Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0009 | 0.0119 | 0.0119 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0534 | 0.0534 |
Plasmodium falciparum | apyrase, putative | 0.0057 | 0.1865 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0009 | 0.0119 | 0.0119 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Loa Loa (eye worm) | heterotrimeric G protein alpha subunit | 0.0009 | 0.0119 | 0.0464 |
Trichomonas vaginalis | guanosine-diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0014 | 0.0298 | 0.1028 |
Loa Loa (eye worm) | GTP-binding regulatory protein alpha chain | 0.0009 | 0.0119 | 0.0464 |
Trypanosoma cruzi | nucleoside phosphatase, putative | 0.0087 | 0.2929 | 1 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Leishmania major | ATP diphosphohydrolase | 0.0087 | 0.2929 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0187 | 0.0187 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0119 | 0.0464 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0011 | 0.0187 | 0.0068 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.0187 | 0.0832 |
Trypanosoma cruzi | nucleoside phosphatase, putative | 0.0057 | 0.1865 | 0.5953 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0541 | 0.2769 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0187 | 0.0386 |
Leishmania major | nucleoside phosphatase, putative,guanosine diphosphatase, putative | 0.0087 | 0.2929 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0119 | 0.0464 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0011 | 0.0187 | 0.0068 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.0728 | 0.0616 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.0057 | 0.1865 | 0.6366 |
Echinococcus granulosus | 3'partial|ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1865 | 1 |
Toxoplasma gondii | Nucleoside-diphosphatase | 0.0057 | 0.1865 | 0.6366 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0009 | 0.0119 | 0.0119 |
Echinococcus granulosus | ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0422 | 0.144 |
Schistosoma mansoni | P2X receptor subunit | 0.0284 | 1 | 1 |
Toxoplasma gondii | NTPase II | 0.0057 | 0.1865 | 0.6366 |
Schistosoma mansoni | adenosine diphosphatase | 0.0087 | 0.2929 | 0.2929 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0011 | 0.0187 | 0.0068 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0783 | 0.3803 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Schistosoma mansoni | ATP-diphosphohydrolase 1 | 0.0057 | 0.1865 | 0.1865 |
Plasmodium falciparum | nucleoside-diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0187 | 0.0832 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.1865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0119 | 0.0464 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.0087 | 0.2929 | 1 |
Trichomonas vaginalis | guanosine-diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.0728 | 0.3486 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0009 | 0.0119 | 0.0119 |
Echinococcus granulosus | ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0187 | 0.0187 |
Plasmodium vivax | nucleoside-diphosphatase mig-23, putative | 0.0057 | 0.1865 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0783 | 0.4091 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.0728 | 0.0616 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0187 | 0.0386 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0009 | 0.0119 | 0.3989 |
Trichomonas vaginalis | guanosine-diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.0728 | 0.3788 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.0728 | 0.3486 |
Trichomonas vaginalis | adenosine/guanosine diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0284 | 1 | 1 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Trypanosoma brucei | nucleoside diphosphatase, putative | 0.0087 | 0.2929 | 1 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.0057 | 0.1865 | 1 |
Trypanosoma brucei | nucleoside phosphatase, putative | 0.0087 | 0.2929 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0141 | 0.4861 | 0.4861 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.0728 | 0.3486 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0187 | 0.0637 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0284 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0141 | 0.4861 | 0.4861 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.0616 | 0.2558 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0284 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0011 | 0.0187 | 0.0068 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0057 | 0.1865 | 0.1767 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0284 | 1 | 1 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.0057 | 0.1865 | 0.6366 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0009 | 0.0119 | 0.0119 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0187 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0298 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.1865 | 1 |
Brugia malayi | Nucleoside-diphosphatase mig-23 | 0.0057 | 0.1865 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0187 | 0.0637 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0284 | 1 | 1 |
Schistosoma mansoni | guanosine-diphosphatase | 0.0057 | 0.1865 | 0.1865 |
Schistosoma mansoni | guanosine-diphosphatase | 0.0057 | 0.1865 | 0.1865 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Percentage inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of bovine brain membranes | ChEMBL. | 7783151 |
Inhibition (binding) | = 0 % | Percentage inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of bovine brain membranes | ChEMBL. | 7783151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.