Detailed information for compound 1098285

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 252.227 | Formula: C10H12N4O4
  • H donors: 3 H acceptors: 6 LogP: -1.43 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1ncc2c1ncnc2
  • InChi: 1S/C10H12N4O4/c15-3-6-7(16)8(17)10(18-6)14-9-5(2-13-14)1-11-4-12-9/h1-2,4,6-8,10,15-17H,3H2/t6-,7-,8-,10?/m1/s1
  • InChiKey: FZGIESUOSIXWOH-JSDYZDKHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.014 0.0137
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0093 0.014
Brugia malayi Matrixin family protein 0.2712 0.2738 0.4121
Brugia malayi Hemopexin family protein 0.3845 0.389 0.5854
Echinococcus multilocularis expressed conserved protein 0.0101 0.0086 0.0084
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0034 0.0032
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.002 0.0026
Echinococcus multilocularis pyruvate kinase 0.0036 0.002 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0033 0.3253
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0732 0.0727 0.1095
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0034 0.0051
Brugia malayi Matrixin family protein 0.2712 0.2738 0.4121
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0005 0.0006
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.002 0.6208
Brugia malayi Importin beta-1 subunit 0.0028 0.0012 0.0018
Loa Loa (eye worm) carbonic anhydrase 3 0.0732 0.0727 0.1089
Brugia malayi hypothetical protein 0.0025 0.0009 0.0014
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0005 0.0002
Plasmodium falciparum pyruvate kinase 0.0036 0.002 0.0545
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0033 0.3253
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0007
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.002 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0033 0.0038
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.002 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0066
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0023 0.0021
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0012 0.0283
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0006 0.0816
Loa Loa (eye worm) hypothetical protein 0.2712 0.2738 0.4117
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.002 0.0545
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0344 0.0333 0.0501
Schistosoma mansoni hypothetical protein 0.0044 0.0029 0.0067
Brugia malayi RNA, U transporter 1 0.0079 0.0064 0.0096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0004 0.1032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0201
Plasmodium vivax importin-beta 2, putative 0.0028 0.0012 0.5173
Echinococcus granulosus snurportin 1 0.0298 0.0286 0.0284
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0046 0.003 0.0039
Schistosoma mansoni polycystin 1-related 0.0524 0.0516 0.1321
Loa Loa (eye worm) hypothetical protein 0.0313 0.0301 0.0447
Echinococcus multilocularis GPCR, family 2 0.005 0.0034 0.0032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0005 0.0006
Schistosoma mansoni pyruvate kinase 0.0036 0.002 0.0046
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0009 0.056
Loa Loa (eye worm) pyruvate kinase 0.0036 0.002 0.0024
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0005 0.0007
Schistosoma mansoni lamin 0.0026 0.001 0.0019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0033 0.0038
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.003 0.0028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0886 0.0883 0.0881
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0005 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0002
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0108 0.0093 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0009
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0344 0.0333 0.0501
Schistosoma mansoni hypothetical protein 0.3845 0.389 1
Plasmodium falciparum importin beta, putative 0.0028 0.0012 0.0283
Toxoplasma gondii hypothetical protein 0.0344 0.0333 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0033 0.005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0033 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0036 0.002 0.0024
Loa Loa (eye worm) pyruvate kinase 0.0036 0.002 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0143 0.0215
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.9859 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.0023 0.2156
Onchocerca volvulus 0.0026 0.001 0.0009
Schistosoma mansoni carbonic anhydrase 0.0344 0.0333 0.085
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0004 0.0002
Echinococcus multilocularis pyruvate kinase 0.0036 0.002 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.001 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.003 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0028 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.2712 0.2738 0.4117
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0033 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0034 0.0032
Leishmania major importin beta-1 subunit, putative 0.0023 0.0006 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0033 0.0043
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0005 0.0006
Echinococcus granulosus muscleblind protein 0.0313 0.0301 0.0299
Loa Loa (eye worm) intermediate filament protein 0.0026 0.001 0.0009
Echinococcus granulosus carbonic anhydrase 0.0344 0.0333 0.0331
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.3302 0.3339 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0732 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0093 0.0133
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0033 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0028 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0093 0.0139
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0033 0.0038
Echinococcus multilocularis muscleblind protein 1 0.0313 0.0301 0.0299
Echinococcus multilocularis protein dispatched 1 0.0053 0.0037 0.0035
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0021 1
Plasmodium vivax pyruvate kinase, putative 0.0036 0.002 0.9968
Schistosoma mansoni lamin 0.0026 0.001 0.0019
Schistosoma mansoni hypothetical protein 0.0107 0.0093 0.0232
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0005 0.0006
Onchocerca volvulus 0.0026 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0057 0.0041 0.0055
Echinococcus multilocularis pyruvate kinase 0.0029 0.0013 0.001
Loa Loa (eye worm) matrixin family protein 0.6556 0.6645 1
Echinococcus multilocularis carbonic anhydrase II 0.0732 0.0727 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0007
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0344 0.0333 0.0501
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0005 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0002
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0732 0.0727 1
Echinococcus granulosus carbonic anhydrase 0.0344 0.0333 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0005 0.0007
Echinococcus multilocularis lamin dm0 0.0026 0.001 0.0008
Echinococcus granulosus Protein patched homolog 1 0.0046 0.003 0.0028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0005 0.0006
Mycobacterium ulcerans hydrolase 0.3302 0.3339 1
Echinococcus granulosus carbonic anhydrase 0.0344 0.0333 0.0331
Brugia malayi nuclear hormone receptor 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.005 0.0034 0.0045
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.2712 0.2738 0.7038
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0034 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0033 0.0398
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0344 0.0333 0.0495
Schistosoma mansoni hypothetical protein 0.0344 0.0333 0.085
Trypanosoma brucei pyruvate kinase 1 0.0036 0.002 0.0223
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0005 0.0002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0344 0.0333 0.0501
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0039 0.0023 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0033 0.005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0033 0.0038
Echinococcus granulosus GPCR family 2 0.005 0.0034 0.0032
Echinococcus granulosus pyruvate kinase 0.0036 0.002 0.0018
Schistosoma mansoni pyruvate kinase 0.0036 0.002 0.0046
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.0286 0.0424
Brugia malayi Matrixin family protein 0.6556 0.6645 1
Schistosoma mansoni carbonic anhydrase-related 0.0344 0.0333 0.085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0298 0.0286 0.073
Brugia malayi steroid hormone receptor 0.0021 0.0005 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.001 0.0009
Mycobacterium leprae PROBABLE HYDROLASE 0.3302 0.3339 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.002 0.0031
Schistosoma mansoni intermediate filament proteins 0.0026 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0005 0.0006
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.5962 0.6041 0.5
Echinococcus granulosus lamin dm0 0.0026 0.001 0.0008
Echinococcus granulosus expressed conserved protein 0.0101 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0344 0.0333 0.0495
Loa Loa (eye worm) hypothetical protein 0.0344 0.0333 0.0495
Schistosoma mansoni hypothetical protein 0.0044 0.0029 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0007
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0732 0.0727 0.1865
Brugia malayi CHE-14 protein 0.0046 0.003 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0344 0.0333 0.0331
Entamoeba histolytica hypothetical protein 0.0039 0.0023 0.2156
Echinococcus granulosus importin subunit beta 1 0.0028 0.0012 0.0009
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0093 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0028 0.0067
Schistosoma mansoni hypothetical protein 0.0044 0.0029 0.0067
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0004 0.0002
Echinococcus multilocularis lamin 0.0026 0.001 0.0008
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0313 0.0301 0.0447
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0012 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0028 0.0026
Brugia malayi Matrixin family protein 0.2712 0.2738 0.4121
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0006 0.0029
Schistosoma mansoni importin beta-1 0.0028 0.0012 0.0024
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.014 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.003 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0028 0.0026
Echinococcus multilocularis muscleblind protein 0.0313 0.0301 0.0299
Schistosoma mansoni ran 0.0021 0.0004 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.2712 0.2738 0.4117
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.222 0.2239 0.5754
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0002
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0066
Echinococcus multilocularis snurportin 1 0.0298 0.0286 0.0284
Onchocerca volvulus 0.2712 0.2738 0.449
Schistosoma mansoni patched 1 0.0046 0.003 0.0072
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0011
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0012 0.0009
Schistosoma mansoni ran 0.0021 0.0004 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0034 0.0032
Onchocerca volvulus Matrilysin homolog 0.2712 0.2738 0.449
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0034 0.0032
Brugia malayi Muscleblind-like protein 0.0313 0.0301 0.0453
Brugia malayi Matrixin family protein 0.2712 0.2738 0.4121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.005 0.0034 0.0081
Plasmodium falciparum carbonic anhydrase 0.0344 0.0333 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0006 0.0816
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0005 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0005 0.0006
Leishmania major carbonic anhydrase-like protein 0.0732 0.0727 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0007
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.002 0.6208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0028 0.0067
Onchocerca volvulus Matrix metalloproteinase homolog 0.6014 0.6094 1
Echinococcus multilocularis musashi 0.0026 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0007
Loa Loa (eye worm) matrixin family protein 0.6014 0.6094 0.917
Echinococcus granulosus lamin 0.0026 0.001 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0033 0.0038
Onchocerca volvulus 0.3845 0.389 0.638
Mycobacterium ulcerans hypothetical protein 0.0049 0.0033 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0005 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0028 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0033 0.0038
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0344 0.0333 0.0501
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0732 0.0727 0.1865
Echinococcus multilocularis carbonic anhydrase 0.0344 0.0333 0.0331
Schistosoma mansoni hypothetical protein 0.005 0.0034 0.0081
Schistosoma mansoni carbonic anhydrase-related 0.0344 0.0333 0.085
Echinococcus multilocularis protein patched 0.0046 0.003 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0023 0.0021
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0732 0.0727 0.1095
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.002 0.0006
Leishmania major pyruvate kinase 0.0036 0.002 0.0223
Schistosoma mansoni coup transcription factor 0.0021 0.0005 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0028 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0028 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0033 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.0024
Schistosoma mansoni hypothetical protein 0.005 0.0034 0.0081
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0021 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0033 0.0398
Brugia malayi ecdysteroid receptor 0.0021 0.0005 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0007
Onchocerca volvulus Matrilysin homolog 0.6014 0.6094 1
Brugia malayi MH2 domain containing protein 0.0119 0.0105 0.0158
Leishmania major pyruvate kinase 0.0036 0.002 0.0223
Entamoeba histolytica hypothetical protein 0.0039 0.0023 0.2156
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0023 0.0054
Echinococcus granulosus intermediate filament protein 0.0026 0.001 0.0008
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0732 0.0727 0.1089
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.3302 0.3339 0.5025
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0004 0.0056
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.003 0.0028
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0009 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0012 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0009 0.3669
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0021 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0005 0.0002
Entamoeba histolytica hypothetical protein 0.0039 0.0023 0.2156
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.002 0.0223
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0105 0.0151
Giardia lamblia Pyruvate kinase 0.0036 0.002 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0006 0.0816
Echinococcus granulosus pyruvate kinase 0.0036 0.002 0.0018
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.1035
Brugia malayi hypothetical protein 0.0039 0.0023 0.0035
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0021 0.0547
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0201
Brugia malayi Latrophilin receptor protein 2 0.005 0.0034 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0005 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0033 0.3253
Loa Loa (eye worm) hypothetical protein 0.0049 0.0033 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0007
Brugia malayi intermediate filament protein 0.0026 0.001 0.0015
Onchocerca volvulus 0.0049 0.0033 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0143 0.0215
Schistosoma mansoni hypothetical protein 0.005 0.0034 0.0081
Echinococcus granulosus carbonic anhydrase II 0.0732 0.0727 0.0725
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0033 0.0044
Loa Loa (eye worm) matrix metalloproteinase 0.2712 0.2738 0.4117
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0105 0.0151
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0033 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.3302 0.3339 0.5022
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0732 0.0727 1
Schistosoma mansoni carbonic anhydrase-related 0.0344 0.0333 0.085
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0157 0.0143 0.0209
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0143 0.0209
Loa Loa (eye worm) hypothetical protein 0.0344 0.0333 0.0495
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0002
Brugia malayi nuclear receptor NHR-88 0.0021 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0033 0.0043
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.002 0.0223
Schistosoma mansoni hypothetical protein 0.0044 0.0029 0.0067
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0093 0.009
Entamoeba histolytica hypothetical protein 0.0023 0.0006 0.024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0009 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0005 0.0006
Echinococcus multilocularis carbonic anhydrase 0.0344 0.0333 0.0331
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0094 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0033 0.005

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) > 0.0001 M In vitro inhibition of growth of L1210 mouse leukemic cells ChEMBL. 7328577

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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