Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0261 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0261 |
Echinococcus granulosus | geminin | 0.0173 | 0.2187 | 0.283 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0061 | 0.0551 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0261 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0168 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0196 | 0.0052 |
Echinococcus multilocularis | geminin | 0.0173 | 0.2187 | 0.283 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0403 | 0.0403 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0261 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.0261 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0261 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0261 | 0.0171 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0261 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0261 | 0.5 |
Leishmania major | modification methylase-like protein | 0.0256 | 0.3382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0403 | 0.0403 |
Echinococcus granulosus | integrin beta 2 | 0.052 | 0.7231 | 1 |
Loa Loa (eye worm) | STAT protein | 0.0162 | 0.2014 | 0.2014 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0261 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.3501 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0403 | 0.0403 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0261 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0261 | 0.5 |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0061 | 0.0551 | 0.0504 |
Onchocerca volvulus | 0.0041 | 0.0261 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0168 | 0.0168 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0261 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0261 | 0.0261 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0111 | 0.1283 | 0.1283 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0261 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0261 | 0.0261 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0061 | 0.0551 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.052 | 0.7231 | 1 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0256 | 0.3382 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0261 | 0.0092 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0261 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0261 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0261 | 0.5 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0196 | 0.0196 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0261 | 0.0261 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0261 | 0.0092 |
Brugia malayi | Kelch motif family protein | 0.0111 | 0.1283 | 0.1283 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0261 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0261 | 0.0261 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1283 | 0.1283 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0261 | 0.0171 |
Onchocerca volvulus | 0.0041 | 0.0261 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2187 | 0.3712 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0261 | 0.0261 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0196 | 0.0052 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0261 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0403 | 0.0403 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0061 | 0.0551 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0408 | 0.5607 | 1 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0162 | 0.2014 | 0.2014 |
Plasmodium falciparum | DNA (cytosine-5)-methyltransferase | 0.0061 | 0.0551 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1283 | 0.1283 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0261 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0261 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2187 | 0.3712 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0061 | 0.0551 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0261 | 0.0261 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0261 | 0.5 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0061 | 0.0551 | 1 |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0061 | 0.0551 | 0.0704 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 21 mm | Antibacterial activity against Escherichia coli ATTC 25922 after 24 hrs by disk diffusion method | ChEMBL. | 19423195 |
MIC (functional) | = 6.25 mg/ml | Antibacterial activity against Escherichia coli ATTC 25922 after 24 hrs by disk diffusion method | ChEMBL. | 19423195 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.