Detailed information for compound 110324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.465 | Formula: C24H27FO8
  • H donors: 1 H acceptors: 1 LogP: 2.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCCOC1OC[C@H]2[C@H]1[C@H](c1cc(OC)c(c(c1)OC)OC)c1c([C@@H]2O)cc2c(c1)OCO2
  • InChi: 1S/C24H27FO8/c1-27-18-6-12(7-19(28-2)23(18)29-3)20-13-8-16-17(33-11-32-16)9-14(13)22(26)15-10-31-24(21(15)20)30-5-4-25/h6-9,15,20-22,24,26H,4-5,10-11H2,1-3H3/t15-,20+,21-,22-,24?/m0/s1
  • InChiKey: XMVDTHJMVFZHLM-CABGXZKPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0169 0.0703 0.3848
Echinococcus granulosus caspase 0.0479 0.2629 0.2615
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0161 0.0656 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Loa Loa (eye worm) carboxylesterase 0.0282 0.1404 0.1387
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1667 1 1
Echinococcus granulosus caspase 8 0.0181 0.0781 0.0763
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0138 0.0513 0.0513
Trypanosoma cruzi metacaspase, putative 0.0181 0.0781 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0161 0.0656 0.8366
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Loa Loa (eye worm) carboxylesterase 0.1667 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0197 0.2328
Echinococcus granulosus single minded 2 0.0147 0.0571 0.0553
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0282 0.1404 0.1387
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0183 0.0794 0.0777
Echinococcus multilocularis ubiquitin specific protease 41 0.0161 0.0656 0.0638
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.0782 0.0764
Echinococcus granulosus neuroligin 0.0282 0.1404 0.1387
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0138 0.0513 0.6482
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0107 0.0322 0.0322
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0107 0.0322 0.3903
Loa Loa (eye worm) hypothetical protein 0.0669 0.3805 0.3793
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0087 0.0197 0.0873
Echinococcus multilocularis transfer RNA-Lys 0.0147 0.0571 0.0553
Mycobacterium tuberculosis Carboxylesterase LipT 0.0282 0.1404 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0282 0.1404 0.1404
Trypanosoma cruzi metacaspase, putative 0.0181 0.0781 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Onchocerca volvulus 0.0282 0.1404 0.768
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.0782 0.5296
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Plasmodium vivax hypothetical protein, conserved 0.0181 0.0781 0.5
Brugia malayi hypothetical protein 0.0282 0.1404 0.1404
Schistosoma mansoni caspase-7 (C14 family) 0.0479 0.2629 0.2629
Brugia malayi Carboxylesterase family protein 0.1667 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.0782 0.5296
Brugia malayi Cell death protein 3 precursor 0.035 0.1828 0.1828
Echinococcus granulosus aminopeptidase N 0.0107 0.0322 0.0303
Echinococcus granulosus acetylcholinesterase 0.1667 1 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0161 0.0656 1
Echinococcus granulosus caspase 2 0.035 0.1828 0.1812
Trypanosoma cruzi metacaspase, putative 0.0181 0.0781 1
Mycobacterium ulcerans putative regulatory protein 0.0147 0.0571 0.3706
Echinococcus multilocularis caspase 8 0.0181 0.0781 0.0763
Trypanosoma brucei metacaspase 0.0181 0.0781 1
Schistosoma mansoni acetylcholinesterase 0.0282 0.1404 0.1404
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.1404 0.1404
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0794 0.5392
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.1404 0.1404
Brugia malayi hypoxia-induced factor 1 0.0617 0.3483 0.3483
Toxoplasma gondii aldehyde dehydrogenase 0.0183 0.0794 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0114 0.0362 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0781 0.5498
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.1342 0.1325
Plasmodium vivax metacaspase 1, putative 0.0181 0.0781 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0183 0.0794 0.0205
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0479 0.2629 0.2615
Schistosoma mansoni caspase-7 (C14 family) 0.035 0.1828 0.1828
Echinococcus multilocularis apoptotic protease activating factor 1 0.0169 0.0703 0.0685
Trypanosoma brucei metacaspase 5, putative 0.0181 0.0781 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0161 0.0656 0.8217
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0081 0.0062
Loa Loa (eye worm) hypoxia-induced factor 1 0.0617 0.3483 0.3471
Onchocerca volvulus 0.0107 0.0322 0.1761
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0161 0.0656 0.46
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.01 0.0279 0.026
Onchocerca volvulus 0.0282 0.1404 0.768
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0161 0.0656 0.0656
Echinococcus multilocularis carboxylesterase 5A 0.1667 1 1
Onchocerca volvulus 0.0282 0.1404 0.768
Trypanosoma cruzi metacaspase 5, putative 0.0181 0.0781 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Echinococcus granulosus tumor protein p63 0.0329 0.1698 0.1682
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0656 0.46
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0197 0.2328
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0781 0.5498
Brugia malayi PAS domain containing protein 0.0199 0.0893 0.0893
Brugia malayi bHLH-PAS transcription factor 0.0147 0.0571 0.0571
Loa Loa (eye worm) acetylcholinesterase 1 0.1667 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0781 0.5498
Brugia malayi Carboxylesterase family protein 0.0282 0.1404 0.1404
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0138 0.0513 0.3564
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0479 0.2629 0.2615
Mycobacterium ulcerans aminopeptidase N PepN 0.0138 0.0513 0.3263
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0138 0.0513 0.3564
Trichomonas vaginalis spcc417.12 protein, putative 0.0282 0.1404 1
Echinococcus multilocularis neuroligin 0.0282 0.1404 0.1387
Brugia malayi Peptidase family M1 containing protein 0.0107 0.0322 0.0322
Echinococcus multilocularis para nitrobenzyl esterase 0.0282 0.1404 0.1387
Echinococcus multilocularis aminopeptidase N 0.0107 0.0322 0.0303
Brugia malayi Cytochrome P450 family protein 0.0087 0.0197 0.0197
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0282 0.1404 1
Trypanosoma brucei Metacaspase-4 0.0181 0.0781 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0181 0.0782 0.0782
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0161 0.0656 0.46
Leishmania major cytochrome p450-like protein 0.0087 0.0197 0.2287
Echinococcus granulosus caspase 3 0.0298 0.1505 0.1488
Loa Loa (eye worm) hypothetical protein 0.1667 1 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0282 0.1404 0.1387
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0161 0.0656 0.8366
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0197 0.0178
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.007 0.0088 0.0899
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0161 0.0656 0.0638
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0181 0.0781 0.9822
Trypanosoma brucei cytochrome P450, putative 0.0087 0.0197 0.2328
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0161 0.0656 0.8366
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0181 0.0781 0.9822
Trypanosoma brucei Aminopeptidase M1, putative 0.0107 0.0322 0.3974
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0794 0.5392
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0181 0.0781 0.9822
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0138 0.0513 0.0494
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Schistosoma mansoni neuroligin 3 (S09 family) 0.0282 0.1404 0.1404
Echinococcus multilocularis caspase 0.0479 0.2629 0.2615
Loa Loa (eye worm) hypothetical protein 0.1667 1 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Brugia malayi Peptidase family M1 containing protein 0.0138 0.0513 0.0513
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.007 0.0088 0.0088
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0282 0.1404 1
Echinococcus multilocularis caspase 2 0.035 0.1828 0.1812
Loa Loa (eye worm) hypothetical protein 0.007 0.0088 0.0069
Schistosoma mansoni gliotactin 0.0282 0.1404 0.1404
Loa Loa (eye worm) hypothetical protein 0.0181 0.0781 0.0763
Brugia malayi hypothetical protein 0.0272 0.1342 0.1342
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0183 0.0794 1
Brugia malayi Carboxylesterase family protein 0.0282 0.1404 0.1404
Leishmania major metacaspase, putative 0.0181 0.0781 0.9822
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0181 0.0782 0.0782
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Mycobacterium ulcerans carboxylesterase, LipT 0.0282 0.1404 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1056 0.1038
Onchocerca volvulus 0.0282 0.1404 0.768
Brugia malayi hypothetical protein 0.0669 0.3805 0.3805
Schistosoma mansoni aryl hydrocarbon receptor 0.0199 0.0893 0.0893
Trypanosoma brucei Aminopeptidase M1, putative 0.0107 0.0322 0.3974
Brugia malayi hypothetical protein 0.0107 0.0322 0.0322
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0197 0.0178
Onchocerca volvulus 0.0147 0.0571 0.3126
Loa Loa (eye worm) carboxylesterase 0.0282 0.1404 0.1387
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0181 0.0782 0.9835
Onchocerca volvulus 0.0282 0.1404 0.768
Echinococcus multilocularis tumor protein p63 0.0329 0.1698 0.1682
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0138 0.0513 0.6482
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Trypanosoma cruzi Aminopeptidase M1, putative 0.0107 0.0322 0.3974
Echinococcus granulosus ubiquitin specific protease 41 0.0161 0.0656 0.0638
Trypanosoma brucei metacaspase MCA3 0.0181 0.0781 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0161 0.0656 0.0638
Schistosoma mansoni lipoxygenase 0.0115 0.0369 0.0369
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.0782 0.0764
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.1342 0.1325
Echinococcus granulosus BC026374 protein S09 family 0.0282 0.1404 0.1387
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0161 0.0656 0.0656
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0161 0.0656 0.0656
Echinococcus multilocularis acetylcholinesterase 0.1667 1 1
Schistosoma mansoni hypothetical protein 0.0169 0.0703 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0781 0.5498
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0282 0.1404 0.1387
Loa Loa (eye worm) hypothetical protein 0.0169 0.0703 0.0685
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Schistosoma mansoni caspase-3 (C14 family) 0.0479 0.2629 0.2629
Onchocerca volvulus 0.0107 0.0322 0.1761
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0138 0.0513 0.6366
Echinococcus granulosus apoptotic protease activating factor 1 0.0169 0.0703 0.0685
Brugia malayi Carboxylesterase family protein 0.0282 0.1404 0.1404
Schistosoma mansoni lipoxygenase 0.008 0.0154 0.0154
Plasmodium falciparum metacaspase 1 0.0181 0.0781 0.5
Brugia malayi Carboxylesterase family protein 0.0282 0.1404 0.1404
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0181 0.0781 0.0781
Loa Loa (eye worm) CYP4Cod1 0.0087 0.0197 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0781 0.5498
Loa Loa (eye worm) hypothetical protein 0.0282 0.1404 0.1387
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0019 0.0019
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0161 0.0656 0.0638
Loa Loa (eye worm) aminopeptidase N 0.0138 0.0513 0.0494
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0369 0.035
Brugia malayi hypothetical protein 0.0169 0.0703 0.0703
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0794 0.0794
Echinococcus multilocularis caspase 3 0.0298 0.1505 0.1488
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0169 0.0706 0.0688
Schistosoma mansoni single-minded 0.0199 0.0893 0.0893
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0183 0.0794 0.0777
Loa Loa (eye worm) hypothetical protein 0.035 0.1828 0.1812
Echinococcus granulosus carboxylesterase 5A 0.1667 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0081 0.0062
Brugia malayi Cytochrome P450 family protein 0.0114 0.0362 0.0362
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1056 0.1056
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0138 0.0513 0.0494
Brugia malayi Cytochrome P450 family protein 0.0087 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.007 0.0088 0.0069
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0282 0.1404 1
Echinococcus multilocularis acetylcholinesterase 0.1667 1 1
Echinococcus granulosus acetylcholinesterase 0.1667 1 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.1342 0.1325
Onchocerca volvulus Cell death protein 3 homolog 0.035 0.1828 1
Trypanosoma cruzi metacaspase, putative 0.0181 0.0781 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0088 0.0069
Echinococcus granulosus para nitrobenzyl esterase 0.0282 0.1404 0.1387
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0181 0.0781 0.5498
Trypanosoma cruzi metacaspase 5, putative 0.0181 0.0781 1
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0794 0.0794
Plasmodium falciparum metacaspase-like protein 0.0181 0.0781 0.5
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0161 0.0656 0.0638
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0794 0.5392
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0369 0.035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.1404 0.1404
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0181 0.0781 0.0781
Brugia malayi MAP kinase sur-1 0.0059 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0781 0.5498
Trypanosoma brucei metacaspase MCA2 0.0181 0.0781 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.0656 0.0638
Trypanosoma cruzi aminopeptidase, putative 0.0138 0.0513 0.6482

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 50 uM In vitro cytotoxic activity of the compound was tested against ADR resistant breast cancer (MCF-7-ADR) cell line. ChEMBL. 10465531
GI50 (functional) = 50 uM In vitro cytotoxic activity of the compound was tested against ADR resistant breast cancer (MCF-7-ADR) cell line. ChEMBL. 10465531
GI50 (functional) = 60 uM In vitro cytotoxic activity of the compound was tested against melanoma (M 14) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 60 uM In vitro cytotoxic activity of the compound was tested against melanoma (M 14) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 70 uM In vitro cytotoxic activity of the compound was tested against colon (SW 620) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 70 uM In vitro cytotoxic activity of the compound was tested against colon (SW 620) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 80 uM In vitro cytotoxic activity of the compound was tested against prostate (DU-145) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 80 uM In vitro cytotoxic activity of the compound was tested against lung (H 522) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 80 uM In vitro cytotoxic activity of the compound was tested against renal (A 498) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 80 uM In vitro cytotoxic activity of the compound was tested against prostate (DU-145) cancer cell line. ChEMBL. 10465531
GI50 (functional) = 80 uM In vitro cytotoxic activity of the compound was tested against renal (A 498) cancer cell line. ChEMBL. 10465531
GI50 (functional) > 100 uM In vitro cytotoxic activity of the compound was tested against Ovarian (SK-OV3) cell line. ChEMBL. 10465531
GI50 (functional) > 100 uM In vitro cytotoxic activity of the compound was tested against Ovarian (SK-OV3) cell line. ChEMBL. 10465531

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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