TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.729 | Formula: C16H11ClFN3O
H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1COc1ccc(nn1)c1ccccn1)Cl
InChi: 1S/C16H11ClFN3O/c17-12-4-3-5-13(18)11(12)10-22-16-8-7-15(20-21-16)14-6-1-2-9-19-14/h1-9H,10H2
InChiKey: BFRATUCMRYDWDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0106	1
Echinococcus multilocularis	carbonic anhydrase	0.034	0.2873	0.4105
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0141	0.0178
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0815	0.6974	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0815	0.6974	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0087	0.0101
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0058	0.0056
Brugia malayi	hypothetical protein	0.001	0.0022	0.0007
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0087	0.0101
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0141	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.0104
Leishmania major	carbonic anhydrase-like protein	0.0815	0.6974	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0141	0.0119
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.1152
Schistosoma mansoni	carbonic anhydrase-related	0.034	0.2873	0.4119
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0058	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.0104
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0342	0.0467
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0412	0.0567
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.028	0.0401
Echinococcus granulosus	carbonic anhydrase	0.034	0.2873	0.4105
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0106	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0412	0.0567
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0141	0.0581
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.009	0.3258
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0102	0.0122
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0141	0.0581
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0188	0.1558	0.8786
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Onchocerca volvulus	Peroxidasin homolog	0.0038	0.0267	0.1426
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0087	0.0101
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0022	0.002
Echinococcus granulosus	nibrin	0.001	0.0022	0.0007
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.1152
Leishmania major	carbonic anhydrase family protein, putative	0.0288	0.2427	0.3379
Trichomonas vaginalis	conserved hypothetical protein	0.1166	1	1
Echinococcus multilocularis	carbonic anhydrase II	0.0815	0.6974	1
Echinococcus multilocularis	peroxidasin	0.0038	0.0267	0.036
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0022	0.002
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0141	0.0178
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0069	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0106	1
Onchocerca volvulus		0.0038	0.0267	0.1426
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0034	0.0229	0.0299
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0022	0.009
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0267	0.036
Trichomonas vaginalis	helicase, putative	0.0014	0.0058	0.0056
Mycobacterium ulcerans	integral membrane transporter	0.0034	0.0229	0.0208
Schistosoma mansoni	DNA ligase IV	0.001	0.0022	0.0031
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0342	0.0467
Brugia malayi	hypothetical protein	0.004	0.028	0.0377
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.1152
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0262	0.0351
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.028	0.0377
Onchocerca volvulus		0.0038	0.0267	0.1426
Echinococcus multilocularis	cpg binding protein	0.0065	0.0499	0.0692
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0141	0.007
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0102	0.0122
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0017	0.0025
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0106	0.037
Schistosoma mansoni	hypothetical protein	0.034	0.2873	0.4119
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.034	0.2873	0.4105
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.034	0.2873	0.4105
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0141	0.0119
Onchocerca volvulus	Dual oxidase homolog	0.0038	0.0267	0.1426
Schistosoma mansoni	peroxidasin	0.0038	0.0267	0.0383
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0267	0.036
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0022	0.0017
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0141	0.0051
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0062	0.0468	0.0649
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0058	0.0056
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0007
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0058	0.0056
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0141	0.0581
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.034	0.2873	0.4105
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0141	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0815	0.6974	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0106	0.4061
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0815	0.6974	1
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0267	0.036
Trypanosoma brucei	carbonic anhydrase-like protein	0.0815	0.6974	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0017	0.0025
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0022	0.002
Schistosoma mansoni	hypothetical protein	0.0017	0.0087	0.0125
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.034	0.2873	0.4105
Onchocerca volvulus		0.0038	0.0267	0.1426
Toxoplasma gondii	hypothetical protein	0.034	0.2873	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0087	0.0101
Echinococcus multilocularis	carbonic anhydrase	0.034	0.2873	0.4105
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.009	0.001
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.034	0.2873	0.4105
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0022	0.002
Brugia malayi	Blistered cuticle protein 3	0.0038	0.0267	0.036
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0815	0.6974	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0022	0.0007
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0034	0.0229	0.0208
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0106	0.0438
Echinococcus granulosus	carbonic anhydrase II	0.0815	0.6974	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0058	0.0056
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0141	0.0119
Brugia malayi	hypothetical protein	0.001	0.0022	0.0007
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.0288	0.2427	1
Schistosoma mansoni	cpg binding protein	0.0065	0.0499	0.0715
Echinococcus granulosus	peroxidasin	0.0038	0.0267	0.036
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0069	0.0075
Schistosoma mansoni	cpg binding protein	0.0062	0.0468	0.0672
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0141	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0087	0.0101
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0106	0.0121
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0267	0.036
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0141	0.0178
Echinococcus granulosus	microtubule associated protein 2	0.0687	0.5866	0.8407
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Echinococcus multilocularis	dnaJ subfamily B	0.0451	0.3829	0.548
Mycobacterium ulcerans	carbonic anhydrase	0.0288	0.2427	0.241
Schistosoma mansoni	dishevelled	0.0009	0.0017	0.0025
Plasmodium falciparum	carbonic anhydrase	0.034	0.2873	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0058	0.0056
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0106	0.0104
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.009	0.3258
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0034	0.0229	0.0744
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0815	0.6974	1
Echinococcus multilocularis	carbonic anhydrase	0.034	0.2873	0.4105
Echinococcus granulosus	carbonic anhydrase	0.034	0.2873	0.4105
Brugia malayi	topoisomerase	0.001	0.0022	0.0007
Schistosoma mansoni	hypothetical protein	0.004	0.028	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0058	0.0056
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0022	0.0007
Plasmodium vivax	sulfate transporter, putative	0.0034	0.0229	1
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0135	0.1099	0.1185
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0399	0.3383	0.3844
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0141	0.0119
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0034	0.0229	0.0299
Echinococcus multilocularis	microtubule associated protein 2	0.0687	0.5866	0.8407
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0022	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.1166	1	1
Schistosoma mansoni	ap endonuclease	0.002	0.0106	0.0152
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0007
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0017	0.0025
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0087	0.0101
Schistosoma mansoni	carbonic anhydrase	0.034	0.2873	0.4119
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0087	0.0101
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0141	0.0051
Echinococcus granulosus	GPCR family 2	0.0017	0.0087	0.0101
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0069	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Onchocerca volvulus	Putative sulfate transporter	0.0212	0.1771	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0342	0.049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0007
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0087	0.0101
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0815	0.6974	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0022	0.0031
Loa Loa (eye worm)	carbonic anhydrase 3	0.0815	0.6974	1
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0034	0.0229	0.0208
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0034	0.0229	0.0799
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0022	0.0007
Brugia malayi	hypothetical protein	0.0038	0.0267	0.036
Schistosoma mansoni	carbonic anhydrase-related	0.034	0.2873	0.4119
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.034	0.2873	0.4105
Schistosoma mansoni	microtubule-associated protein tau	0.0687	0.5866	0.8411
Schistosoma mansoni	topbp1	0.001	0.0022	0.0031
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0106	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0022	0.002
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0117	0.0944	0.3244
Mycobacterium leprae	Probable transmembrane transport protein	0.0245	0.2056	0.8456
Schistosoma mansoni	hypothetical protein	0.0017	0.0087	0.0125
Onchocerca volvulus	Peroxidasin homolog	0.0038	0.0267	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Echinococcus granulosus	dnaJ subfamily B	0.0451	0.3829	0.548
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0342	0.049
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0034	0.0229	0.0299
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0106	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0141	0.0178
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.1012	0.8672	1
Brugia malayi	Peroxidasin	0.0038	0.0267	0.036
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0267	0.036
Chlamydia trachomatis	sulfate transporter	0.0034	0.0229	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0069	0.0099
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0007
Brugia malayi	N-terminal motif family protein	0.0188	0.1558	0.2215
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0141	0.0178
Schistosoma mansoni	peroxidasin	0.0038	0.0267	0.0383
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0141	0.0495
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0106	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Onchocerca volvulus	Peroxidase homolog	0.0038	0.0267	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1558	0.2215
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0141	0.0178
Entamoeba histolytica	carbonic anhydrase, putative	0.0288	0.2427	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0342	0.0467
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0342	0.0467
Brugia malayi	CXXC zinc finger family protein	0.0062	0.0468	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0262	0.0351
Loa Loa (eye worm)	hypothetical protein	0.034	0.2873	0.4105
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0342	0.0467
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0267	0.036
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0141	0.0119
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.028	0.0377
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0106	0.0029
Entamoeba histolytica	hypothetical protein	0.001	0.0022	0.009
Schistosoma mansoni	topbp1	0.001	0.0022	0.0031
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0014	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0022	0.002
Loa Loa (eye worm)	blistered cuticle protein 3	0.0038	0.0267	0.036
Schistosoma mansoni	dishevelled	0.0009	0.0017	0.0025
Schistosoma mansoni	ap endonuclease	0.002	0.0106	0.0152
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0342	0.049
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0245	0.2056	0.2298
Echinococcus granulosus	carbonic anhydrase	0.034	0.2873	0.4105
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0022	0.002
Schistosoma mansoni	cpg binding protein	0.0065	0.0499	0.0715
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.009	0.0068
Onchocerca volvulus		0.001	0.0022	0.0027
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0131	0.1064	0.1526
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.009	0.0312
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0267	0.036
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0058	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0141	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.0104
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0022	0.0076
Schistosoma mansoni	hypothetical protein	0.0017	0.0087	0.0125
Schistosoma mansoni	dep domain containing protein	0.0009	0.0017	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0069	0.0075
Onchocerca volvulus	Chorion peroxidase homolog	0.0038	0.0267	0.1426
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0106	0.0128
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.01	0.0119
Schistosoma mansoni	carbonic anhydrase	0.0288	0.2427	0.348
Onchocerca volvulus		0.0212	0.1771	1
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0267	0.036
Brugia malayi	DKFZp564C0469 protein	0.001	0.0022	0.0007
Toxoplasma gondii	exonuclease III APE	0.002	0.0106	0.0312
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0087	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0106	0.0084
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0102	0.0122
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0141	0.0119
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0141	0.007
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0412	0.0567
Schistosoma mansoni	hypothetical protein	0.0038	0.0262	0.0375
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0058	0.0056
Loa Loa (eye worm)	hypothetical protein	0.001	0.0022	0.0007
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0022	0.0007
Echinococcus granulosus	cpg binding protein	0.0065	0.0499	0.0692
Onchocerca volvulus		0.0062	0.0468	0.2573
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0022	0.002
Onchocerca volvulus	Peroxidase homolog	0.0038	0.0267	0.1426
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0022	0.0017
Echinococcus multilocularis	nibrin	0.001	0.0022	0.0007
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.034	0.2873	0.4105
Onchocerca volvulus		0.0024	0.0141	0.0706
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0106	0.0128
Schistosoma mansoni	hypothetical protein	0.0017	0.0087	0.0125
Schistosoma mansoni	carbonic anhydrase-related	0.034	0.2873	0.4119
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0267	0.036
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.034	0.2873	0.4105
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0106	0.0128
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.1152
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0106	0.0104
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0022	0.002
Schistosoma mansoni	hypothetical protein	0.0451	0.3829	0.5491
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0412	0.0567
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0342	0.0467

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1834176

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1136221