Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1626 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.183 | 0.1118 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1626 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1626 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0801 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1231 | 0.0467 |
Brugia malayi | Bromodomain containing protein | 0.008 | 0.4346 | 0.408 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.9296 | 0.9235 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1984 | 0.1285 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1492 | 0.109 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.1176 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.9296 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1626 | 0.1846 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3156 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1626 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3156 | 0.3395 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.9296 | 0.9263 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0801 | 0.0862 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1984 | 0.1606 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3747 | 0.3203 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0035 | 0.0038 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1984 | 0.1606 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.1176 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.8808 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.1176 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0035 | 0.004 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0035 | 0.0038 |
Onchocerca volvulus | 0.0154 | 1 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.9296 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1041 | 0.1182 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1626 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1681 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1984 | 0.1285 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1041 | 0.112 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.3435 | 0.3695 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 4 % | Growth inhibition of human CCRF-CEM cells at 10 uM after 2 days by MTT assay | ChEMBL. | 20570145 |
Inhibition (functional) | = 7 % | Growth inhibition of human HCT116 cells at 10 uM after 2 days by MTT assay | ChEMBL. | 20570145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.