Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0031 | 0.1575 | 0.4936 |
Schistosoma mansoni | phd/f-box containing protein | 0.0031 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | ThiF family protein | 0.0032 | 0.1589 | 0.1589 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.319 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.2117 | 0.2117 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0032 | 0.1589 | 0.751 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0031 | 0.1575 | 0.1575 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0048 | 0.319 | 0.319 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0031 | 0.1575 | 0.7439 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0032 | 0.1589 | 0.751 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0031 | 0.1575 | 0.1575 |
Brugia malayi | ThiF family protein | 0.0032 | 0.1589 | 0.1589 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0031 | 0.1575 | 0.1575 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0044 | 0.276 | 0.276 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.2117 | 0.2117 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.2117 | 0.2117 |
Echinococcus multilocularis | SUMO activating enzyme subunit 2 | 0.0032 | 0.1589 | 0.1589 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1575 | 0.1575 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0048 | 0.319 | 1 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0048 | 0.319 | 1 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0048 | 0.319 | 0.319 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0031 | 0.1575 | 0.4936 |
Brugia malayi | jmjC domain containing protein | 0.0031 | 0.1575 | 0.1575 |
Schistosoma mansoni | ubiquitin-activating enzyme E1b | 0.0032 | 0.1589 | 0.1589 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1575 | 0.1575 |
Brugia malayi | jmjC domain containing protein | 0.0031 | 0.1575 | 0.1575 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0031 | 0.1575 | 0.7439 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0031 | 0.1575 | 0.1575 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.2117 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.2117 | 0.5 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0048 | 0.319 | 0.319 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0031 | 0.1575 | 0.1575 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.2117 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.1739 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.2117 | 0.5 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0027 | 0.116 | 0.5479 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.2117 | 0.2117 |
Schistosoma mansoni | protein phosphatase 2C | 0.0031 | 0.1575 | 0.1575 |
Echinococcus multilocularis | phd:f box containing protein | 0.0031 | 0.1575 | 0.1575 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0031 | 0.1575 | 0.4936 |
Leishmania major | ubiquitin-activating enzyme-like protein | 0.0032 | 0.1589 | 0.751 |
Brugia malayi | ThiF family protein | 0.0048 | 0.319 | 0.319 |
Toxoplasma gondii | ThiF family protein | 0.0032 | 0.1589 | 0.4983 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0031 | 0.1575 | 0.1575 |
Brugia malayi | jmjC domain containing protein | 0.0031 | 0.1575 | 0.1575 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.2117 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.2117 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.1739 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1575 | 0.1575 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0031 | 0.1575 | 0.1575 |
Brugia malayi | Inositol-1 | 0.0037 | 0.2117 | 0.2117 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0031 | 0.1575 | 0.1575 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.2117 | 1 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0031 | 0.1575 | 0.1575 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.1575 | 0.7439 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.2117 | 1 |
Echinococcus granulosus | phd:f box containing protein | 0.0031 | 0.1575 | 0.1575 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.2117 | 0.6636 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0031 | 0.1575 | 0.1575 |
Plasmodium vivax | JmjC domain containing protein | 0.0031 | 0.1575 | 0.4936 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0031 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0031 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.319 | 0.319 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.2117 | 0.2117 |
Schistosoma mansoni | jumonji domain containing protein | 0.0031 | 0.1575 | 0.1575 |
Plasmodium falciparum | SUMO-activating enzyme subunit 2 | 0.0032 | 0.1589 | 0.4983 |
Echinococcus granulosus | sumo-activating enzyme subunit 2 | 0.0032 | 0.1589 | 0.1589 |
Brugia malayi | jmjC domain containing protein | 0.0031 | 0.1575 | 0.1575 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.2117 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.2117 | 0.5 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0031 | 0.1575 | 0.7439 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0031 | 0.1575 | 0.1575 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0032 | 0.1589 | 0.4983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to human GST-SOD1 expressed in Escherichia coli Rosetta at 100 uM in presence of human plasma by reverse phase HPLC analysis | ChEMBL. | 20232802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.