TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.422 | Formula: C18H25N5O5
H donors: 3 H acceptors: 4 LogP: -0.4 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)Nc1ccc(cc1)C(=O)N(CC(=O)N1CCC(CC1)OCC(=O)O)C
InChi: 1S/C18H25N5O5/c1-22(17(27)12-2-4-13(5-3-12)21-18(19)20)10-15(24)23-8-6-14(7-9-23)28-11-16(25)26/h2-5,14H,6-11H2,1H3,(H,25,26)(H4,19,20,21)
InChiKey: ZHAKUWZVKLGILC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	CYP4Cod1	0.004	0.0202	0.0183
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0569	0.2616
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0063	0.0569	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2708	0.2694
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0163	0.2176	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0178	0.2418	0.4956
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.117
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	1
Brugia malayi	Cytochrome P450 family protein	0.004	0.0202	0.0062
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0569	0.1735
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0163	0.2176	1
Schistosoma mansoni	semaphorin 5-related	0.0082	0.0878	0.1605
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0569	0.2616
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.018	0.2444	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0115	0.1399	0.5097
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0063	0.0569	0.0552
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0569	0.2616
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0163	0.2176	0.824
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.117
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.1735
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0063	0.0569	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.1735
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0064	0.0595	0.0972
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0163	0.2176	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0145	0.1879	0.8637
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.1735
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0569	0.2616
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Entamoeba histolytica	protein kinase domain containing protein	0.0046	0.0295	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.019	0.261	1
Brugia malayi	Sema domain containing protein	0.0082	0.0878	0.0748
Mycobacterium leprae	conserved hypothetical protein	0.0052	0.0396	0.5
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0266	0.3818	0.8
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0145	0.1879	0.8637
Mycobacterium ulcerans	putative regulatory protein	0.0052	0.0396	0.3085
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0063	0.0569	0.0932
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0111	0.1345	0.4878
Loa Loa (eye worm)	hypothetical protein	0.0203	0.2814	0.28
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0323	0.4737	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.2616
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.1172	0.4176
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0569	0.1735
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0878	0.0861
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0878	0.0861
Leishmania major	hypothetical protein, conserved	0.0063	0.0569	0.2616
Entamoeba histolytica	tyrosin kinase, putative	0.0046	0.0295	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0063	0.0569	0.0932
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0063	0.0569	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0141	0.0122
Loa Loa (eye worm)	sema domain-containing protein	0.0082	0.0878	0.0861
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.009	0.1004	0.3495
Echinococcus multilocularis	plexin a4	0.0232	0.3283	0.6837
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Mycobacterium ulcerans	putative regulatory protein	0.0052	0.0396	0.3085
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.1172	0.4176
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0176	0.2382	0.2273
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0115	0.1399	0.5097
Plasmodium falciparum	phosphodiesterase delta, putative	0.0063	0.0569	1
Echinococcus granulosus	semaphorin 1A	0.0082	0.0878	0.1605
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0202	0.0183
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0202	0.0928
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0063	0.0569	0.2616
Brugia malayi	hypothetical protein	0.0082	0.0878	0.0748
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Onchocerca volvulus		0.0196	0.2708	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0176	0.2382	0.4876
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0163	0.2176	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0145	0.1879	0.3782
Brugia malayi	Plexin repeat family protein	0.0196	0.2708	0.2604
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0063	0.0569	0.1735
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0569	0.0552
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.261	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.009	0.1004	0.3495
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.1172	0.4176
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0145	0.1879	0.8637
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0063	0.0569	0.0932
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0178	0.2418	0.4956
Brugia malayi	hypothetical protein	0.0082	0.0878	0.0748
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0111	0.1345	0.4878
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0063	0.0569	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0569	0.2616
Schistosoma mansoni	plexin	0.0196	0.2708	0.5585
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0141	0.0122
Schistosoma mansoni	hypothetical protein	0.0082	0.0878	0.1605
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0115	0.1399	0.5097
Echinococcus granulosus	semaphorin 5B	0.0082	0.0878	0.1605
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0063	0.0569	1
Echinococcus multilocularis	semaphorin 5B	0.0082	0.0878	0.1605
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0063	0.0569	0.2616
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0063	0.0569	0.0932
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0063	0.0569	0.0435
Trypanosoma brucei	cytochrome P450, putative	0.004	0.0202	0.0928
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0145	0.1879	0.7242
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0063	0.0569	0.1735
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0063	0.0569	0.2616
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0145	0.1879	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Loa Loa (eye worm)	hypothetical protein	0.0589	0.8996	0.8994
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0145	0.1879	0.8637
Schistosoma mansoni	plexin	0.0114	0.1395	0.2728
Toxoplasma gondii	hypothetical protein	0.01	0.1172	0.379
Loa Loa (eye worm)	PDE1B protein	0.0323	0.4737	0.4727
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0063	0.0569	0.0932
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0063	0.0569	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0878	0.0861
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0266	0.3818	0.3729
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0163	0.2176	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0323	0.4737	0.4662
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0878	0.0861
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	1
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0063	0.0569	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1984	0.1969
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0111	0.1345	0.6184
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0878	0.0861
Brugia malayi	plexin A	0.0232	0.3283	0.3187
Trypanosoma brucei	hypothetical protein, conserved	0.0063	0.0569	0.2616
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0202	0.0928
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0163	0.2176	0.4427
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Brugia malayi	Sema domain containing protein	0.0082	0.0878	0.0748
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Loa Loa (eye worm)	plexin A	0.0232	0.3283	0.327
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0141	0.0122
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0116	0.1415	0.2772
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0178	0.2418	0.4956
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.019	0.261	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0063	0.0569	0.0932
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0063	0.0569	0.1735
Schistosoma mansoni	hypothetical protein	0.0114	0.1395	0.2728
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0063	0.0569	0.0932
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0323	0.4737	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.1735
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2382	0.2367
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Echinococcus multilocularis	hypothetical protein	0.0082	0.0878	0.1605
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0178	0.2418	0.4956
Leishmania major	hypothetical protein, conserved	0.0063	0.0569	0.2616
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0569	0.2616
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0116	0.1415	0.1399
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0052	0.0396	0.4766
Plasmodium vivax	phosphodiesterase gamma, putative	0.0063	0.0569	0.117
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0063	0.0569	0.2616
Echinococcus granulosus	plexin a4	0.0232	0.3283	0.6837
Schistosoma mansoni	hypothetical protein	0.0082	0.0878	0.1605
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0163	0.2176	0.824
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0396	0.1032
Loa Loa (eye worm)	sema domain-containing protein	0.0082	0.0878	0.0861
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0063	0.0569	0.1735
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.019	0.261	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0063	0.0569	0.0932
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0266	0.3818	0.8
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0178	0.2418	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0141	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0878	0.0861
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0063	0.0569	0.2616
Brugia malayi	Cytochrome P450 family protein	0.004	0.0202	0.0062
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0323	0.4737	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0163	0.2176	0.4427
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0163	0.2176	0.4427
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0063	0.0569	0.0847
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0163	0.2176	0.824
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0079	0.083	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0116	0.1415	0.1292
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0202	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0652	1	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0145	0.1879	0.3782
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0145	0.1879	0.7242
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0079	0.083	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0178	0.2418	0.4956
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1395	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2418	0.2404
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0163	0.2176	0.824
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0116	0.1415	0.2772
Leishmania major	cytochrome p450-like protein	0.004	0.0202	0.0928

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	0 uM	Tested in vitro for collagen induced platelet aggregation inhibitory activity using human platelet rich plasma (PRP) anti-coagulated with 0.38% trisodium citrate; No data	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 109142