Detailed information for compound 1144393

Basic information

Technical information
  • TDR Targets ID: 1144393
  • Name: N-[2-[2-methoxy-4-(2-phenylethoxy)phenyl]ethy l]-N-propylpropan-1-amine
  • MW: 355.514 | Formula: C23H33NO2
  • H donors: 0 H acceptors: 0 LogP: 5.91 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(CCc1ccc(cc1OC)OCCc1ccccc1)CCC
  • InChi: 1S/C23H33NO2/c1-4-15-24(16-5-2)17-13-21-11-12-22(19-23(21)25-3)26-18-14-20-9-7-6-8-10-20/h6-12,19H,4-5,13-18H2,1-3H3
  • InChiKey: VOGHRFUPPGCETI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[2-methoxy-4-(2-phenylethoxy)phenyl]ethyl]-N-propyl-propan-1-amine
  • 2-[2-methoxy-4-(2-phenylethoxy)phenyl]ethyl-dipropyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0037 0.0402 0.0402
Mycobacterium ulcerans glutaminase 0.0281 0.5331 1
Brugia malayi RNA, U transporter 1 0.0082 0.1304 0.1304
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0402 0.3307
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1051 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0642 0.0642
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0512 1 1
Schistosoma mansoni tar DNA-binding protein 0.0512 1 1
Schistosoma mansoni importin beta-1 0.0029 0.0234 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0402 0.0402
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0529 0.0529
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0192 0.1149
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0343 0.2862
Loa Loa (eye worm) hypothetical protein 0.0066 0.0996 0.0996
Echinococcus granulosus pyruvate kinase 0.0066 0.0996 0.0996
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0402 0.0402
Plasmodium falciparum importin beta, putative 0.0029 0.0234 0.1673
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.1051 0.1051
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0402 0.3505
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0124 0.0083
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0564 0.5282
Echinococcus multilocularis tumor protein p63 0.0338 0.6492 0.6492
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0234 0.1579
Entamoeba histolytica hypothetical protein 0.0023 0.0124 0.0436
Giardia lamblia Pyruvate kinase 0.0034 0.0343 0.2862
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.2749 0.2749
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.1051 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0996 0.9435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0642 0.0642
Toxoplasma gondii ABC1 family protein 0.0037 0.0402 0.3505
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0489 0.4453
Schistosoma mansoni pyruvate kinase 0.0066 0.0996 0.0996
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0463 0.0463
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.1051 0.1051
Schistosoma mansoni hypothetical protein 0.0043 0.0529 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0512 1 1
Schistosoma mansoni glutaminase 0.0281 0.5331 0.5331
Schistosoma mansoni pyruvate kinase 0.0034 0.0343 0.0343
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.473 0.473
Loa Loa (eye worm) glutaminase 0.0281 0.5331 0.5331
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0124 0.0448
Brugia malayi RNA recognition motif domain containing protein 0.0512 1 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.0529 0.4898
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0343 0.2862
Loa Loa (eye worm) hypothetical protein 0.0043 0.0529 0.0529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0642 0.0642
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.073 0.073
Entamoeba histolytica hypothetical protein 0.007 0.1077 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.1051 0.1051
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.5846 0.5846
Schistosoma mansoni hypothetical protein 0.007 0.1077 0.1077
Trypanosoma brucei pyruvate kinase 1, putative 0.0066 0.0996 0.9435
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.059 0.511
Leishmania major pyruvate kinase 0.0066 0.0996 0.9435
Leishmania major importin beta-1 subunit, putative 0.0023 0.0124 0.0448
Schistosoma mansoni pyruvate kinase 0.0066 0.0996 0.0996
Loa Loa (eye worm) glutaminase 2 0.0281 0.5331 0.5331
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0402 0.0402
Echinococcus multilocularis pyruvate kinase 0.0052 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0037 0.0402 0.0402
Brugia malayi glutaminase DH11.1 0.0281 0.5331 0.5331
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0081 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0306 0.5846 0.5846
Loa Loa (eye worm) hypothetical protein 0.0036 0.039 0.039
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.006 0.006
Trypanosoma brucei pyruvate kinase 1 0.0066 0.0996 0.9435
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0402 0.0402
Echinococcus granulosus tar DNA binding protein 0.0512 1 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0234 0.0234
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0529 0.0529
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0402 0.0402
Echinococcus multilocularis geminin 0.0168 0.304 0.304
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0642 0.0642
Toxoplasma gondii pyruvate kinase PyK1 0.0066 0.0996 1
Schistosoma mansoni tar DNA-binding protein 0.0512 1 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0343 0.0343
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.059 0.059
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.1051 0.1051
Echinococcus multilocularis snurportin 1 0.0306 0.5846 0.5846
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0234
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0192 0.1149
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0343 0.2862
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0192 0.1217
Echinococcus granulosus pyruvate kinase 0.0066 0.0996 0.0996
Entamoeba histolytica hypothetical protein 0.007 0.1077 1
Echinococcus multilocularis pyruvate kinase 0.0066 0.0996 0.0996
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0081 0.0081
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0081 0.0081
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0655 0.0655
Leishmania major pyruvate kinase 0.0066 0.0996 0.9435
Schistosoma mansoni hypothetical protein 0.0036 0.039 0.039
Brugia malayi beta-lactamase family protein 0.0037 0.0402 0.0402
Echinococcus granulosus geminin 0.0168 0.304 0.304
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0996 0.0996
Schistosoma mansoni tar DNA-binding protein 0.0512 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0402 0.0611
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0402 0.3307
Brugia malayi hypothetical protein 0.0039 0.0444 0.0444
Brugia malayi hypothetical protein 0.007 0.1077 0.1077
Echinococcus granulosus pyruvate kinase 0.0034 0.0343 0.0343
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0529 0.4898
Loa Loa (eye worm) hypothetical protein 0.0053 0.073 0.073
Schistosoma mansoni ran 0.0021 0.0081 0.0081
Echinococcus multilocularis pyruvate kinase 0.0034 0.0343 0.0343
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0234 0.1673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0642 0.0642
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1051 1
Echinococcus granulosus snurportin 1 0.0306 0.5846 0.5846
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.1077 0.1077
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.2663 0.2663
Echinococcus multilocularis tar DNA binding protein 0.0512 1 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0234 0.1673
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.473 0.473
Mycobacterium leprae Probable pyruvate kinase PykA 0.0066 0.0996 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0642 0.0642
Brugia malayi Pyruvate kinase, M2 isozyme 0.0066 0.0996 0.0996
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0996 0.0996
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1051 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0529 0.0529
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0996 0.9435
Loa Loa (eye worm) hypothetical protein 0.0037 0.0402 0.0402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0642 0.0642
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0564 0.5282
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.1051 0.1051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0066 0.0996 0.0996
Echinococcus granulosus tumor protein p63 0.0338 0.6492 0.6492
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0066 0.0996 0.1475
Schistosoma mansoni ran 0.0021 0.0081 0.0081
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0124 0.0083
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0996 0.1743
Loa Loa (eye worm) beta-lactamase 0.0037 0.0402 0.0402
Schistosoma mansoni transcription factor LCR-F1 0.007 0.1077 0.1077
Echinococcus granulosus pyruvate kinase 0.0034 0.0343 0.0343
Plasmodium falciparum pyruvate kinase 0.0066 0.0996 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0343 0.0343
Schistosoma mansoni hypothetical protein 0.0168 0.304 0.304
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.2749 0.2749
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0564 0.0921
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0124 0.0083
Brugia malayi hypothetical protein 0.0039 0.0444 0.0444
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0402 0.0611
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0192 0.1217
Echinococcus granulosus transcription factor Dp 1 0.004 0.0463 0.0463
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0402 0.3307
Brugia malayi hypothetical protein 0.0027 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.007 0.1077 1
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0996 1
Leishmania major hypothetical protein, conserved 0.0037 0.0402 0.3307
Brugia malayi TAR-binding protein 0.0512 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0402 0.0611
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0642 0.0642
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.2749 0.2749
Loa Loa (eye worm) hypothetical protein 0.0037 0.0402 0.0402
Trichomonas vaginalis glutaminase, putative 0.0281 0.5331 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0642 0.0642
Brugia malayi beta-lactamase 0.0037 0.0402 0.0402
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0081 0.0081
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0234 0.0234
Echinococcus multilocularis pyruvate kinase 0.0066 0.0996 0.0996
Loa Loa (eye worm) hypothetical protein 0.0037 0.0402 0.0402
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0996 1
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0529 0.0529
Onchocerca volvulus 0.005 0.0655 0.426
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.073 0.073
Entamoeba histolytica hypothetical protein 0.007 0.1077 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0192 0.1217
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0402 0.0611
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0234 0.1579
Echinococcus granulosus importin subunit beta 1 0.0029 0.0234 0.0234
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0192 0.1149
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0489 0.4453
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0402 0.0402
Schistosoma mansoni hypothetical protein 0.0168 0.304 0.304
Giardia lamblia Pyruvate kinase 0.0066 0.0996 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0402 0.0402
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0996 0.0996
Loa Loa (eye worm) TAR-binding protein 0.0512 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.073 0.073
Brugia malayi MH2 domain containing protein 0.0251 0.473 0.473
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0192
Chlamydia trachomatis pyruvate kinase 0.0066 0.0996 0.5
Leishmania major hypothetical protein, conserved 0.0027 0.0192 0.1149
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.1077 0.1077
Loa Loa (eye worm) RNA binding protein 0.0512 1 1
Schistosoma mansoni tar DNA-binding protein 0.0512 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.4431 1
Mycobacterium ulcerans pyruvate kinase 0.0066 0.0996 0.1206
Loa Loa (eye worm) acetyltransferase 0.0153 0.2749 0.2749
Loa Loa (eye worm) hypothetical protein 0.0037 0.0402 0.0402
Plasmodium vivax pyruvate kinase, putative 0.0066 0.0996 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0564 0.0921
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0529 0.4898
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0402 0.0611
Loa Loa (eye worm) hypothetical protein 0.005 0.0655 0.0655
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0564 0.5282
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0996 0.1743
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0192 0.1217
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.1051 0.9736
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0489 0.409
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0046 0.059 0.059
Trichomonas vaginalis esterase, putative 0.0037 0.0402 0.0611
Echinococcus multilocularis pyruvate kinase 0.0034 0.0343 0.0343

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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