Detailed information for compound 1197067

Basic information

Technical information
  • TDR Targets ID: 1197067
  • Name: (3S)-1,3-di(phenyl)-3-piperidin-1-ylpropan-1- one
  • MW: 293.403 | Formula: C20H23NO
  • H donors: 0 H acceptors: 1 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)C[C@@H](c1ccccc1)N1CCCCC1
  • InChi: 1S/C20H23NO/c22-20(18-12-6-2-7-13-18)16-19(17-10-4-1-5-11-17)21-14-8-3-9-15-21/h1-2,4-7,10-13,19H,3,8-9,14-16H2/t19-/m0/s1
  • InChiKey: CVVZGKZBSZURJO-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-1,3-di(phenyl)-3-(1-piperidyl)propan-1-one
  • (3S)-1,3-di(phenyl)-3-piperidino-propan-1-one
  • (3S)-1,3-di(phenyl)-3-piperidin-1-yl-propan-1-one
  • NSC-35446
  • NCIStruc2_000579
  • NCI35446
  • NCIStruc1_000338
  • NCGC00013406

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase Src42A 0.0179 0.9953 0.9953
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0947 0.0951
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Srms 0.0179 0.9953 0.9953
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis NCK adaptor protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Guanylyl cyclase protein 23 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Brugia malayi SRC-1 0.0179 0.9953 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0179 0.9953 0.9953
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0107 0.3811 0.3829
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0947 0.0947
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0073 0.0994 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0179 0.9953 1
Leishmania major protein kinase, putative 0.0073 0.0947 0.9527
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Brugia malayi cytokine inducible SH2-containing protein 5 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0179 0.9953 0.9953
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0947 0.0951
Schistosoma mansoni hypothetical protein 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0994 0.0998
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Plasmodium vivax protein kinase, putative 0.0073 0.0947 0.5
Brugia malayi integrin-linked kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis SH2 motif 0.0107 0.3811 0.3829
Toxoplasma gondii STE kinase 0.0073 0.0947 0.9527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.3811 0.3829
Trypanosoma brucei Flagellum attachment zone protein 20 0.0073 0.0947 0.9527
Schistosoma mansoni protein tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis activated cdc42 kinase 1 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0947 0.0947
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.0947 0.0951
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0107 0.3811 0.3811
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0073 0.0947 0.0947
Loa Loa (eye worm) SRC-1 0.0179 0.9953 1
Brugia malayi SH2 domain containing protein 0.0179 0.9953 1
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0107 0.3858 0.3233
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus growth factor receptor bound protein 2 0.0107 0.3811 0.3811
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus suppressor of cytokine signaling 6 0.0107 0.3811 0.3811
Echinococcus multilocularis protein kinase 0.0073 0.0947 0.0951
Toxoplasma gondii protein kinase domain-containing protein 0.0073 0.0947 0.9527
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Onchocerca volvulus 0.0107 0.3811 0.3181
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0179 0.9953 0.9953
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0994 0.0998
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Echinococcus multilocularis tyrosine protein kinase Blk 0.0179 0.9953 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0947 0.0951
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Brugia malayi ephrin receptor 1 precursor 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus insulin receptor 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0107 0.3811 0.3829
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0073 0.0947 0.0947
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0073 0.0947 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Leishmania major protein kinase, putative 0.0073 0.0994 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0073 0.0947 0.0951
Schistosoma mansoni nck2/grb4 0.0107 0.3811 0.3829
Trichomonas vaginalis protein tyrosine kinase, putative 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0073 0.0947 0.0947
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Raf kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0107 0.3811 0.3829
Loa Loa (eye worm) SH2 domain-containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine kinase 0.0073 0.0947 0.0947
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tensin 0.0107 0.3811 0.3829
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0073 0.0947 0.0947
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0947 0.9527
Trichomonas vaginalis protein kinase atn1, putative 0.0073 0.0947 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Echinococcus multilocularis SH2 domain containing protein 7 0.0107 0.3811 0.3829
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0947 0.0951
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) SH2 domain-containing protein 0.0107 0.3811 0.3829
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0179 0.9953 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0073 0.0947 0.9527
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Trypanosoma cruzi protein kinase, putative 0.0073 0.0947 0.9527
Trypanosoma brucei Pseudokinase, putative 0.0073 0.0947 0.9527
Echinococcus granulosus NCK adaptor protein 0.0107 0.3811 0.3811
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis SH2 motif 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0073 0.0947 0.0951
Brugia malayi hypothetical protein 0.0179 0.9953 1
Echinococcus granulosus tyrosine protein kinase 0.0073 0.0947 0.0947
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) STAT protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Giardia lamblia Protein 21.1 0.0073 0.0947 1
Echinococcus granulosus N chimaerin 0.0107 0.3811 0.3811
Brugia malayi hypothetical protein 0.0107 0.3811 0.3829
Echinococcus multilocularis SHC transforming protein 3 0.0107 0.3811 0.3829
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TK family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Schistosoma mansoni shc transforming protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine kinase 0.0179 0.9953 0.9953
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0107 0.3811 0.3829
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0947 0.0947
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0947 0.0951
Schistosoma mansoni hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus c src tyrosine kinase 0.0179 0.9953 0.9953
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis N chimaerin 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0179 0.9953 1
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0107 0.3811 0.3811
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni ephrin receptor 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/ABL protein kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0994 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0107 0.3811 0.3829
Echinococcus multilocularis protein KINase family member (kin 25) 0.0073 0.0947 0.0951
Echinococcus granulosus ephrin type A receptor 4 A 0.0073 0.0947 0.0947
Schistosoma mansoni serine/threonine RGC 0.0073 0.0947 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Schistosoma mansoni tensin 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/Met protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis STE family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase ABL1 0.0179 0.9953 0.9953
Echinococcus granulosus integrin linked protein kinase 0.0073 0.0947 0.0947
Giardia lamblia Kinase, NEK 0.0073 0.0947 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.3811 0.3829
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Entamoeba histolytica protein kinase, putative 0.0107 0.3858 0.3233
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus SHC transforming protein 3 0.0107 0.3811 0.3811
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0073 0.0947 0.0947
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0179 0.9953 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi RhoGAP domain containing protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0994 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Onchocerca volvulus 0.0179 0.9953 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tensin 0.0107 0.3811 0.3829
Echinococcus granulosus SH2 domain containing protein 7 0.0107 0.3811 0.3811
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0947 0.9527
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni signal transduction protein lnk-related 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Schistosoma mansoni SH2A 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Src64B 0.0179 0.9953 0.9953
Brugia malayi Tyrosine-protein kinase PR2 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0107 0.3811 0.3829
Onchocerca volvulus 0.0179 0.9953 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0179 0.9953 1
Giardia lamblia Kinase, NEK 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0073 0.0947 0.0951
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0073 0.0994 0.0994
Loa Loa (eye worm) serine/threonine protein kinase 0.0073 0.0947 0.0951
Trypanosoma brucei protein kinase, putative 0.0073 0.0994 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus kinase suppressor of Ras 1 0.0073 0.0947 0.0947
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Brugia malayi hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis integrin linked protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis growth factor receptor bound protein 2 0.0107 0.3811 0.3829
Echinococcus granulosus protein kinase 0.0073 0.0947 0.0947
Schistosoma mansoni suppressor of cytokine signaling 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK protein kinase 0.0179 0.9953 1
Schistosoma mansoni tensin 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis insulin receptor 0.0073 0.0947 0.0951
Echinococcus granulosus expressed conserved protein 0.0107 0.3811 0.3811
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni adapter molecule crk 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0179 0.9953 0.9953
Schistosoma mansoni protein kinase 0.0073 0.0994 0.0998
Leishmania major hypothetical protein, conserved 0.0073 0.0947 0.9527
Loa Loa (eye worm) TK/DDR protein kinase 0.0073 0.0947 0.0951
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0073 0.0947 0.0951
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0947
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis activin receptor type 0.0073 0.0994 0.0998
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3811
Loa Loa (eye worm) TK/FAK protein kinase 0.0073 0.0947 0.0951
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0107 0.3811 0.3181
Echinococcus granulosus tyrosine protein kinase Blk 0.0179 0.9953 0.9953
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.0947 0.0947
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0179 0.9953 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.0947 0.0951
Schistosoma mansoni hypothetical protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tensin 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus multilocularis heat shock protein 70 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0947 0.5
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus natriuretic peptide receptor 1 0.0073 0.0947 0.0947
Onchocerca volvulus 0.0179 0.9953 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/RYK protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni tensin-related 0.0107 0.3811 0.3829
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0947 0.0947
Brugia malayi bone morphogenetic protein type 1 receptor 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni suppressor of cytokine signaling 0.0107 0.3811 0.3829
Echinococcus granulosus SH2 motif 0.0107 0.3811 0.3811
Echinococcus granulosus tensin 0.0107 0.3811 0.3811
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0073 0.0947 0.0947
Brugia malayi Sex muscle abnormal protein 5 0.0107 0.3811 0.3829
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0073 0.0994 0.0998
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Giardia lamblia Kinase 0.0073 0.0947 1
Schistosoma mansoni ephrin receptor 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0947 0.0947
Echinococcus multilocularis tyrosine kinase 0.0179 0.9953 1
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni tyrosine protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0073 0.0947 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0179 0.9953 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0107 0.3811 0.3829
Onchocerca volvulus 0.0179 0.9953 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Srms 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0179 0.9953 1
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0947 1
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/ACK protein kinase 0.0073 0.0947 0.0951
Brugia malayi STAT protein, DNA binding domain containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0179 0.9953 1
Schistosoma mansoni tensin-related 0.0107 0.3811 0.3829
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis protein tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus suppressor of cytokine signaling 7 0.0107 0.3811 0.3811
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi C-terminal src kinase protein 1 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Abl 0.0179 0.9953 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Brugia malayi Tensin 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.0947 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0107 0.3811 0.3811
Brugia malayi hypothetical protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0947
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0179 0.9953 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0107 0.3811 0.3811
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0073 0.0947 0.0947
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.0947 0.0947
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine kinase 0.0179 0.9953 0.9953
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0107 0.3811 0.3829
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase shark 0.0179 0.9953 0.9953
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus signal transduction protein lnk realted 0.0107 0.3811 0.3811
Echinococcus multilocularis ephrin type A receptor 4 A 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0107 0.3811 0.3829
Brugia malayi Tyrosine-protein kinase abl-1 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0947 0.5
Echinococcus granulosus hypothetical protein 0.0107 0.3811 0.3811
Schistosoma mansoni GTPase activating protein 0.0107 0.3811 0.3829
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Toxoplasma gondii protein kinase 0.0073 0.0947 0.9527
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis FL cytokine receptor 0.0073 0.0947 0.0951
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis SH2 motif 0.0107 0.3811 0.3829
Brugia malayi SH2 domain containing protein 0.0179 0.9953 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0994 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0179 0.9953 1
Brugia malayi Receptor family ligand binding region containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0073 0.0947 0.0947
Echinococcus granulosus SH2 domain containing adapter protein F 0.0107 0.3811 0.3811
Echinococcus multilocularis transfer RNA-Thr 0.0073 0.0947 0.0951
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3811
Echinococcus granulosus SH2 motif 0.0107 0.3811 0.3811
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.3811 0.3829
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus protein tyrosine kinase 0.0073 0.0947 0.0947
Onchocerca volvulus 0.0107 0.3811 0.3181
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi protein-tyrosine kinase 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0179 0.9953 1
Entamoeba histolytica SH2 domain containing protein 0.0107 0.3811 0.3181
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0994 1
Schistosoma mansoni vav2 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus activin receptor type 0.0073 0.0994 0.0994
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis c src tyrosine kinase 0.0179 0.9953 1
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/EPH protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Plasmodium falciparum protein kinase, putative 0.0073 0.0994 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0179 0.9953 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0947 0.0951
Trypanosoma cruzi protein kinase, putative 0.0073 0.0947 0.9527
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0107 0.3811 0.3829
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0107 0.3811 0.3181
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis protein kinase 0.0073 0.0947 0.0951

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.258925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.511886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.1259 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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