Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0198 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.0303 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0303 | 0.1195 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0198 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1714 | 1 |
Onchocerca volvulus | 0.004 | 0.0303 | 0.045 | |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.004 | 0.0303 | 0.045 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1714 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0198 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0303 | 0.1195 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0198 | 0.1153 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0198 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0198 | 0.5 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0087 | 0.2532 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.078 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.0303 | 0.045 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.0303 | 0.045 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0198 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.2532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.078 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 0.2532 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0198 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.1714 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.078 |
Onchocerca volvulus | 0.0087 | 0.2532 | 1 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0198 | 0.1153 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0198 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0309 | 0.1803 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0198 | 0.078 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1714 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0198 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0309 | 0.1803 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.1714 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0198 | 0.078 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.1714 | 0.6494 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1714 | 0.6768 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0198 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.078 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0198 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0198 | 0.078 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1714 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0198 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.0303 | 0.045 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0198 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0303 | 0.045 | |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0198 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0303 | 0.1195 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1714 | 0.6494 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.0303 | 0.1766 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0198 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of NPP7 expressed in HEK293 cells assessed as para-nitrophenylphosphoryl choline hydrolysis | ChEMBL. | 20041668 | |
Activity (binding) | Inhibition of NPP6 expressed in HEK293 cells assessed as para-nitrophenylphosphoryl choline hydrolysis | ChEMBL. | 20041668 | |
Activity (binding) | = 40.9 % | Inhibition of human autotaxin isolated from MDA-MB-231 cells assessed as FS3 substrate hydrolysis at 10 uM by FRET assay | ChEMBL. | 20041668 |
IC50 (binding) | = 17.7 microM | Inhibition of human autotaxin isolated from MDA-MB-231 cells assessed as blockade of FS3 substrate hydrolysis by FRET assay | ChEMBL. | 20041668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.