Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0388 | 0.1112 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Trichomonas vaginalis | heat shock protein, putative | 0.0025 | 0.0405 | 0.655 |
Echinococcus multilocularis | heat shock protein 90 | 0.0032 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0163 | 0.0468 |
Plasmodium falciparum | endoplasmin, putative | 0.002 | 0.0243 | 0.345 |
Trichomonas vaginalis | heat shock protein, putative | 0.0025 | 0.0405 | 0.655 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.3491 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0032 | 0.0585 | 0.6608 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0032 | 0.0585 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.1647 | 0.1647 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.3491 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0032 | 0.0585 | 0.1677 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.3403 | 0.9749 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0565 | 0.0565 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0013 | 0.0063 | 0.1111 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.3403 | 0.9749 |
Schistosoma mansoni | heat shock protein | 0.0013 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0101 | 0.0291 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3403 | 0.3403 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0565 | 0.1618 |
Schistosoma mansoni | endoplasmin | 0.0032 | 0.0585 | 0.0585 |
Onchocerca volvulus | 0.0031 | 0.0565 | 1 | |
Plasmodium vivax | endoplasmin, putative | 0.0032 | 0.0585 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0025 | 0.0405 | 0.1498 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0013 | 0.0063 | 0.0063 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0854 | 0.0854 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0214 | 0.2899 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0025 | 0.0405 | 0.216 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0214 | 0.5 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0032 | 0.0585 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0565 | 0.1618 |
Trichomonas vaginalis | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Schistosoma mansoni | heat shock protein | 0.0032 | 0.0585 | 0.0585 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Echinococcus multilocularis | heat shock protein | 0.0032 | 0.0585 | 0.0585 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.3403 | 0.3403 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0388 | 0.1112 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0117 | 0.0117 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0025 | 0.0405 | 0.1332 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0565 | 0.0565 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.3403 | 0.9749 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3403 | 0.3403 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0388 | 0.1214 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.1647 | 0.1647 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.1647 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0163 | 0.0468 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0388 | 0.1214 |
Schistosoma mansoni | endoplasmin | 0.0032 | 0.0585 | 0.0585 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0388 | 0.1383 |
Brugia malayi | Endoplasmin precursor | 0.0032 | 0.0585 | 0.1677 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0214 | 0.0614 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3403 | 0.3403 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0214 | 0.2899 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.3403 | 0.9749 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0214 | 0.0614 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0388 | 0.1112 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.1647 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.1647 | 0.1647 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0565 | 0.0565 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0025 | 0.0405 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Schistosoma mansoni | lamin | 0.0031 | 0.0565 | 0.0565 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0032 | 0.0585 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0025 | 0.0405 | 0.655 |
Treponema pallidum | heat shock protein 90 | 0.0025 | 0.0405 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0101 | 0.0291 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0032 | 0.0585 | 0.3299 |
Echinococcus granulosus | lamin | 0.0031 | 0.0565 | 0.0565 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.3491 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0388 | 0.1214 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0388 | 0.2055 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.1647 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0025 | 0.0405 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0019 | 0.0223 | 0.3058 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0854 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Echinococcus granulosus | endoplasmin | 0.0025 | 0.0405 | 0.0405 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0565 | 0.0565 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0117 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0388 | 0.1112 |
Brugia malayi | RNA binding protein | 0.0134 | 0.3403 | 0.9749 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0025 | 0.0405 | 0.0405 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0565 | 0.1618 |
Onchocerca volvulus | 0.0025 | 0.0388 | 0.6875 | |
Echinococcus multilocularis | heat shock protein 90 | 0.0025 | 0.0405 | 0.0405 |
Schistosoma mansoni | lamin | 0.0031 | 0.0565 | 0.0565 |
Plasmodium falciparum | heat shock protein 90 | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0214 | 0.0614 |
Echinococcus multilocularis | geminin | 0.0372 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.3403 | 0.9749 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0032 | 0.0585 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.1647 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0214 | 0.0614 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0013 | 0.0063 | 0.018 |
Onchocerca volvulus | 0.0031 | 0.0565 | 1 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0388 | 0.4116 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0388 | 0.1214 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0032 | 0.0585 | 0.6608 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0025 | 0.0405 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0388 | 0.1112 |
Echinococcus multilocularis | endoplasmin | 0.0025 | 0.0405 | 0.0405 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0854 | 0.2446 |
Trichomonas vaginalis | heat shock protein, putative | 0.002 | 0.0243 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.1647 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3403 | 0.3403 |
Brugia malayi | heat shock protein 90 | 0.0032 | 0.0585 | 0.1677 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0214 | 0.0192 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3403 | 0.3403 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0025 | 0.0405 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0388 | 0.1383 |
Trichomonas vaginalis | endoplasmin, putative | 0.002 | 0.0243 | 0.345 |
Loa Loa (eye worm) | endoplasmin | 0.0032 | 0.0585 | 0.1677 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Schistosoma mansoni | heat shock protein | 0.0032 | 0.0585 | 0.0585 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0388 | 0.1214 |
Echinococcus granulosus | heat shock protein 90 | 0.0032 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0549 | 0.1573 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0013 | 0.0063 | 0.0063 |
Echinococcus granulosus | heat shock protein 90 | 0.0025 | 0.0405 | 0.0405 |
Echinococcus granulosus | heat shock protein | 0.0032 | 0.0585 | 0.0585 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0388 | 0.2055 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0854 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0565 | 0.1618 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0388 | 0.1112 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0565 | 0.0565 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.1647 | 0.1647 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0032 | 0.0585 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.3403 | 0.3403 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0388 | 0.2055 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0565 | 0.0565 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Plasmodium vivax | heat shock protein 86, putative | 0.0032 | 0.0585 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0388 | 0.4116 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0388 | 0.1214 |
Trypanosoma brucei | heat shock protein, putative | 0.0032 | 0.0585 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0565 | 0.1618 |
Leishmania major | heat shock protein 83-1 | 0.0032 | 0.0585 | 0.3299 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0032 | 0.0585 | 0.3299 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0214 | 0.0614 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0388 | 0.1214 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0388 | 0.1214 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0854 | 0.0854 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.1647 | 1 |
Brugia malayi | Hsp90 protein | 0.0013 | 0.0063 | 0.018 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0117 | 0.0117 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0388 | 0.4116 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0032 | 0.0585 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0032 | 0.0585 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (functional) | > 50 ug ml-1 | Dose required to inhibit Murine leukemia (L1210) cell proliferation by 50% | ChEMBL. | 2540332 |
CD50 (functional) | > 50 ug ml-1 | Dose required to inhibit Human B-Lymphoblast(Raji) cell proliferation by 50% | ChEMBL. | 2540332 |
MCC (functional) | > 400 ug ml-1 | Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 400 ug ml-1 | Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 400 ug ml-1 | Minimum inhibitory concentration required to reduce polio virus -1 induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 400 ug ml-1 | Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.