Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3619 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0071 | 0.1489 | 0.0294 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0071 | 0.1489 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1489 | 0.5082 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.202 | 0.5583 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.202 | 0.5583 |
Mycobacterium ulcerans | beta-lactamase | 0.0071 | 0.1489 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0071 | 0.1489 | 0.0294 |
Leishmania major | hypothetical protein, conserved | 0.0071 | 0.1489 | 0.1519 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.1489 | 0.4114 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.1489 | 0.4114 |
Trichomonas vaginalis | esterase, putative | 0.0071 | 0.1489 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.202 | 0.5583 |
Mycobacterium leprae | Probable lipase LipE | 0.0071 | 0.1489 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.1489 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.202 | 0.5583 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0136 | 0.2929 | 1 |
Onchocerca volvulus | 0.0136 | 0.2929 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.1489 | 0.4114 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0071 | 0.1489 | 0.0294 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.1489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1489 | 0.5082 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.1489 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0136 | 0.2929 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0136 | 0.2929 | 1 |
Onchocerca volvulus | 0.0071 | 0.1489 | 0.5082 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0071 | 0.1489 | 0.0294 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.1489 | 0.5082 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.1489 | 1 |
Onchocerca volvulus | 0.0136 | 0.2929 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1489 | 0.5082 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0004 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0071 | 0.1489 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.1489 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1489 | 0.5082 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.1489 | 0.5082 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1231 | 0.3401 |
Toxoplasma gondii | ABC1 family protein | 0.0071 | 0.1489 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0071 | 0.1489 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.3619 | 1 |
Onchocerca volvulus | 0.0071 | 0.1489 | 0.5082 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.202 | 0.6897 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0136 | 0.2929 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0071 | 0.1489 | 0.0294 |
Onchocerca volvulus | 0.0071 | 0.1489 | 0.5082 | |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.1489 | 0.0294 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.1489 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.1489 | 0.5082 |
Brugia malayi | acyl-CoA desaturase | 0.0136 | 0.2929 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0136 | 0.2929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1489 | 0.5082 |
Leishmania major | stearic acid desaturase, putative | 0.0136 | 0.2929 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.1489 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.3619 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0136 | 0.2929 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0071 | 0.1489 | 0.0294 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3619 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1231 | 0.3401 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0071 | 0.1489 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1231 | 0.3401 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.1489 | 0.0294 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0.1489 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.202 | 0.6897 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0136 | 0.2929 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.1489 | 0.5082 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.202 | 0.5583 |
Brugia malayi | beta-lactamase | 0.0071 | 0.1489 | 0.5082 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1489 | 0.5082 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0136 | 0.2929 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.202 | 0.5583 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.1489 | 0.4114 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1231 | 0.3401 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.202 | 0.5583 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.1489 | 0.5082 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins | ChEMBL. | 20006498 | |
IC50 (binding) | > 10 uM | Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fraction | ChEMBL. | 20006498 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.