Detailed information for compound 1202511

Basic information

Technical information
  • TDR Targets ID: 1202511
  • Name: 1-[2-(2-fluorophenyl)-3H-imidazol-4-yl]-N-met hyl-N-(phenylmethyl)methanamine
  • MW: 295.354 | Formula: C18H18FN3
  • H donors: 1 H acceptors: 1 LogP: 3.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1c[nH]c(n1)c1ccccc1F)Cc1ccccc1
  • InChi: 1S/C18H18FN3/c1-22(12-14-7-3-2-4-8-14)13-15-11-20-18(21-15)16-9-5-6-10-17(16)19/h2-11H,12-13H2,1H3,(H,20,21)
  • InChiKey: NWACMLQTMIWMLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl-[[2-(2-fluorophenyl)-3H-imidazol-4-yl]methyl]-methyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.01 0.2548 0.5274
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0306 0.0634
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0115 0.0239
Mycobacterium ulcerans hypothetical protein 0.0166 0.4834 1
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.01 0.2548 0.2313
Brugia malayi RNA binding protein 0.0062 0.1228 0.1959
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0306 0.0634
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0306 0.0634
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0115 0.0239
Echinococcus multilocularis lysosomal protective protein 0.01 0.2548 0.5274
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.009 0.2206 0.4566
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1228 0.254
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0489
Echinococcus granulosus tar DNA binding protein 0.0062 0.1228 0.254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2194 0.4541
Brugia malayi beta-lactamase 0.0035 0.0306 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0115 0.0239
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1228 0.254
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1228 0.1959
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.4251 0.4069
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.01 0.2548 0.2313
Brugia malayi Pre-SET motif family protein 0.0207 0.6266 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.4251 0.4069
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.01 0.2548 0.2313
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1228 0.1959
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.4251 0.4069
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.4834 0.6882
Onchocerca volvulus 0.0035 0.0306 0.0422
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1228 0.254
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.6266 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.062 0.0324
Trichomonas vaginalis set domain proteins, putative 0.0236 0.7258 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0115 0.0239
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.01 0.2548 0.4067
Echinococcus granulosus family S10 non peptidase ue S10 family 0.009 0.2206 0.4566
Loa Loa (eye worm) RNA binding protein 0.0062 0.1228 0.1959
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0489
Onchocerca volvulus 0.0035 0.0306 0.0422
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.062 0.0324
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.01 0.2548 0.2313
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0115 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2194 0.4541
Onchocerca volvulus 0.0035 0.0306 0.0422
Onchocerca volvulus 0.0236 0.7258 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2194 0.4541
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1228 0.254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0115 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0184
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1228 0.1959
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0489
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2194 0.3502
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0306 1
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.01 0.2548 0.2313
Brugia malayi beta-lactamase family protein 0.0035 0.0306 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.062 0.0324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2194 0.4541
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0489
Onchocerca volvulus 0.003 0.0115 0.0159
Schistosoma mansoni hypothetical protein 0.0166 0.4832 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0115 0.0239
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0077 0.016
Schistosoma mansoni hypothetical protein 0.0166 0.4832 1
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.01 0.2548 0.2313
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.01 0.2548 0.2313
Loa Loa (eye worm) beta-lactamase 0.0035 0.0306 0.0489
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0306 0.0489
Toxoplasma gondii ABC1 family protein 0.0035 0.0306 0.2616
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.062 0.0324
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0956 0.067
Brugia malayi Pre-SET motif family protein 0.003 0.0115 0.0184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2194 0.4541
Echinococcus multilocularis geminin 0.0166 0.4832 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0306 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0489
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.6886 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2194 0.3502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0306 0.0634
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0306 0.5
Brugia malayi TAR-binding protein 0.0062 0.1228 0.1959
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.01 0.2548 0.2313
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.01 0.2548 0.5274
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0489
Loa Loa (eye worm) hypothetical protein 0.01 0.2548 0.4067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2194 0.4541
Toxoplasma gondii hypothetical protein 0.0051 0.0846 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2194 0.4541
Brugia malayi beta-lactamase family protein 0.0035 0.0306 0.0489
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.01 0.2548 0.3511
Echinococcus granulosus geminin 0.0166 0.4832 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1228 0.254
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1228 0.254
Echinococcus granulosus lysosomal protective protein 0.01 0.2548 0.5274
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0306 0.0489

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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