Detailed information for compound 1111658

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.593 | Formula: C26H39NO3
  • H donors: 2 H acceptors: 3 LogP: 6.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H](CNC1=CC(=O)C(=C(C1=O)C[C@]1(C)[C@@H](C)CC[C@]2([C@H]1CCCC2=C)C)O)C
  • InChi: 1S/C26H39NO3/c1-7-16(2)15-27-20-13-21(28)24(30)19(23(20)29)14-26(6)18(4)11-12-25(5)17(3)9-8-10-22(25)26/h13,16,18,22,27,30H,3,7-12,14-15H2,1-2,4-6H3/t16-,18-,22+,25+,26+/m0/s1
  • InChiKey: OQBIQYAAYLIDNT-AZDFDGHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0055 0.0052
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0055 0.0052
Brugia malayi Fibronectin type III domain containing protein 0.0011 0.0009 0.0011
Schistosoma mansoni amine GPCR 0.0018 0.0055 0.0052
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0012 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0074
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0012 0.0017 0.0261
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Brugia malayi Protein kinase domain containing protein 0.0012 0.0017 0.0035
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0007 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Onchocerca volvulus Neuropeptide F receptor homolog 0.0018 0.0055 0.0193
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase shark 0.0012 0.0017 0.0012
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0055 0.0052
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0055 0.0052
Schistosoma mansoni nephrin 0.0013 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0005
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0007 0.0005
Schistosoma mansoni neuropeptide receptor 0.0018 0.0055 0.0052
Schistosoma mansoni hypothetical protein 0.0075 0.0388 0.0385
Loa Loa (eye worm) hypothetical protein 0.0045 0.0209 0.0628
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0265 0.0259
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0054 0.0265 0.0259
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.0164 0.0158
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0041 0.2411
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine kinase 0.0012 0.0017 0.0012
Entamoeba histolytica hypothetical protein 0.0119 0.065 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0055 0.0052
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0055 0.0049
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0145 0.0801 1
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Onchocerca volvulus 0.0012 0.0017 0.0045
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0055 0.0049
Onchocerca volvulus 0.0018 0.0055 0.0193
Loa Loa (eye worm) hypothetical protein 0.0441 0.2548 0.7825
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0055 0.0049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0055 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0127 0.0124
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0055 0.0049
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0041 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0005 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0303 0.0298
Schistosoma mansoni biogenic amine (5HT) receptor 0.1703 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0592 0.1806
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0055 0.0052
Echinococcus granulosus tyrosine protein kinase Src42A 0.0042 0.0195 0.0189
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0215 0.021
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0016 0.0013
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis pyruvate kinase 0.0018 0.005 0.0044
Echinococcus granulosus sex peptide receptor 0.0018 0.0055 0.0049
Brugia malayi Dopamine receptor protein 2 0.0018 0.0055 0.0151
Brugia malayi Pre-SET motif family protein 0.0214 0.1208 0.3701
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0209 0.0204
Echinococcus multilocularis roundabout 2 0.0017 0.0046 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Schistosoma mansoni cell adhesion molecule 0.0014 0.003 0.0027
Onchocerca volvulus Phospholipase A2 homolog 0.0441 0.2548 1
Echinococcus granulosus hypothetical protein 0.0018 0.0055 0.0049
Entamoeba histolytica hypothetical protein 0.0119 0.065 1
Onchocerca volvulus 0.0018 0.0055 0.0193
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0303 0.0301
Schistosoma mansoni hypothetical protein 0.0119 0.065 0.0648
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0075 0.0388 0.1177
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0148 0.0439
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0055 0.0049
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.0047 0.0044
Schistosoma mansoni opsin-like receptor 0.0018 0.0055 0.0052
Onchocerca volvulus 0.0018 0.0055 0.0193
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0148 0.0439
Onchocerca volvulus 0.0012 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0373
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0209 0.0628
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0055 0.0151
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.012 0.0115
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0041 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.065 0.0645
Echinococcus multilocularis pyruvate kinase 0.0018 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus defective proboscis extension response 0.0011 0.0009 0.0003
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.0164 0.0158
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.015 0.0145
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0145 0.0801 1
Schistosoma mansoni patched 1 0.0045 0.0209 0.0207
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0054 0.0265 0.0259
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.056 0.3254 0.325
Onchocerca volvulus 0.0243 0.1382 0.5416
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0054 0.0265 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0148 0.0439
Schistosoma mansoni topbp1 0.001 0.0007 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0265 0.0259
Onchocerca volvulus 0.0159 0.0883 0.3452
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0041 0.0036
Brugia malayi hypothetical protein 0.001 0.0007 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0209 0.147
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0055 0.0049
Brugia malayi Serotonin receptor 0.0018 0.0055 0.0151
Schistosoma mansoni pyruvate kinase 0.0034 0.0148 0.0146
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.005 0.301
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0087 0.025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0124
Loa Loa (eye worm) hypothetical protein 0.0055 0.0269 0.081
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1703 1 1
Brugia malayi hypothetical protein 0.0011 0.0009 0.0011
Brugia malayi Dopamine receptor protein 1 0.0018 0.0055 0.0151
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0003
Echinococcus granulosus tyrosine protein kinase ABL1 0.0012 0.0017 0.0012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0055 0.0151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.065 0.0645
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis serotonin receptor 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.056 0.3254 0.3252
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0041 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis mitogen activated protein kinase 11 0.0145 0.0801 0.0796
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.0148
Echinococcus granulosus g protein coupled receptor 0.0018 0.0055 0.0049
Schistosoma mansoni tyrosine kinase 0.0021 0.0067 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0041 0.011
Onchocerca volvulus 0.0018 0.0055 0.0193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi hypothetical protein 0.0012 0.0017 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0041 0.011
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.056 0.3254 1
Leishmania major pyruvate kinase 0.0034 0.0148 0.1407
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0018 0.0055 0.0193
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0055 0.0052
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0005
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0055 0.0052
Onchocerca volvulus 0.0018 0.0055 0.0193
Schistosoma mansoni hypothetical protein 0.0733 0.4272 0.427
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0265 0.0259
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0055 0.0049
Echinococcus granulosus twitchin 0.0014 0.0028 0.0023
Echinococcus granulosus NCK adaptor protein 0.0017 0.0047 0.0041
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0148 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0055 0.0049
Schistosoma mansoni histamine h1 receptor 0.0018 0.0055 0.0052
Echinococcus granulosus pyruvate kinase 0.0034 0.0148 0.0143
Schistosoma mansoni opsin-like receptor 0.0018 0.0055 0.0052
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0014 0.003 0.0024
Onchocerca volvulus 0.0012 0.0017 0.0045
Echinococcus multilocularis Immunoglobulin 0.0011 0.0009 0.0003
Brugia malayi SH2 domain containing protein 0.0012 0.0017 0.0035
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0148 0.1024
Echinococcus granulosus g protein coupled receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0093 0.0493 0.1502
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0148 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.056 0.8615
Brugia malayi hypothetical protein 0.0119 0.065 0.1984
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0265 0.0259
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0055 0.0151
Echinococcus granulosus c src tyrosine kinase 0.0021 0.0067 0.0061
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0042 0.0195 0.0189
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.0043 0.02 0.0197
Echinococcus granulosus pyruvate kinase 0.0018 0.005 0.0044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0127 0.0121
Leishmania major pyruvate kinase 0.0034 0.0148 0.1407
Brugia malayi SRC-1 0.0054 0.0265 0.0798
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0055 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.056 0.3254 0.325
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0303 0.0298
Brugia malayi putative neuropeptide receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi jmjC domain containing protein 0.0061 0.0303 0.0917
Onchocerca volvulus Tyrosine kinase homolog 0.0165 0.0919 0.3594
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0265 0.0259
Brugia malayi Protein kinase domain containing protein 0.0012 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.0148
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0209 0.0204
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0054 0.0265 0.0259
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0148 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0215 0.021
Schistosoma mansoni coup transcription factor 0.001 0.0005 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0148 1
Brugia malayi Protein kinase domain containing protein 0.0012 0.0017 0.0035
Echinococcus multilocularis pyruvate kinase 0.0027 0.0105 0.01
Onchocerca volvulus 0.0018 0.0055 0.0193
Onchocerca volvulus 0.0018 0.0055 0.0193
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis mitogen activated protein kinase 11 0.0145 0.0801 0.0796
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0303 0.0301
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0041 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Onchocerca volvulus 0.0012 0.0017 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0005 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0148 0.0439
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1382 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0012 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0041 0.011
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0041 0.0428
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0148 0.1775
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0055 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0005 0.0003
Schistosoma mansoni adenoreceptor 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.011
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0148 0.0561
Schistosoma mansoni amine GPCR 0.0018 0.0055 0.0052
Onchocerca volvulus 0.0018 0.0055 0.0193
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0054 0.0265 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0055 0.0049
Schistosoma mansoni neuropeptide receptor 0.0018 0.0055 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0592 0.1806
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0011
Brugia malayi P38 map kinase family protein 2 0.0145 0.0801 0.2448
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi G-protein coupled receptor 0.0018 0.0055 0.0151
Schistosoma mansoni vesicular amine transporter 0.0011 0.0009 0.0006
Echinococcus granulosus growth factor receptor bound protein 2 0.0017 0.0047 0.0041
Echinococcus granulosus neuropeptide receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0041 0.0036
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0055 0.0049
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0145 0.0801 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0007 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0055 0.0049
Brugia malayi sulfakinin receptor protein 0.0018 0.0055 0.0151
Schistosoma mansoni hypothetical protein 0.0043 0.02 0.0197
Schistosoma mansoni amine GPCR 0.0018 0.0055 0.0052
Echinococcus granulosus expressed conserved protein 0.0098 0.0523 0.0518
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.015 0.0446
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0047 0.0127
Schistosoma mansoni opsin-like receptor 0.0018 0.0055 0.0052
Echinococcus multilocularis geminin 0.0733 0.4272 0.4269
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0733 0.4272 0.427
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0055 0.0052
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni DNA ligase IV 0.001 0.0007 0.0005
Echinococcus granulosus nibrin 0.001 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0055 0.0049
Brugia malayi Protein kinase domain containing protein 0.0012 0.0017 0.0035
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0215 0.021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0055 0.0151
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0041 0.2411
Echinococcus multilocularis expressed conserved protein 0.0098 0.0523 0.0518
Schistosoma mansoni amine GPCR 0.0018 0.0055 0.0052
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0824 0.0819
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0127 0.849
Treponema pallidum DNA ligase (lig) 0.001 0.0007 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0987 0.3021
Brugia malayi CHE-14 protein 0.0045 0.0209 0.0628
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0303 0.0298
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0055 0.0049
Echinococcus granulosus mitogen activated protein kinase 11 0.0145 0.0801 0.0796
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0109 0.0592 0.1806
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0055 0.0049
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0055 0.0049
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0055 0.0049
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0857 0.5005 0.5002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus mitogen activated protein kinase 14 0.0145 0.0801 0.0796
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi Phospholipase A2 family protein 0.0093 0.0493 0.1502
Brugia malayi Protein kinase domain containing protein 0.0012 0.0017 0.0035
Echinococcus granulosus pyruvate kinase 0.0018 0.005 0.0044
Schistosoma mansoni tyrosine kinase 0.0054 0.0265 0.0262
Schistosoma mansoni tyrosine kinase 0.0012 0.0017 0.0014
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0047 0.0127
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.0047 0.0044
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0055 0.0049
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0265 0.0259
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0005
Brugia malayi AKH receptor 0.0018 0.0055 0.0151
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0055 0.0052
Echinococcus multilocularis growth factor receptor bound protein 2 0.0017 0.0047 0.0041
Schistosoma mansoni tyrosine kinase 0.0054 0.0265 0.0262
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0055 0.0049
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0047 0.0127
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus roundabout 2 0.0017 0.0046 0.004
Brugia malayi jmjC domain containing protein 0.0016 0.0041 0.011
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0148 0.1775
Brugia malayi jmjC domain containing protein 0.0016 0.0041 0.011
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0388 0.1177
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0055 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.056 0.3254 0.3252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0055 0.0052
Echinococcus granulosus geminin 0.0733 0.4272 0.4269
Echinococcus granulosus somatostatin receptor 0.0018 0.0055 0.0049
Echinococcus granulosus tyrosine protein kinase Src64B 0.0054 0.0265 0.0259
Onchocerca volvulus 0.0018 0.0055 0.0193
Echinococcus granulosus tyrosine protein kinase shark 0.0012 0.0017 0.0012
Loa Loa (eye worm) TK/ABL protein kinase 0.0012 0.0017 0.0035
Onchocerca volvulus 0.0012 0.0017 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0003
Echinococcus granulosus replication factor c subunit 1 0.001 0.0007 0.0002
Brugia malayi Pre-SET motif family protein 0.0031 0.0127 0.0373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi jmjC domain containing protein 0.0061 0.0303 0.0917
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0005 0.0003
Echinococcus multilocularis GPCR, family 2 0.0035 0.015 0.0145
Onchocerca volvulus 0.0012 0.0017 0.0045
Echinococcus granulosus allatostatin A receptor 0.0018 0.0055 0.0049
Onchocerca volvulus Phospholipase A2 homolog 0.0093 0.0493 0.192
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0148 0.1775
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0041 0.0428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0011
Brugia malayi topoisomerase 0.001 0.0007 0.0005
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0209 0.0204
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.056 0.0555
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.056 0.0555
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0021 0.0067 0.0061
Brugia malayi Serotonin receptor 0.0018 0.0055 0.0151
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.0148
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.011
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0215 0.021
Onchocerca volvulus 0.0018 0.0055 0.0193
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0148 0.0561
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0124
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0303 0.0298
Echinococcus granulosus pyruvate kinase 0.0018 0.005 0.0044
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0087 0.1336
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0176 0.0987 0.3021
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0055 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0127
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0054 0.0265 0.0259
Onchocerca volvulus 0.0018 0.0055 0.0193
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0005 0.0003
Schistosoma mansoni neuropeptide receptor 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0055 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0124
Echinococcus granulosus tyrosine protein kinase Srms 0.0012 0.0017 0.0012
Echinococcus multilocularis neuroglian 0.0013 0.0025 0.002
Echinococcus multilocularis NCK adaptor protein 0.0017 0.0047 0.0041
Brugia malayi Sex muscle abnormal protein 5 0.0017 0.0047 0.0127
Onchocerca volvulus 0.0018 0.0055 0.0193
Brugia malayi jmjC domain containing protein 0.0016 0.0041 0.011
Schistosoma mansoni topbp1 0.001 0.0007 0.0005
Brugia malayi GnHR receptor homolog 0.0018 0.0055 0.0151
Brugia malayi Dopamine receptor 0.0018 0.0055 0.0151
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0007 0.0000012614
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0087 0.025
Onchocerca volvulus 0.0031 0.0127 0.0477
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0055 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Schistosoma mansoni amine GPCR 0.0199 0.1123 0.1121
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0041 0.2411
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Echinococcus multilocularis protein dispatched 1 0.0051 0.0247 0.0241
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0127 0.0121
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0055 0.0049
Plasmodium vivax JmjC domain containing protein 0.0016 0.0041 0.2411
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Schistosoma mansoni neuropeptide receptor 0.0018 0.0055 0.0052
Brugia malayi neuropeptide F receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0446
Brugia malayi jmjC domain containing protein 0.0016 0.0041 0.011
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0215 0.021
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0055 0.0049
Brugia malayi Latrophilin receptor protein 2 0.0035 0.015 0.0446
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0041 0.0036
Onchocerca volvulus 0.0018 0.0055 0.0193
Schistosoma mansoni tyrosine kinase 0.0012 0.0017 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.015 0.0145
Schistosoma mansoni biogenic amine receptor 0.0018 0.0055 0.0052
Schistosoma mansoni tyrosine kinase 0.0021 0.0067 0.0064
Entamoeba histolytica protein kinase, putative 0.0037 0.0164 0.252
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0005 0.0003
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0148 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0055 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0592 0.1806
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0007 0.0000012614
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0012 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni biogenic amine receptor 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Plasmodium falciparum pyruvate kinase 2 0.0018 0.005 0.301
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Loa Loa (eye worm) SRC-1 0.0054 0.0265 0.0798
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0055 0.0052
Entamoeba histolytica hypothetical protein 0.0119 0.065 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0041 0.0039
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0055 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.015 0.0145
Schistosoma mansoni hypothetical protein 0.0018 0.0055 0.0052
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0041 0.0036
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0041 0.0036
Brugia malayi hypothetical protein 0.001 0.0007 0.0005
Loa Loa (eye worm) TK protein kinase 0.0046 0.0215 0.0645
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis c src tyrosine kinase 0.0021 0.0067 0.0061
Onchocerca volvulus 0.0018 0.0055 0.0193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0055 0.0049
Brugia malayi larval opioid receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Entamoeba histolytica hypothetical protein 0.001 0.0007 0.011
Schistosoma mansoni pyruvate kinase 0.0034 0.0148 0.0146
Chlamydia trachomatis pyruvate kinase 0.0034 0.0148 1
Schistosoma mansoni nck2/grb4 0.0017 0.0047 0.0044
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0055 0.0049
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0145 0.0801 0.2448
Echinococcus granulosus Immunoglobulin 0.0011 0.0009 0.0003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0127 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Brugia malayi Melatonin receptor type 1A 0.0018 0.0055 0.0151
Schistosoma mansoni hypothetical protein 0.0043 0.02 0.0197
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0011
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0007 0.011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase Abl 0.0021 0.0067 0.0061
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.0018 0.0055 0.0052
Echinococcus granulosus serotonin receptor 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.0148
Brugia malayi Tyrosine-protein kinase abl-1 0.0021 0.0067 0.0189
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0054 0.0265 0.0259
Echinococcus multilocularis mitogen activated protein kinase 14 0.0145 0.0801 0.0796
Onchocerca volvulus 0.001 0.0007 0.0007
Echinococcus granulosus pyruvate kinase 0.0034 0.0148 0.0143
Echinococcus multilocularis pyruvate kinase 0.0034 0.0148 0.0143
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0007 0.0005
Schistosoma mansoni pyruvate kinase 0.0018 0.005 0.0047
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0055 0.0052
Brugia malayi G protein-coupled receptor 0.0018 0.0055 0.0151
Echinococcus granulosus tyrosine kinase 0.0046 0.0215 0.021
Brugia malayi ORL1-like opioid receptor 0.0018 0.0055 0.0151
Onchocerca volvulus 0.0018 0.0055 0.0193
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0055 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Schistosoma mansoni adapter molecule crk 0.0017 0.0047 0.0044
Echinococcus granulosus tyrosine protein kinase Src42A 0.0054 0.0265 0.0259
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0055 0.0052
Schistosoma mansoni myosin xvIII 0.0018 0.0055 0.0052
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.057 0.0567
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0055 0.0049
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0011
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0055 0.0049
Loa Loa (eye worm) TK protein kinase 0.0037 0.0164 0.0487
Schistosoma mansoni biogenic amine receptor 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0104 0.056 0.1707
Echinococcus multilocularis mitogen activated protein kinase 14 0.0145 0.0801 0.0796
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0055 0.0049
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0017 0.0047 0.0127
Echinococcus granulosus tyrosine protein kinase Lyn 0.0055 0.0268 0.0263
Schistosoma mansoni hypothetical protein 0.0043 0.02 0.0197
Echinococcus multilocularis sex peptide receptor 0.0018 0.0055 0.0049
Brugia malayi protein-tyrosine kinase 0.0046 0.0215 0.0645
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0145 0.0801 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0009 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.015 0.0446
Brugia malayi G-protein coupled receptor 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0017 0.0047 0.0044
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0003
Echinococcus granulosus neuropeptide receptor 0.0018 0.0055 0.0049
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0055 0.0151
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0055 0.0049
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0067 0.0064
Echinococcus granulosus orexin receptor type 2 0.0018 0.0055 0.0049
Onchocerca volvulus 0.0018 0.0055 0.0193
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0055 0.0151
Brugia malayi neuropeptide F receptor 0.0018 0.0055 0.0151
Echinococcus multilocularis pyruvate kinase 0.0034 0.0148 0.0143
Echinococcus granulosus phd:f box containing protein 0.0016 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0009 0.0006
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.005 0.301
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0824 0.0819
Giardia lamblia Pyruvate kinase 0.0018 0.005 0.301
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0055 0.0049
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0009 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0055 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.015 0.0145
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0303 0.0301
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0055 0.0151
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0054 0.0265 0.0259
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0041 0.0428
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0148 0.1024
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis serotonin receptor 0.0018 0.0055 0.0049
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0055 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0303 0.0917
Echinococcus multilocularis pyruvate kinase 0.0018 0.005 0.0044
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0005
Plasmodium falciparum pyruvate kinase 0.0034 0.0148 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.056 0.1707
Giardia lamblia Pyruvate kinase 0.0034 0.0148 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi SH2 domain containing protein 0.0012 0.0017 0.0035
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0148 0.0439
Echinococcus granulosus fmrfamide receptor 0.0018 0.0055 0.0049
Entamoeba histolytica hypothetical protein 0.0119 0.065 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.0018 0.0055 0.0052
Echinococcus granulosus g protein coupled receptor 0.0018 0.0055 0.0049
Echinococcus granulosus tyrosine kinase 0.0012 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0148 0.0439
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0055 0.0151
Brugia malayi RE15519p 0.0018 0.0055 0.0151
Echinococcus granulosus GPCR family 2 0.0035 0.015 0.0145
Brugia malayi hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi indoleamine 2,3-dioxygenase 0.056 0.3254 1
Brugia malayi DKFZp564C0469 protein 0.001 0.0007 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0055 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0055 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0041 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0055 0.0049
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0055 0.0049
Schistosoma mansoni hypothetical protein 0.0018 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0009 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Echinococcus multilocularis somatostatin receptor 0.0018 0.0055 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Onchocerca volvulus 0.0018 0.0055 0.0193
Plasmodium vivax SET domain protein, putative 0.0031 0.0127 0.849
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0148 0.0561
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0017 0.0035
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0055 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0005 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.065 0.0648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0055 0.0052
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0007 0.0000012614
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1208 0.3701
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus multilocularis nibrin 0.001 0.0007 0.0002
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0148 0.1775
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0151
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0005
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0055 0.0151
Echinococcus multilocularis protein patched 0.0045 0.0209 0.0204
Echinococcus multilocularis Immunoglobulin 0.0011 0.0009 0.0003
Echinococcus granulosus neuroglian 0.0013 0.0025 0.002

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of EGFR at 1 mM ChEMBL. 20028027

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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