Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0642 | 0.0916 | 0.0916 |
Echinococcus granulosus | choline O acetyltransferase | 0.0565 | 0.0797 | 0.1454 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2977 | 0.454 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0565 | 0.0797 | 0.1454 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0565 | 0.0797 | 0.0797 |
Onchocerca volvulus | 0.0565 | 0.0797 | 0.5 | |
Onchocerca volvulus | 0.0565 | 0.0797 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0642 | 0.0916 | 0.0319 |
Brugia malayi | Choline O-acetyltransferase | 0.0565 | 0.0797 | 0.0797 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0642 | 0.0916 | 0.0319 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2977 | 0.454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.016 | 0.016 |
Schistosoma mansoni | choline o-acyltransferase | 0.0565 | 0.0797 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0565 | 0.0797 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0565 | 0.0797 | 0.0797 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2977 | 0.454 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0642 | 0.0916 | 0.1726 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2977 | 0.454 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2977 | 0.454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.0797 | 0.0797 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0642 | 0.0916 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0642 | 0.0916 | 0.1726 |
Onchocerca volvulus | 0.0565 | 0.0797 | 0.5 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0642 | 0.0916 | 0.0916 |
Brugia malayi | Choline O-acetyltransferase | 0.0565 | 0.0797 | 0.0797 |
Brugia malayi | Muscleblind-like protein | 0.0155 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.016 | 0.016 |
Onchocerca volvulus | 0.0565 | 0.0797 | 0.5 | |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0565 | 0.0797 | 0.0797 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.