Detailed information for compound 1145775

Basic information

Technical information
  • TDR Targets ID: 1145775
  • Name: 5-methoxy-N-phenyl-1,2,3,4-tetrahydronaphthal en-2-amine
  • MW: 253.339 | Formula: C17H19NO
  • H donors: 1 H acceptors: 0 LogP: 4.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1CCC(C2)Nc1ccccc1
  • InChi: 1S/C17H19NO/c1-19-17-9-5-6-13-12-15(10-11-16(13)17)18-14-7-3-2-4-8-14/h2-9,15,18H,10-12H2,1H3
  • InChiKey: HILLIWGRBNEAJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methoxy-N-phenyl-tetralin-2-amine
  • 5-methoxy-N-phenyl-2-tetralinamine
  • (5-methoxytetralin-2-yl)-phenyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0088 0.0195 0.0154
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.008 0.3831
Onchocerca volvulus Huntingtin homolog 0.0127 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.0035
Echinococcus multilocularis expressed conserved protein 0.0094 0.0212 0.0171
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0618 0.1715 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0048
Echinococcus multilocularis pyruvate kinase 0.0068 0.0136 0.0096
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.008 0.3831
Onchocerca volvulus Huntingtin homolog 0.0127 0.0305 1
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0136 0.0435
Mycobacterium leprae Probable pyruvate kinase PykA 0.0068 0.0136 0.4922
Plasmodium falciparum cation/H+ antiporter 0.0088 0.0195 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0081 0.004
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0065 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0353 0.0313
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0119 0.0078
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.008 0.3831
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0093 0.0049
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0136 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0081 0.004
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0065 0.0024
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0088 0.0195 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.008 0.3831
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0136 0.0092
Loa Loa (eye worm) hypothetical protein 0.0101 0.0229 0.0186
Loa Loa (eye worm) hypothetical protein 0.0088 0.0195 0.0151
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.0077 0.1476
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.0077 0.0033
Leishmania major pyruvate kinase 0.0068 0.0136 1
Schistosoma mansoni hypothetical protein 0.0042 0.006 0.0019
Schistosoma mansoni hypothetical protein 0.0042 0.006 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.008 0.262
Giardia lamblia Pyruvate kinase 0.0068 0.0136 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0065 0.002
Brugia malayi AMP-binding enzyme family protein 0.0048 0.008 0.0201
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0088 0.0195 0.0491
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0081 0.0036
Brugia malayi Sodium/calcium exchanger protein 0.1402 0.3965 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0828 0.2318 0.2286
Brugia malayi AMP-binding enzyme family protein 0.0048 0.008 0.0201
Loa Loa (eye worm) hypothetical protein 0.0068 0.0136 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0119 0.8083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0081 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0119 0.8083
Echinococcus granulosus expressed conserved protein 0.0094 0.0212 0.0171
Schistosoma mansoni sodium/calcium exchanger 0.3504 1 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0068 0.0136 0.0344
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0051 0.001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0234 0.0193
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0051 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0119 0.0078
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0088 0.0195 1
Plasmodium vivax pyruvate kinase, putative 0.0068 0.0136 0.6199
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.008 0.3831
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0088 0.0195 0.0151
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0088 0.0195 0.5108
Toxoplasma gondii manganese resistance 1 protein, putative 0.0088 0.0195 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.008 0.3831
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0093 0.0235
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0136 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0195 0.0788
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0229 0.0579
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0119 0.0078
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.008 0.1621
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.002
Trypanosoma brucei pyruvate kinase 1, putative 0.0068 0.0136 0.5
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.008 0.262
Brugia malayi hypothetical protein 0.0038 0.0051 0.0128
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0136 0.2514
Echinococcus multilocularis protein patched 0.0043 0.0065 0.0024
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0088 0.0195 0.0154
Echinococcus multilocularis protein dispatched 1 0.0049 0.0082 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0051 0.001
Schistosoma mansoni hypothetical protein 0.0088 0.0195 0.0154
Treponema pallidum hypothetical protein 0.0088 0.0195 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0049
Schistosoma mansoni hypothetical protein 0.0042 0.006 0.0019
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0119 0.5054
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0195 0.0788
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0045 0.0114
Loa Loa (eye worm) solute carrier family 8 0.3504 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.008 0.1621
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0045 0.0226
Loa Loa (eye worm) hypothetical protein 0.0088 0.0195 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0081 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0081 0.004
Schistosoma mansoni na/ca exchanger 0.0088 0.0195 0.0154
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0229 0.0189
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0353 0.0313
Echinococcus multilocularis sodium calcium exchanger 0.3504 1 1
Plasmodium falciparum pyruvate kinase 0.0068 0.0136 0.6199
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0045 0.0226
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0088 0.0195 0.0154
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0229 1
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0088 0.0195 0.0154
Brugia malayi Pyruvate kinase, muscle isozyme 0.0068 0.0136 0.0344
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0119 0.5124
Leishmania major pyruvate kinase 0.0068 0.0136 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0119 0.6893
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0119 0.0078
Brugia malayi CHE-14 protein 0.0043 0.0065 0.0163
Schistosoma mansoni hypothetical protein 0.0042 0.006 0.0019
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0136 0.0092
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0065 0.0024
Plasmodium vivax cation/H+ antiporter, putative 0.0088 0.0195 1
Brugia malayi hypothetical protein 0.0127 0.0305 0.0769
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0136 0.5
Echinococcus multilocularis pyruvate kinase 0.0054 0.0095 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0081 0.004
Schistosoma mansoni hypothetical protein 0.0036 0.0045 0.0004
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0088 0.0195 0.0154
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0136 0.2514
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0229 0.0189
Schistosoma mansoni pyruvate kinase 0.0068 0.0136 0.0096
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0088 0.0195 0.8059
Chlamydia trachomatis pyruvate kinase 0.0068 0.0136 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0618 0.1715 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.008 0.1621
Schistosoma mansoni patched 1 0.0043 0.0065 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0093 0.0235
Echinococcus granulosus pyruvate kinase 0.0068 0.0136 0.0096
Mycobacterium ulcerans hypothetical protein 0.0048 0.008 0.3831
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0136 0.0092
Loa Loa (eye worm) hypothetical protein 0.1402 0.3965 0.3938
Schistosoma mansoni hypothetical protein 0.0038 0.0051 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.0035
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0068 0.0136 0.6253
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0088 0.0195 0.0491
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0045 0.0364
Loa Loa (eye worm) hypothetical protein 0.0127 0.0305 0.0261
Trypanosoma brucei pyruvate kinase 1 0.0068 0.0136 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0119 0.8083
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0088 0.0195 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0048 0.008 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.008 0.3831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0081 0.004
Echinococcus multilocularis pyruvate kinase 0.0068 0.0136 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0195 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0195 0.0788
Schistosoma mansoni pyruvate kinase 0.0068 0.0136 0.0096
Mycobacterium ulcerans pyruvate kinase 0.0068 0.0136 1
Echinococcus granulosus pyruvate kinase 0.0068 0.0136 0.0096
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0136 0.2514
Toxoplasma gondii pyruvate kinase PyK1 0.0068 0.0136 0.6199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0081 0.004
Loa Loa (eye worm) hypothetical protein 0.0127 0.0305 0.0261

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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