Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0297 | 0.0297 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6792 | 0.6792 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0297 | 0.0297 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0297 | 0.0297 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0297 | 0.0297 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0297 | 0.0297 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.6792 | 0.6693 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0297 | 0.0297 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6792 | 0.6792 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0297 | 0.0297 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0297 | 0.0297 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0297 | 0.0297 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.6792 | 0.6693 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0297 | 0.0297 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0297 | 0.0297 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6792 | 0.6792 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0297 | 0.0297 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6792 | 0.6792 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6792 | 0.6792 |
Onchocerca volvulus | 0.0012 | 0.0297 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6792 | 0.6792 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0297 | 0.0297 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.0297 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0297 | 0.0297 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.0297 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0297 | 0.0297 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.0297 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0297 | 0.0297 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0297 | 0.0297 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6792 | 0.6792 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0297 | 0.0297 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0297 | 0.0297 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0297 | 0.0297 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.