Detailed information for compound 1177199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 632.48 | Formula: C28H24O17
  • H donors: 7 H acceptors: 12 LogP: -0.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(c4c3[C@H]([C@@H](C(=O)O[C@H]2[C@@H]([C@H]1O)O)CC(=O)O)C(=O)O4)O)/C=C/c1ccc(c(c1)O)O
  • InChi: 1S/C28H24O17/c29-12-3-1-9(5-13(12)30)2-4-17(34)43-28-22(37)21(36)23-15(42-28)8-41-25(38)10-6-14(31)20(35)24-18(10)19(27(40)45-24)11(7-16(32)33)26(39)44-23/h1-6,11,15,19,21-23,28-31,35-37H,7-8H2,(H,32,33)/b4-2+/t11-,15+,19-,21+,22+,23+,28-/m0/s1
  • InChiKey: ZOLLYZCOBHDSOG-QUKFQQCQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0523 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0236 0.2151
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0079
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3622 0.3595
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Onchocerca volvulus 0.0015 0.0042 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.2017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0958 0.2671
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0399 0.0548
Loa Loa (eye worm) hypothetical protein 0.0025 0.0293 0.1375
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0079
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0236 0.0627
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3622 0.3595
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0941 0.4312
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.055 0.5644
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0454 0.1973
Brugia malayi hypothetical protein 0.0019 0.0152 0.0526
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0429 0.1855
Plasmodium vivax hexose transporter 0.0103 0.2128 0.2094
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0236 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Leishmania major glucose transporter, lmgt3 0.0032 0.0454 0.4575
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0444 0.4469
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.1877
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0079
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0941 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0445 0.0404
Brugia malayi hypothetical protein 0.003 0.0399 0.1712
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0243 0.2229
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0243 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0958 0.2671
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0444 0.1216
Schistosoma mansoni inositol monophosphatase 0.0039 0.0619 0.1712
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0958 0.2671
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0454 0.4575
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0445 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.078
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1216
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0429 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2128 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0243 0.0961
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0958 0.2671
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0619 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3622 0.5495
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.055 0.5644
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0236 0.3353
Loa Loa (eye worm) sugar transporter 0.0103 0.2128 1
Onchocerca volvulus 0.0015 0.0042 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Trypanosoma brucei glucose transporter 1E 0.0032 0.0454 0.4575
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0454 0.1973
Schistosoma mansoni inositol monophosphatase 0.0039 0.0619 0.1712
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus granulosus geminin 0.0164 0.3548 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.007 0.0306
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0429 0.1855
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0079
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0176 0.0641
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0399 0.0359
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0399 0.3972
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0243 0.0308
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0454 0.4575
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0444 0.2088
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2128 0.3201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0042 0.0079
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0236 0.0627
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2128 0.598
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0619 0.2767
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0243 0.0646
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Schistosoma mansoni sugar transporter 0.0015 0.0042 0.0079
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 0.2471
Echinococcus granulosus General substrate transporter 0.0089 0.1787 0.5015
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0243 0.2255
Toxoplasma gondii protein kinase, putative 0.0292 0.6557 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0243 0.0201
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.055 0.0779
Echinococcus granulosus dna polymerase kappa 0.0023 0.0236 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.007 0.0306
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0445 0.0617
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0444 0.1927
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.2017
Brugia malayi Inositol-1 0.0039 0.0619 0.2767
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0236 0.4024
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0619 0.0886
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0236 0.0627
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0429 0.1174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0619 0.6417
Leishmania major DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Echinococcus multilocularis General substrate transporter 0.0089 0.1787 0.5015
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0445 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0236 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0042 0.0079
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0236 0.0928
Plasmodium falciparum hexose transporter 0.0103 0.2128 0.2094
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 0.5434
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0243 0.5182
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0454 0.4575
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0243 0.3474
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0236 0.2151
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0444 0.1927
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0236 0.0928
Schistosoma mansoni sugar transporter 0.0015 0.0042 0.0079
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.055 0.051
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0445 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0429 0.5041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0399 0.0359
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0619 0.6417
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0444 0.1216
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.055 0.5644
Brugia malayi Sugar transporter family protein 0.0103 0.2128 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.055 0.5644
Onchocerca volvulus 0.0015 0.0042 0.5
Schistosoma mansoni glucose transporter 0.0015 0.0042 0.0079
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0399 0.3972
Trypanosoma cruzi hexose transporter 0.0032 0.0454 0.4575
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0523 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0399 0.3972
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Schistosoma mansoni glucose transport protein 0.0103 0.2128 0.598
Echinococcus multilocularis geminin 0.0164 0.3548 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0958 0.2671
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0573 0.5899
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0236 0.0627
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0958 0.4393
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0619 1
Plasmodium falciparum protein kinase 7 0.0292 0.6557 0.6542
Schistosoma mansoni hypothetical protein 0.0164 0.3548 1
Echinococcus multilocularis dna polymerase eta 0.0053 0.0941 0.2624
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0619 1
Entamoeba histolytica hypothetical protein 0.0023 0.0243 0.0182
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0243 0.2229
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0573 0.0814
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0454 0.1973
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0958 0.2671
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0429 0.1174
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0042 0.0079
Schistosoma mansoni sugar transporter 0.0015 0.0042 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0236 0.2151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0429 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0243 0.3474
Onchocerca volvulus 0.0015 0.0042 0.5
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0243 0.0201
Schistosoma mansoni DNA polymerase eta 0.0053 0.0941 0.2624
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 0.5434
Schistosoma mansoni glucose transport protein 0.0103 0.2128 0.598
Plasmodium falciparum proline--tRNA ligase 0.0036 0.055 0.051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0444 0.2088
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0444 0.2088
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0454 0.1973
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1216
Brugia malayi Cam kinase protein 1 0.0032 0.0444 0.1927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0958 0.2671
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0619 0.6417
Onchocerca volvulus Putative transporter 0.0015 0.0042 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Leishmania major DNA polymerase eta, putative 0.0053 0.0941 1
Schistosoma mansoni hypothetical protein 0.0164 0.3548 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0454 0.1973
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0619 0.2767
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0398 0.1086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Schistosoma mansoni hypothetical protein 0.0103 0.2128 0.598
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0236 0.3353
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0079
Onchocerca volvulus 0.0015 0.0042 0.5
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0454 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0454 0.4575
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0236 0.1108
Trypanosoma brucei unspecified product 0.0023 0.0236 0.2151
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0454 0.4575
Onchocerca volvulus 0.0015 0.0042 0.5
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0445 0.0404
Leishmania major hypothetical protein, conserved 0.003 0.0399 0.3972
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0243 0.0646
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0619 0.6417
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0243 0.0646
Loa Loa (eye worm) inositol-1 0.0039 0.0619 0.2911
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0445 0.0617
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0941 1
Schistosoma mansoni glucose transport protein 0.0103 0.2128 0.598
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0042 0.0079
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0243 0.0961
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0619 0.1712
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0619 0.1712
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0445 0.0404
Schistosoma mansoni sugar transporter 0.0015 0.0042 0.0079
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0079
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0236 0.4024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Leishmania major glucose transporter, lmgt2 0.0032 0.0454 0.4575
Leishmania major protein kinase, putative 0.0032 0.0444 0.4469
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.007 0.0306
Echinococcus granulosus dna polymerase eta 0.0053 0.0941 0.2624
Onchocerca volvulus 0.0015 0.0042 0.5
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0079
Onchocerca volvulus 0.0015 0.0042 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0243 0.0646
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0454 0.4575
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0958 0.4504
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0619 0.2767
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.055 0.5644
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0236 0.0928
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0023 0.0243 0.1141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Trypanosoma brucei unspecified product 0.0016 0.007 0.0306
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0429 0.7404
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0429 0.1174
Trypanosoma brucei glucose transporter 2A 0.0032 0.0454 0.4575
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0398 0.1086
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0042 0.0079
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2128 0.598
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0236 0.2151
Loa Loa (eye worm) hypothetical protein 0.0053 0.0941 0.4425
Leishmania major DNA polymerase eta, putative 0.0037 0.0573 0.5899
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0199
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0399 0.0359
Trypanosoma brucei glucose transporter, putative 0.0032 0.0454 0.4575
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0199
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 0.2471
Giardia lamblia DINP protein human, muc B family 0.0023 0.0236 0.5001
Leishmania major glucose transporter, lmgt1 0.0032 0.0454 0.4575
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1216
Onchocerca volvulus 0.0015 0.0042 0.5
Trypanosoma brucei unspecified product 0.0016 0.007 0.0306
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1216
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0445 0.0404
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0429 0.1174
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0445 0.0617
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0454 0.4575
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0243 0.2229
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0454 0.1973

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 48.42 uM Cytotoxicity against human HepG2 cells ChEMBL. 18302336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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