Detailed information for compound 1149521

Basic information

Technical information
  • TDR Targets ID: 1149521
  • Name: N-[(2-chlorophenyl)methyl]butan-1-amine
  • MW: 197.704 | Formula: C11H16ClN
  • H donors: 1 H acceptors: 0 LogP: 3.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNCc1ccccc1Cl
  • InChi: 1S/C11H16ClN/c1-2-3-8-13-9-10-6-4-5-7-11(10)12/h4-7,13H,2-3,8-9H2,1H3
  • InChiKey: PUEUFOKKVOOXEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • butyl-(2-chlorobenzyl)amine
  • 16183-39-4
  • 16183-40-7 (HYDROCHLORIDE)
  • AIDS-107179
  • AIDS107179
  • Benzenemethanamine, N-butyl-2-chloro-
  • STK294165

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0066 0.0359 1
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0134 0.0994 0.0994
Echinococcus multilocularis dual specificity protein kinase clk2 0.0066 0.0359 0.0359
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0281 0.2358 0.2358
Onchocerca volvulus 0.0031 0.0033 1
Giardia lamblia Kinase, CMGC CLK 0.0066 0.0359 0.5
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0066 0.0359 0.5
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0194 0.1551 1
Echinococcus granulosus lamin 0.0031 0.0033 0.0033
Echinococcus multilocularis musashi 0.0031 0.0033 0.0033
Brugia malayi Protein kinase domain containing protein 0.0066 0.0359 0.0935
Echinococcus multilocularis sodium calcium exchanger 0.11 1 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0054 0.0141
Leishmania major protein kinase, putative 0.0066 0.0359 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0054 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0731 0.19
Loa Loa (eye worm) hypothetical protein 0.0281 0.2358 0.2358
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0194 0.1551 1
Loa Loa (eye worm) solute carrier family 8 0.11 1 1
Brugia malayi intermediate filament protein 0.0031 0.0033 0.0087
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0359 0.2318
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0054 0.0054
Schistosoma mansoni lamin 0.0031 0.0033 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0418 0.1086
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0066 0.0359 0.0359
Schistosoma mansoni lamin 0.0031 0.0033 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0106 0.0731 0.0731
Echinococcus multilocularis 0.0066 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0134 0.0994 0.0994
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Leishmania major protein kinase, putative 0.0066 0.0359 0.5
Echinococcus multilocularis lamin dm0 0.0031 0.0033 0.0033
Echinococcus granulosus lamin dm0 0.0031 0.0033 0.0033
Echinococcus multilocularis lamin 0.0031 0.0033 0.0033
Brugia malayi Sodium/calcium exchanger protein 0.044 0.3845 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0066 0.0359 0.5
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0281 0.2358 0.2358
Loa Loa (eye worm) hypothetical protein 0.0031 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0073 0.0418 0.0418
Treponema pallidum hypothetical protein 0.0028 0 0.5
Echinococcus granulosus dual specificity protein kinase clk2 0.0066 0.0359 0.0359
Plasmodium falciparum protein serine/threonine kinase-1 0.0066 0.0359 1
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0281 0.2358 0.2358
Echinococcus multilocularis GPCR, family 2 0.0034 0.0054 0.0054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0054 0.0054
Schistosoma mansoni sodium/calcium exchanger 0.11 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0033 0.0087
Schistosoma mansoni intermediate filament proteins 0.0031 0.0033 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0731 0.19
Loa Loa (eye worm) hypothetical protein 0.044 0.3845 0.3845
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0028 0 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0054 0.0054
Echinococcus granulosus intermediate filament protein 0.0031 0.0033 0.0033
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0066 0.0359 0.5
Echinococcus granulosus hypothetical protein 0.0066 0.0355 0.0355
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0066 0.0359 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0054 0.0141
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0066 0.0359 0.5
Schistosoma mansoni hypothetical protein 0.0073 0.0418 0.0418
Brugia malayi hypothetical protein 0.0134 0.0994 0.2585
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0028 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.0355 0.0355
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0054 0.0054
Plasmodium vivax serine/threonine kinase-1, putative 0.0066 0.0359 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0066 0.0359 0.5
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0028 0 0.5
Onchocerca volvulus 0.0031 0.0033 1
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0033
Echinococcus granulosus GPCR family 2 0.0034 0.0054 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0731 0.0731
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0033 0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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