1(C)CC[C@@H]3[C@]([C@H]1CC2)(C)CC[C@@H]([C@@]3(C)COC(=O)C)OC(=O)C)C(=C)C
InChi: 1S/C37H60N2O5/c1-23(2)26-12-17-37(32(42)39-21-9-20-38)19-18-35(7)27(31(26)37)10-11-29-33(5)15-14-30(44-25(4)41)34(6,22-43-24(3)40)28(33)13-16-36(29,35)8/h26-31H,1,9-22,38H2,2-8H3,(H,39,42)/t26-,27+,28+,29+,30-,31+,33-,34-,35+,36+,37-/m0/s1
InChiKey: JXXHXJGKRDUIQN-BZMYQMPQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Glycogen phosphorylase, muscle form	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Glycogen phosphorylase, muscle form	843 aa	840 aa	70.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypoxia-induced factor 1	0.0178	0.3806	0.9136
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0751	0.4435
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.2725	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0121	0.2507	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0085	0.1705	0.1607
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.2571
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.2725	0.264
Toxoplasma gondii	thioredoxin reductase	0.0085	0.1694	0.6758
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0029	0.0442	0.054
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.2725	1
Plasmodium vivax	glutathione reductase, putative	0.0085	0.1694	1
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0295	0.0163
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0029	0.0442	0.1444
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0146	0.3087	0.3006
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0121	0.2507	0.4923
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0029	0.0442	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0116	0.026
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0015	0.0116	0.0638
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.067	0.1762
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.2571
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.1052	0.2956
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0029	0.0442	0.1362
Echinococcus granulosus	thioredoxin glutathione reductase	0.0085	0.1705	0.1607
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.1362
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.2725	0.264
Schistosoma mansoni	aryl hydrocarbon receptor	0.0058	0.1079	0.1818
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0029	0.0442	0.5
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0015	0.0116	0.026
Echinococcus granulosus	glycogen phosphorylase	0.013	0.2725	0.264
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.2507	1
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.2725	0.6569
Brugia malayi	bHLH-PAS transcription factor	0.0043	0.0741	0.1305
Echinococcus granulosus	glycogen phosphorylase	0.013	0.2725	0.264
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0145	0.3057	0.7372
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0029	0.0442	0.1444
Brugia malayi	glutathione reductase	0.0085	0.1694	0.3739
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1052	0.3861
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0029	0.0442	0.5
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.2725	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0029	0.0442	0.0847
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0029	0.0442	0.1444
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0442	0.2571
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.2507	0.4241
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0751	0.2434
Mycobacterium ulcerans	putative regulatory protein	0.0043	0.0741	0.1449
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.3057	0.2976
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0116	0.0638
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0009	0.0052
Schistosoma mansoni	glycogen phosphorylase	0.013	0.2725	0.4612
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.2725	0.264
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.067	0.2459
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0029	0.0442	0.1444
Trypanosoma brucei	trypanothione reductase	0.0085	0.1694	1
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0015	0.0116	0.0638
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0231	0.0846
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0231	0.0116
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0751	0.2997
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0029	0.0442	0.1444
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0146	0.3087	0.5227
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0231	0.0116
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0215	0.4636	1
Brugia malayi	hypothetical protein	0.0193	0.4144	1
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0231	0.0116
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0029	0.0442	0.1248
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0029	0.0442	0.1362
Giardia lamblia	Glycogen phosphorylase	0.013	0.2725	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0231	0.092
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.3057	0.2976
Plasmodium falciparum	thioredoxin reductase	0.0029	0.0442	0.1444
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.2725	0.264
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.00000000045124
Schistosoma mansoni	DNA helicase recq1	0.002	0.0231	0.0377
Trypanosoma cruzi	trypanothione reductase, putative	0.0029	0.0442	0.2571
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0145	0.3057	0.7223
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0178	0.3806	0.9182
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0029	0.0442	0.1444
Mycobacterium tuberculosis	Probable oxidoreductase	0.0215	0.4636	1
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0231	0.0438
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0751	0.2997
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.1052	0.3861
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0215	0.4636	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.3057	0.5175
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.2725	1
Brugia malayi	carbohydrate phosphorylase	0.013	0.2725	0.6375
Loa Loa (eye worm)	RecQ helicase	0.002	0.0231	0.0537
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0231	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0193	0.4144	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.067	0.3004
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0085	0.1694	0.2985
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.2507	1
Onchocerca volvulus		0.0043	0.0741	0.2395
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0751	0.0642
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.2571
Brugia malayi	Thioredoxin reductase	0.0085	0.1694	0.3739
Trichomonas vaginalis	mercuric reductase, putative	0.0029	0.0442	0.1248
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.3057	0.2976
Toxoplasma gondii	NADPH-glutathione reductase	0.0029	0.0442	0.1763
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0193	0.4148	0.8837
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0751	0.2434
Plasmodium falciparum	glutathione reductase	0.0029	0.0442	0.1444
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0121	0.2507	1
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0116	0.0638
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.2725	1
Plasmodium falciparum	glutathione reductase	0.0085	0.1694	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0029	0.0442	0.1763
Brugia malayi	acetyltransferase, GNAT family protein	0.0146	0.3087	0.73
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0231	0.1317
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.3057	0.5175
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0537
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0442	0.2571
Loa Loa (eye worm)	glutathione reductase	0.0085	0.1694	0.4075
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0022	0.0266	0.009
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0193	0.4148	0.8921
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0029	0.0442	0.0736
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0231	0.092
Schistosoma mansoni	single-minded	0.0058	0.1079	0.1818
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0295	0.0691
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1052	0.3861
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0029	0.0442	0.2609
Toxoplasma gondii	aldehyde dehydrogenase	0.0121	0.2507	1
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0231	0.0537
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0009	0.0035
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0029	0.0442	0.033
Echinococcus multilocularis	transfer RNA-Lys	0.0043	0.0741	0.0632
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0193	0.4148	0.8837
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.3057	0.2976
Echinococcus granulosus	single minded 2	0.0043	0.0741	0.0632
Schistosoma mansoni	DNA helicase recq5	0.002	0.0231	0.0377
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0142	0.2995	0.2912
Trichomonas vaginalis	glutathione reductase, putative	0.0029	0.0442	0.1248
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0121	0.2507	0.2419
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.1052	0.1455
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.2571
Mycobacterium tuberculosis	Probable reductase	0.0193	0.4148	0.8837
Leishmania major	trypanothione reductase	0.0085	0.1694	0.66
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0029	0.0442	0.033
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.2571
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0231	0.0438
Trypanosoma cruzi	trypanothione reductase, putative	0.0085	0.1694	1
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0231	0.0478
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.2725	1
Loa Loa (eye worm)	acetyltransferase	0.0146	0.3087	0.7445
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.2507	0.4241
Brugia malayi	PAS domain containing protein	0.0058	0.1079	0.2169
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.1052	0.1772
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0009	0.0032
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0121	0.2507	0.2419
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0231	0.0116
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0193	0.4148	0.8837
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.1362
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0215	0.4636	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0015	0.0116	0.0638
Plasmodium vivax	thioredoxin reductase, putative	0.0085	0.1694	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0015	0.0116	0.0638
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0442	0.2571
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0193	0.4148	0.8837
Treponema pallidum	NADH oxidase	0.0029	0.0442	1
Schistosoma mansoni	glycogen phosphorylase	0.013	0.2725	0.4612
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.3057	0.5175
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0231	0.0438
Plasmodium falciparum	thioredoxin reductase	0.0085	0.1694	1
Echinococcus granulosus	bloom syndrome protein	0.002	0.0231	0.0116
Loa Loa (eye worm)	thioredoxin reductase	0.0085	0.1694	0.4075
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0022	0.0266	0.009
Mycobacterium tuberculosis	Probable dehydrogenase	0.0193	0.4148	0.8837

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15.2 uM	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins	ChEMBL.	19889536

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL568845

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1069020