TDR Targets

Basic information

Technical information

TDR Targets ID: 1146393
Name: 2-[(3-bromo-4-methoxyphenyl)methylideneamino] -1-hydroxyguanidine
MW: 287.113 | Formula: C9H11BrN4O2
H donors: 3 H acceptors: 1 LogP: 1.26 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=N)N/N=C/c1ccc(c(c1)Br)OC
InChi: 1S/C9H11BrN4O2/c1-16-8-3-2-6(4-7(8)10)5-12-13-9(11)14-15/h2-5,15H,1H3,(H3,11,13,14)/b12-5+
InChiKey: VEMNKZWDQAILNC-LFYBBSHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(3-bromo-4-methoxy-phenyl)methyleneamino]-1-hydroxy-guanidine
2-[(3-bromo-4-methoxyphenyl)methyleneamino]-1-hydroxyguanidine
2-[(3-bromo-4-methoxy-benzylidene)amino]-1-hydroxy-guanidine
2-[(3-bromo-4-methoxy-phenyl)methylideneamino]-1-hydroxy-guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0217	0.087	0.0839
Echinococcus multilocularis	cytosolic carboxypeptidase protein 5	0.0125	0.0379	0.0346
Toxoplasma gondii	hypothetical protein	0.0156	0.0547	1
Schistosoma mansoni	metallocarboxypeptidase D peptidase unit 2 (M14 family)	0.0125	0.0379	0.0967
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Toxoplasma gondii	flagellar/basal body protein	0.0125	0.0379	0.6713
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0125	0.0379	0.4123
Echinococcus granulosus	cytosolic carboxypeptidase 1	0.0125	0.0379	0.0346
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0547	0.6141
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0156	0.0547	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0065	0.0058	0.0068
Toxoplasma gondii	zinc carboxypeptidase, putative	0.0125	0.0379	0.6713
Schistosoma mansoni	protease m14 carboxypeptidase	0.0125	0.0379	0.0967
Plasmodium vivax	hypothetical protein, conserved	0.0125	0.0379	0.6713
Mycobacterium leprae	conserved hypothetical protein	0.0156	0.0547	0.5
Schistosoma mansoni	hypothetical protein	0.0187	0.071	0.1898
Mycobacterium ulcerans	putative regulatory protein	0.0156	0.0547	0.5
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0217	0.087	1
Schistosoma mansoni	carboxypeptidase N (M14 family)	0.0125	0.0379	0.0967
Schistosoma mansoni	peptidase	0.0125	0.0379	0.0967
Onchocerca volvulus		0.0727	0.3598	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0065	0.0058	0.0024
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Schistosoma mansoni	hypothetical protein	0.0187	0.071	0.1898
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.1925	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0065	0.0058	0.0068
Toxoplasma gondii	hypothetical protein	0.0156	0.0547	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	hypothetical protein	0.0217	0.087	0.0867
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Brugia malayi	Carboxypeptidase A2 precursor	0.0125	0.0379	0.0379
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0547	0.6141
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Plasmodium vivax	hypothetical protein, conserved	0.0156	0.0547	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0158	0.0129
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Schistosoma mansoni	hypothetical protein	0.0125	0.0379	0.0967
Echinococcus granulosus	subfamily M14A unassigned peptidase	0.0727	0.3598	0.3576
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.006	0.0034	0.0034
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trypanosoma cruzi	zinc carboxypeptidase, putative	0.0125	0.0379	0.4123
Echinococcus granulosus	lysine specific demethylase 5A	0.0065	0.0058	0.0024
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Giardia lamblia	Nuclear ATP/GTP-binding protein	0.0125	0.0379	1
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Echinococcus multilocularis	lysine specific demethylase 5A	0.0065	0.0058	0.0024
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0058	0.0025
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	zinc carboxypeptidase	0.0125	0.0379	0.0357
Schistosoma mansoni	peptidase	0.0125	0.0379	0.0967
Toxoplasma gondii	zinc carboxypeptidase superfamily protein	0.0125	0.0379	0.6713
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0125	0.0379	0.4123
Schistosoma mansoni	subfamily M14A unassigned peptidase (M14 family)	0.0727	0.3598	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.006	0.0034	0.0034
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.1925	1	1
Onchocerca volvulus	Subfamily M14A unassigned peptidase homolog	0.0727	0.3598	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.006	0.0034	0.0034
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1845	0.9573	0.9572
Plasmodium falciparum	GAF domain-related protein, putative	0.0156	0.0547	1
Echinococcus granulosus	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0346
Trypanosoma cruzi	PAB1-binding protein , putative	0.0084	0.0158	0.1486
Echinococcus granulosus	geminin	0.0187	0.071	0.0679
Brugia malayi	jmjC domain containing protein	0.0065	0.0058	0.0058
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	hypothetical protein	0.1865	0.9677	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	hypothetical protein	0.1709	0.8842	0.9133
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0217	0.087	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14, putative	0.0125	0.0379	0.4123
Mycobacterium ulcerans	putative regulatory protein	0.0156	0.0547	0.5
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0156	0.0547	0.5
Brugia malayi	hypothetical protein	0.0084	0.0158	0.0158
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0217	0.087	1
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Onchocerca volvulus		0.0727	0.3598	1
Trypanosoma cruzi	Carboxypeptidase-like protein	0.0125	0.0379	0.4123
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14, putative	0.0125	0.0379	0.4123
Echinococcus multilocularis	geminin	0.0187	0.071	0.0679
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0217	0.087	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0602	0.2931	0.3004
Echinococcus multilocularis	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0346
Trypanosoma brucei	metallo-peptidase, Clan MC, Family M14, putative	0.0125	0.0379	0.4123
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Giardia lamblia	Nuclear ATP/GTP-binding protein	0.0125	0.0379	1
Onchocerca volvulus		0.0727	0.3598	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.006	0.0034	0.0034
Trypanosoma brucei	Carboxypeptidase-like protein	0.0125	0.0379	0.4123
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0217	0.087	1
Trypanosoma brucei	metallo-peptidase, Clan MC, Family M14, putative	0.0125	0.0379	0.4123
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Toxoplasma gondii	LsmAD domain-containing protein	0.0084	0.0158	0.242
Loa Loa (eye worm)	zinc carboxypeptidase	0.0125	0.0379	0.0357
Schistosoma mansoni	peptidase	0.0125	0.0379	0.0967
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Giardia lamblia	Nuclear ATP/GTP-binding protein	0.0125	0.0379	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0217	0.087	0.087
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14	0.0125	0.0379	0.4123
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0065	0.0058	0.0024
Leishmania major	hypothetical protein, conserved	0.0084	0.0158	0.1486
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0217	0.087	0.2346
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Echinococcus granulosus	cytosolic carboxypeptidase protein 5	0.0125	0.0379	0.0346
Echinococcus multilocularis	subfamily M14A unassigned peptidase	0.0727	0.3598	0.3576
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Plasmodium vivax	ataxin-2 like protein, putative	0.0084	0.0158	0.242
Loa Loa (eye worm)	zinc carboxypeptidase	0.0125	0.0379	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Trypanosoma cruzi	PAB1-binding protein , putative	0.0084	0.0158	0.1486
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0065	0.0058	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0156	0.0547	0.5
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Plasmodium falciparum	ataxin-2 like protein, putative	0.0084	0.0158	0.242
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Loa Loa (eye worm)	zinc carboxypeptidase	0.0125	0.0379	0.0357
Schistosoma mansoni	family M14 non-peptidase homologue (M14 family)	0.0125	0.0379	0.0967
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Toxoplasma gondii	hypothetical protein	0.0156	0.0547	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0217	0.087	1
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0125	0.0379	0.4123
Trichomonas vaginalis	conserved hypothetical protein	0.0217	0.087	1
Onchocerca volvulus		0.0727	0.3598	1
Echinococcus multilocularis		0.0125	0.0379	0.0346
Trypanosoma brucei	PAB1-binding protein , putative	0.0084	0.0158	0.1486
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0379	0.0357
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0217	0.087	0.2346
Plasmodium falciparum	ataxin-2 like protein, putative	0.0084	0.0158	0.242
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1
Toxoplasma gondii	GAF domain-containing protein	0.0156	0.0547	1
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0547	0.6141
Brugia malayi	Zinc carboxypeptidase family protein	0.0125	0.0379	0.0379
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Toxoplasma gondii	zinc carboxypeptidase superfamily protein	0.0125	0.0379	0.6713
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0547	0.6141
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0125	0.0379	0.4123
Brugia malayi	jmjC domain containing protein	0.0065	0.0058	0.0058
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0217	0.087	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1160859

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1146393