TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.434 | Formula: C22H21N5O2
H donors: 0 H acceptors: 4 LogP: 3.45 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(n1)COc1nn2c(nnc2c2c1C1CCC2CC1)c1cocc1
InChi: 1S/C22H21N5O2/c1-13-3-2-4-17(23-13)12-29-22-19-15-7-5-14(6-8-15)18(19)21-25-24-20(27(21)26-22)16-9-10-28-11-16/h2-4,9-11,14-15H,5-8,12H2,1H3
InChiKey: BTESADIOSMFPBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, beta 3	Starlite/ChEMBL	References
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, gamma 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131775	All targets in OG5_131775
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	Get druggable targets OG5_129441	All targets in OG5_129441
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129441	All targets in OG5_129441
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129441	All targets in OG5_129441

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, gamma 2	467 aa	449 aa	27.6 %
Brugia malayi	excitatory GABA receptor EXP-1A	gamma-aminobutyric acid (GABA) A receptor, beta 3	473 aa	441 aa	29.9 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0544	0.5544	0.4431
Trypanosoma cruzi	cysteine peptidase, putative	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0544	0.5544	0.4431
Brugia malayi	Papain family cysteine protease containing protein	0.0423	0.3464	0.3222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Giardia lamblia	Cathepsin B precursor	0.0337	0.1998	0.5
Brugia malayi	cathepsin L-like precursor	0.0544	0.5544	0.5379
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3345	0.3345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0423	0.3464	0.1833
Onchocerca volvulus		0.0804	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Toxoplasma gondii	cathepsin CPL	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0337	0.1998	0.1416
Onchocerca volvulus		0.0804	1	1
Onchocerca volvulus		0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0804	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0726	0.8674	0.8625
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0804	1	1
Plasmodium vivax	vivapain-2	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Echinococcus multilocularis	cathepsin b	0.0726	0.8674	0.7971
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0804	1	1
Loa Loa (eye worm)	cysteine protease	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.0544	0.5544	0.5544
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0423	0.3464	0.1833
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Echinococcus granulosus	cathepsin l1	0.0544	0.5544	0.3182
Entamoeba histolytica	cysteine proteinase, putative	0.0804	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0804	1	1
Plasmodium vivax	vivapain-1	0.0423	0.3464	0.2989
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Echinococcus granulosus	cathepsin b	0.0726	0.8674	0.7971
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0337	0.1998	0.1416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Echinococcus granulosus	cathepsin b	0.0726	0.8674	0.7971
Trypanosoma cruzi	cysteine peptidase, putative	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.026	0.0678	0.0678
Entamoeba histolytica	cysteine protease, putative	0.0804	1	1
Onchocerca volvulus		0.0804	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0423	0.3464	0.1833
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0804	1	1
Plasmodium vivax	unspecified product	0.0423	0.3464	0.2989
Trypanosoma cruzi	cysteine peptidase, putative	0.0804	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0726	0.8674	0.8578
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0357	0.0357
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0804	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0544	0.5544	0.3182
Loa Loa (eye worm)	ctsf protein	0.0804	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0804	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0804	1	1
Giardia lamblia	Cathepsin B precursor	0.0337	0.1998	0.5
Leishmania major	cathepsin L-like protease	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0544	0.5544	0.5379
Loa Loa (eye worm)	hypothetical protein	0.026	0.0678	0.0678
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0544	0.5544	0.5379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0804	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Leishmania major	cathepsin L-like protease	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0726	0.8674	0.8578
Leishmania major	cathepsin L-like protease	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0726	0.8674	0.8578
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0423	0.3464	0.2989
Leishmania major	cathepsin L-like protease	0.0804	1	1
Echinococcus multilocularis	cathepsin b	0.0726	0.8674	0.7971
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0804	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.0804	1	1
Onchocerca volvulus		0.0804	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0804	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0423	0.3464	0.2989
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Echinococcus multilocularis	cysteine protease	0.0804	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0423	0.3464	0.3222
Plasmodium vivax	vivapain-3	0.0423	0.3464	0.2989
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0804	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0726	0.8674	0.8578
Leishmania major	cathepsin L-like protease	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0804	1	1
Echinococcus multilocularis	cysteine protease	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.0544	0.5544	0.5544
Leishmania major	cathepsin L-like protease	0.0804	1	1
Loa Loa (eye worm)	fibroinase	0.0804	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0804	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0423	0.3464	0.2989
Trypanosoma cruzi	cysteine proteinase, putative	0.0423	0.3464	0.2989
Leishmania major	cathepsin L-like protease	0.0804	1	1
Onchocerca volvulus		0.0804	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0544	0.5544	0.522
Trypanosoma cruzi	cysteine protease, putative	0.0423	0.3464	0.2989
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0804	1	1
Echinococcus granulosus	cathepsin l1	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.0726	0.8674	0.8674
Loa Loa (eye worm)	cathepsin B	0.0337	0.1998	0.1998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Giardia lamblia	Cathepsin B precursor	0.0337	0.1998	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0804	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0544	0.5544	0.522
Brugia malayi	cathepsin F-like cysteine proteinase	0.026	0.0678	0.0333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.026	0.0678	0.0333
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0726	0.8674	0.8578
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0423	0.3464	0.2989
Onchocerca volvulus	Cathepsin L homolog	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.0544	0.5544	0.5544
Trypanosoma cruzi	cysteine proteinase, putative	0.0423	0.3464	0.2989
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Leishmania major	cathepsin L-like protease	0.0804	1	1
Plasmodium vivax	vivapain-2	0.0804	1	1
Loa Loa (eye worm)	hypothetical protein	0.026	0.0678	0.0678
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0804	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.0544	0.5544	0.5379
Onchocerca volvulus		0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0804	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0423	0.3464	0.1833
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0804	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0423	0.3464	0.2989
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0804	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.026	0.0678	0.0678
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0804	1	1
Brugia malayi	Cathepsin L-like precursor	0.026	0.0678	0.0333

Activities

Activity type	Activity value	Assay description	Source	Reference
Efficacy (binding)	= -24 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha5-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= -24 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha5-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (binding)	= -24 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha5-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= -24 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha5-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (binding)	= -6 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha2-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (binding)	= -6 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha2-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= -5 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha2-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (functional)	= -5 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha2-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (binding)	= -4 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha3-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= -4 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha3-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (binding)	= -4 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha3-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= -4 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha3-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (binding)	= 27 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha1-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= 27 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha1-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Efficacy (binding)	= 27 %	Percentage modulation of submaximal (EC20) response to GABA in Xenopus oocytes expressing human GABA-A alpha1-beta3-gamma2 subunits	ChEMBL.	15084116
Efficacy (functional)	= 27 %	Percent change in electrophysiological response in Xenopus oocytes expressing Alpha1-beta3-gamma2 GABA-A receptor	ChEMBL.	15214791
Ki (binding)	= 3.1 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha5-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 3.1 nM	Binding affinity towards human alpha5-beta3-gamma2 GABA-A receptor using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 3.1 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha5-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 3.1 nM	Binding affinity towards human alpha5-beta3-gamma2 GABA-A receptor using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 40 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha3-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 40 nM	Binding affinity towards human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 40 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha3-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 40 nM	Binding affinity towards human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 63 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha2-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 63 nM	Binding affinity towards human gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 63 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha2-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 63 nM	Binding affinity towards human gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 250 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha1-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 250 nM	Binding affinity towards human alpha1-beta3-gamma2 GABA-A receptor using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791
Ki (binding)	= 250 nM	Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha1-beta3-gamma2 receptor subunits expressed in Xenopus oocytes	ChEMBL.	15084116
Ki (binding)	= 250 nM	Binding affinity towards human alpha1-beta3-gamma2 GABA-A receptor using [3H]-Ro-15-1788 expressed in L(tk-) cells	ChEMBL.	15214791

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11452020

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 114726