Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.00301134 | 0.175966 | 1 |
Brugia malayi | PHD-finger family protein | 0.00301134 | 0.175966 | 0.18639 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.00110429 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.00301134 | 0.175966 | 0.190844 |
Giardia lamblia | PHD finger protein 15 | 0.00301134 | 0.175966 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.00301134 | 0.175966 | 1 |
Brugia malayi | jmjC domain containing protein | 0.00190706 | 0.0740721 | 0.0784602 |
Loa Loa (eye worm) | PHD-finger family protein | 0.00301134 | 0.175966 | 0.385377 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.00110429 | 0 | 0.5 |
Echinococcus multilocularis | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0125362 |
Echinococcus multilocularis | peregrin | 0.0119419 | 1 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.00301134 | 0.175966 | 0.110045 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.011097 | 0.922038 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00605283 | 0.456606 | 0.5 |
Echinococcus granulosus | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0125362 |
Brugia malayi | Bromodomain containing protein | 0.0113358 | 0.944072 | 1 |
Schistosoma mansoni | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0929242 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.00190706 | 0.0740721 | 0.162223 |
Schistosoma mansoni | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0929242 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.00301134 | 0.175966 | 0.110045 |
Echinococcus granulosus | peregrin | 0.0119419 | 1 | 1 |
Echinococcus granulosus | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0125362 |
Schistosoma mansoni | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0929242 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.00301134 | 0.175966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00301134 | 0.175966 | 0.385377 |
Echinococcus multilocularis | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0125362 |
Loa Loa (eye worm) | hypothetical protein | 0.00605283 | 0.456606 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.00301134 | 0.175966 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.00301134 | 0.175966 | 0.5 |
Schistosoma mansoni | enhancer of polycomb | 0.00203285 | 0.0856797 | 0.0929242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 3.1 uM | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 20014857 |
IC50 (functional) | = 186 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 assessed as [3H]hypoxanthine incorporation after 48 hrs by beta-counter | ChEMBL. | 20014857 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 20014857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.