TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 249.202 | Formula: C12H12NO3P
H donors: 2 H acceptors: 4 LogP: 0.49 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OP(=O)(Cc1nccc(c1)c1ccccc1)O
InChi: 1S/C12H12NO3P/c14-17(15,16)9-12-8-11(6-7-13-12)10-4-2-1-3-5-10/h1-8H,9H2,(H2,14,15,16)
InChiKey: AOBQCTXYNAOHOP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0103	0.0865
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0103	0.0118
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0103	0.0865
Echinococcus granulosus	intermediate filament protein	0.0029	0.0466	0.0536
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0103	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.087	0.1001
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0103	0.0118
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.1187	0.1365
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0103	0.0865
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.05	1	0.5
Schistosoma mansoni	cpg binding protein	0.0032	0.0539	0.062
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	1
Echinococcus multilocularis	cpg binding protein	0.0032	0.0539	0.062
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0103	0.0118
Echinococcus multilocularis	dnaJ subfamily B	0.0436	0.8695	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0025	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0103	0.0118
Brugia malayi	ecdysteroid receptor	0.0011	0.0103	0.0865
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0103	0.0118
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0223	0.1877
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.087	0.1001
Brugia malayi	nuclear hormone receptor	0.0011	0.0103	0.0865
Schistosoma mansoni	jumonji domain containing protein	0.0063	0.1152	0.1325
Echinococcus multilocularis	jumonji domain containing 1A	0.0017	0.0223	0.0256
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.05	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0103	0.0118
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.08	0.0935
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.0064	0.1187	0.1365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0103	0.0865
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0103	0.0118
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0025	0.5
Brugia malayi	intermediate filament protein	0.0029	0.0466	0.3924
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0076	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0103	0.0865
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0063	0.1152	0.1325
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0103	0.0118
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0466	0.3924
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0103	0.0118
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1197	0.1377
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0165	0.019
Schistosoma mansoni	jumonji domain containing protein	0.0017	0.0223	0.0256
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0103	0.0865
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0466	0.3924
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0025	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0074	0.0623
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0466	0.3924
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.1187	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0103	0.0865
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0103	0.0118
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0466	0.0536
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.087	0.1001
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0063	0.1152	0.1325
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0103	0.0118
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0258	0.0297
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0258	0.0297
Brugia malayi	jmjC domain containing protein	0.0063	0.1152	0.9703
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0039	0.0044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0103	0.0865
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0103	0.0118
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.2964	0.4444
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0039	0.0044
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0017	0.0223	0.0256
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0103	0.0118
Echinococcus multilocularis	lysine specific demethylase 6a	0.0017	0.0223	0.0256
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0103	0.0865
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.1187	0.1365
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0103	0.0118
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.087	0.7331
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0103	0.0865
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0025	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0103	0.0865
Schistosoma mansoni	lamin	0.0029	0.0466	0.0536
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0025	0.5
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0103	0.0865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.087	0.1001
Echinococcus granulosus	lysine specific demethylase 6a	0.0017	0.0223	0.0256
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0103	0.0865
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1057	0.0853
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0103	0.0118
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.08	0.0935
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0165	0.019
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0039	0.0044
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0152	0.2964	0.4444
Echinococcus granulosus	dnaJ subfamily B	0.0436	0.8695	1
Onchocerca volvulus		0.0029	0.0466	0.9059
Brugia malayi	jmjC domain containing protein	0.0017	0.0223	0.1877
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0103	0.0118
Echinococcus multilocularis	JmjC domain containing protein 4	0.0017	0.0223	0.0256
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0504	0.4242
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0039	0.0044
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0322	0.639	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0076	0.0643
Schistosoma mansoni	protein phosphatase 2C	0.0017	0.0223	0.0256
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0025	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0103	0.0865
Schistosoma mansoni	cpg binding protein	0.0031	0.0504	0.0579
Schistosoma mansoni	coup transcription factor	0.0011	0.0103	0.0118
Trichomonas vaginalis	helicase, putative	0.0007	0.0025	0.5
Echinococcus granulosus	jumonji domain containing 1A	0.0017	0.0223	0.0256
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0103	0.0118
Brugia malayi	jmjC domain containing protein	0.0017	0.0223	0.1877
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.05	1	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.08	0.0935
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0223	0.1877
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0223	0.1877
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.05	1	1
Brugia malayi	jmjC domain containing protein	0.0064	0.1187	1
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0103	0.0118
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0504	0.4242
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0103	0.0865
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0025	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.087	0.1001
Echinococcus granulosus	phd:f box containing protein	0.0017	0.0223	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0155	0.1303
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0223	0.1877
Brugia malayi	jmjC domain containing protein	0.0017	0.0223	0.1877
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0455	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0223	0.1877
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.087	0.1001
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0322	0.639	1
Onchocerca volvulus		0.0031	0.0504	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0103	0.0865
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Echinococcus multilocularis	lamin	0.0029	0.0466	0.0536
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0103	0.0118
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0076	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0223	0.1877
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0103	0.0865
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0103	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0103	0.0865
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0103	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0155	0.1303
Schistosoma mansoni	cpg binding protein	0.0032	0.0539	0.062
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0103	0.0118
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0322	0.639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Echinococcus multilocularis	lamin dm0	0.0029	0.0466	0.0536
Echinococcus granulosus	lamin	0.0029	0.0466	0.0536
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0103	0.0118
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.2964	0.4444
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0025	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0103	0.0118
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0103	0.0118
Leishmania major	mitochondrial DNA polymerase beta	0.0322	0.639	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0103	0.0865
Echinococcus multilocularis	musashi	0.0029	0.0466	0.0536
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.087	0.1001
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0539	0.062
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.087	0.7331
Echinococcus multilocularis	phd:f box containing protein	0.0017	0.0223	0.0256
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0039	0.0044
Echinococcus granulosus	JmjC domain containing protein 4	0.0017	0.0223	0.0256
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.1	0.126
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0103	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0865
Brugia malayi	jmjC domain containing protein	0.0017	0.0223	0.1877
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0103	0.0118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0103	0.0865
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0103	0.0865
Echinococcus granulosus	lamin dm0	0.0029	0.0466	0.0536
Echinococcus multilocularis	lysine specific demethylase 5A	0.0063	0.1152	0.1325
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0196	0.1653
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0025	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0196	0.1653
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0103	0.0865
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0103	0.0118
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0103	0.0865
Onchocerca volvulus		0.0029	0.0466	0.9059
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.08	0.0935
Toxoplasma gondii	hypothetical protein	0.0052	0.0934	0.0728
Schistosoma mansoni	hypothetical protein	0.0436	0.8695	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0165	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0466	0.3924
Schistosoma mansoni	lamin	0.0029	0.0466	0.0536
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0103	0.0118
Brugia malayi	steroid hormone receptor	0.0011	0.0103	0.0865
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0103	0.0118
Schistosoma mansoni	phd/f-box containing protein	0.0017	0.0223	0.0256
Schistosoma mansoni	phosphatidylserine receptor	0.0017	0.0223	0.0256
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0103	0.0118

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.9 uM	Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preincubated for 10 mins	ChEMBL.	21561155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1801648

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1081455