TDR Targets

Basic information

Technical information

TDR Targets ID: 113350
Name: 4-[4-(4-methoxyphenyl)-2-phenyl-1H-imidazol-5 -yl]pyridine
MW: 327.379 | Formula: C21H17N3O
H donors: 1 H acceptors: 2 LogP: 3.95 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1nc([nH]c1c1ccncc1)c1ccccc1
InChi: 1S/C21H17N3O/c1-25-18-9-7-15(8-10-18)19-20(16-11-13-22-14-12-16)24-21(23-19)17-5-3-2-4-6-17/h2-14H,1H3,(H,23,24)
InChiKey: VDIYQHFWCBWRJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[5-(4-methoxyphenyl)-2-phenyl-3H-imidazol-4-yl]pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14		References
Homo sapiens	mitogen-activated protein kinase 11		References
Homo sapiens	mitogen-activated protein kinase 13	Starlite/ChEMBL	References
Homo sapiens	Raf-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase 12		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	raf kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	raf serine:threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative	Get druggable targets OG5_130459	All targets in OG5_130459
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	Raf kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	raf serine:threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 13	365 aa	366 aa	30.1 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 12	357 aa	362 aa	30.1 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 11	364 aa	361 aa	33.0 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0262	0.5619	0.5619
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0457	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Onchocerca volvulus		0.0076	0.146	1
Onchocerca volvulus	Dual oxidase homolog	0.0076	0.146	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0223	0.0223
Brugia malayi	Serotonin receptor	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.146	0.146
Onchocerca volvulus		0.0076	0.146	1
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0223	0.0223
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0223	0.0223
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0223	0.0377
Onchocerca volvulus	Peroxidase homolog	0.0076	0.146	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.146	0.146
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.5619	0.9481
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0457	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0223	0.0223
Brugia malayi	Raf kinase	0.0253	0.5414	0.5414
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0223	0.0377
Brugia malayi	neuropeptide F receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	hypothetical protein	0.0021	0.0223	0.0377
Schistosoma mansoni	opsin-like receptor	0.0021	0.0223	0.0377
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0223	0.0377
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0223	0.0223
Loa Loa (eye worm)	blistered cuticle protein 3	0.0076	0.146	0.146
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0223	0.0223
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0223	0.0377
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0457	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0223	0.0223
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0223	0.0223
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0223	0.0223
Brugia malayi	putative neuropeptide receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Onchocerca volvulus	Peroxidasin homolog	0.0076	0.146	1
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.146	0.146
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	larval opioid receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0223	0.0223
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0223	0.0377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Brugia malayi	G-protein coupled receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0223	0.0377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0223	0.0223
Brugia malayi	Blistered cuticle protein 3	0.0076	0.146	0.146
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0223	0.0223
Brugia malayi	G protein-coupled receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	opsin-like receptor	0.0021	0.0223	0.0377
Onchocerca volvulus	Peroxidasin homolog	0.0076	0.146	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	hypothetical protein	0.0021	0.0223	0.0377
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0223	0.0223
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0223	0.0223
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0223	0.0223
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	amine GPCR	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0223	0.0223
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0457	1	1
Echinococcus multilocularis	serotonin receptor	0.0021	0.0223	0.0223
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0457	1	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.146	0.146
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0223	0.0223
Echinococcus multilocularis	serotonin receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Schistosoma mansoni	amine GPCR	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Onchocerca volvulus	Peroxidase homolog	0.0076	0.146	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	myosin xvIII	0.0021	0.0223	0.0377
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0223	0.0223
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0223	0.0223
Brugia malayi	AKH receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.146	0.146
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0223	0.0223
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0223	0.0223
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0457	1	1
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0457	1	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	mitogen activated protein kinase 11	0.0457	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0223	0.0377
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0223	0.0223
Brugia malayi	G-protein coupled receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	amine GPCR	0.0021	0.0223	0.0377
Brugia malayi	Peroxidasin	0.0076	0.146	0.146
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0223	0.0377
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0223	0.0377
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.146	0.146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0223	0.0223
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0223	0.0377
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0223	0.0377
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0223	0.0223
Brugia malayi	sulfakinin receptor protein	0.0021	0.0223	0.0223
Schistosoma mansoni	amine GPCR	0.0021	0.0223	0.0377
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0223	0.0377
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	hypothetical protein	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Echinococcus granulosus	peroxidasin	0.0076	0.146	0.146
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0223	0.0223
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0457	1	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0223	0.0223
Echinococcus granulosus	sex peptide receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.146	0.146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	adenoreceptor	0.0021	0.0223	0.0377
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0148	0.3075	0.3075
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0223	0.0377
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0223	0.0223
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0223	0.0223
Brugia malayi	Dopamine receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	conserved hypothetical protein	0.0274	0.5886	0.5886
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0223	0.0223
Echinococcus granulosus	somatostatin receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0223	0.0377
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	serotonin receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Loa Loa (eye worm)	raf kinase	0.026	0.559	0.559
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0223	0.0223
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0223	0.0377
Schistosoma mansoni	peroxidasin	0.0076	0.146	0.2463
Echinococcus granulosus	mitogen activated protein kinase 14	0.0457	1	1
Brugia malayi	Serotonin receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0223	0.0223
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0223	0.0377
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.146	0.146
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0223	0.0223
Echinococcus multilocularis	conserved hypothetical protein	0.0274	0.5886	0.5886
Brugia malayi	RE15519p	0.0021	0.0223	0.0223
Schistosoma mansoni	hypothetical protein	0.0021	0.0223	0.0377
Schistosoma mansoni	amine GPCR	0.0021	0.0223	0.0377
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0457	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0223	0.0377
Brugia malayi	neuropeptide F receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Schistosoma mansoni	glucose-6-phosphatase	0.0275	0.5926	1
Schistosoma mansoni	peroxidasin	0.0076	0.146	0.2463
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0223	0.0223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0223	0.0377
Onchocerca volvulus		0.0076	0.146	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0223	0.0223
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0223	0.0223
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Onchocerca volvulus	Chorion peroxidase homolog	0.0076	0.146	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0223	0.0223
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	raf serine:threonine protein kinase	0.0262	0.5619	0.5619
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0223	0.0377
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0223	0.0377
Echinococcus granulosus	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0223	0.0223
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0223	0.0223
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.146	0.146
Schistosoma mansoni	opsin-like receptor	0.0021	0.0223	0.0377
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0223	0.0377
Echinococcus multilocularis	peroxidasin	0.0076	0.146	0.146
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0223	0.0223
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0021	0.0223	0.0223
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0076	0.146	0.146
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0223	0.0223
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0223	0.0223
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0223	0.0377
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0223	0.0223
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0223	0.0223
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0223	0.0377
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0076	0.146	0.146
Brugia malayi	GnHR receptor homolog	0.0021	0.0223	0.0223
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0223	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0223	0.0223

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 300 nM	Inhibitory activity against Mitogen-activated protein kinase p38 (MAP kinase)	ChEMBL.	10377223
IC50 (binding)	= 300 nM	Inhibitory activity against Mitogen-activated protein kinase p38 (MAP kinase)	ChEMBL.	10377223
IC50 (binding)	= 950 nM	Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase	ChEMBL.	10377223
IC50 (binding)	= 950 nM	Inhibition of Raf1 kinase (unknown origin)	ChEMBL.	18346893
IC50 (binding)	= 950 nM	Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase	ChEMBL.	10377223
IC50 (binding)	= 950 nM	Inhibition of Raf1 kinase (unknown origin)	ChEMBL.	18346893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL402426
PubChem: 10711296

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 113350