Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0372 | 0.104 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.018 | 0.4575 | 0.4575 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0703 | 0.1964 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0865 | 0.0865 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0595 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0372 | 0.104 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0865 | 0.0865 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.2899 | 0.2899 |
Loa Loa (eye worm) | pip kinase 2 | 0.018 | 0.4575 | 0.4575 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0372 | 0.0372 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0703 | 0.0703 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0372 | 0.104 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0865 | 0.0865 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0372 | 0.104 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0703 | 0.0703 |
Schistosoma mansoni | dihydrofolate reductase | 0.0376 | 1 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0703 | 0.0703 |
Giardia lamblia | Phosphatidylinositol-4-phosphate 5-kinase, putative | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0703 | 0.1964 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0703 | 0.0703 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0703 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0372 | 0.104 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0144 | 0.3577 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0144 | 0.3577 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.2899 | 0.2899 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0595 | 0.0595 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0595 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0144 | 0.3577 | 1 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.018 | 0.4575 | 0.4575 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0703 | 0.0703 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0144 | 0.3577 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0703 | 0.0703 |
Brugia malayi | Pip kinase protein 2 | 0.018 | 0.4575 | 0.4575 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0595 | 0.0595 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0703 | 0.1964 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0703 | 0.0703 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0703 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0703 | 0.0703 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0376 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0099 | 0.0099 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0372 | 0.104 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0703 | 0.0703 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0595 | 0.0595 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0703 | 0.1964 |
Echinococcus granulosus | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.018 | 0.4575 | 0.4575 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0703 | 0.0703 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.2899 | 0.2899 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0703 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0865 | 0.0865 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0255 | 0.6641 | 0.6387 |
Onchocerca volvulus | 0.018 | 0.4575 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0372 | 0.104 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0144 | 0.3577 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0595 | 0.0595 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0703 | 0.0703 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0372 | 0.0372 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0595 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.0703 | 0.0703 |
Giardia lamblia | Hypothetical protein | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0865 | 0.0865 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0865 | 0.0865 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0144 | 0.3577 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0376 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0372 | 0.104 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0703 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0865 | 0.0865 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0703 | 0.1964 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0703 | 0.0703 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0703 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4575 | 0.4575 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0703 | 0.0703 |
Echinococcus multilocularis | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.018 | 0.4575 | 0.4575 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0865 | 0.0865 |
Echinococcus granulosus | dihydrofolate reductase | 0.0376 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0703 | 0.1964 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0376 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0703 | 0.0703 |
Brugia malayi | Dihydrofolate reductase | 0.0376 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0595 | 0.0595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILS (functional) | > 25 % | In vivo percent increase in life span (%ILS) of mice bearing L1210 leukemia at a dose of 400 mg/kg | ChEMBL. | 7108897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.