Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.017 | 0.0559 | 1 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0091 | 0.0084 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0322 | 0.1479 | 0.8494 |
Mycobacterium ulcerans | proteasome PrcA | 0.1734 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0189 | 0.0675 | 0.4112 |
Brugia malayi | hypoxia-induced factor 1 | 0.0322 | 0.1479 | 0.9006 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.017 | 0.0559 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 0.0675 | 1 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1734 | 1 | 1 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.017 | 0.0559 | 0.3401 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0155 | 0.047 | 0.6966 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.017 | 0.0559 | 0.0093 |
Brugia malayi | hypothetical protein | 0.0349 | 0.1642 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 0.0675 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.0675 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 0.0675 | 0.5 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.017 | 0.0559 | 0.0559 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 0.0675 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 0.0675 | 0.1077 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.047 | 0.5998 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.017 | 0.0559 | 0.8272 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.017 | 0.0559 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.0675 | 1 |
Brugia malayi | PAS domain containing protein | 0.0104 | 0.0163 | 0.0994 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.017 | 0.0559 | 0.8272 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.017 | 0.0559 | 0.7721 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.1642 | 1 |
Leishmania major | 0.0189 | 0.0675 | 1 | |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0155 | 0.047 | 0.047 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 0.0675 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | ChEMBL. | 11140724 |
IC50 (binding) | > 10 uM | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | ChEMBL. | 11140724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.