Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0221 | 0.2585 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0052 | 0.0479 | 0.1769 |
Brugia malayi | hypothetical protein | 0.0785 | 0.9617 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0221 | 0.2585 | 1 |
Onchocerca volvulus | 0.0785 | 0.9617 | 0.5 | |
Brugia malayi | Flap endonuclease-1 | 0.0052 | 0.0479 | 0.0498 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0052 | 0.0479 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0453 | 0.0472 |
Schistosoma mansoni | flap endonuclease-1 | 0.0047 | 0.0416 | 0.1525 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0366 | 0.4389 | 0.4564 |
Schistosoma mansoni | smad | 0.0025 | 0.0139 | 0.0441 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0026 | 0.0027 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0139 | 0.0144 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0139 | 0.0441 |
Entamoeba histolytica | hypothetical protein | 0.0221 | 0.2585 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0139 | 0.0144 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0139 | 0.0441 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0052 | 0.0479 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0139 | 0.0441 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0256 | 0.0897 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0139 | 0.0144 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0052 | 0.0479 | 0.0498 |
Plasmodium falciparum | flap endonuclease 1 | 0.0052 | 0.0479 | 0.5 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0052 | 0.0479 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0139 | 0.0441 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0026 | 0.0027 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0256 | 0.0266 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0139 | 0.0441 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0139 | 0.0441 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0052 | 0.0479 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0221 | 0.2585 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0052 | 0.0479 | 0.5 |
Brugia malayi | Smad1 | 0.0025 | 0.0139 | 0.0144 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0139 | 0.0113 |
Brugia malayi | MH2 domain containing protein | 0.0366 | 0.4389 | 0.4564 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0026 | 0.0027 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0221 | 0.2585 | 0.2566 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0139 | 0.0441 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0366 | 0.4389 | 0.4564 |
Loa Loa (eye worm) | hypothetical protein | 0.0785 | 0.9617 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0052 | 0.0479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0453 | 0.0472 |
Echinococcus granulosus | smad | 0.0025 | 0.0139 | 0.0441 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0139 | 0.0113 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0052 | 0.0479 | 0.0454 |
Brugia malayi | hypothetical protein | 0.0221 | 0.2585 | 0.2688 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0139 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0221 | 0.2585 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0139 | 0.0144 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0453 | 0.0472 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0139 | 0.0113 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0139 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0026 | 0.0027 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0453 | 0.0472 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0221 | 0.2585 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0221 | 0.2585 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0052 | 0.0479 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0139 | 0.0144 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0139 | 0.0441 |
Echinococcus multilocularis | smad | 0.0025 | 0.0139 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0256 | 0.0266 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.