Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0085 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.8433 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1265 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.1265 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.8433 | 0.8207 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.8433 | 0.8207 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.1265 | 0.5 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0077 | 0.8903 | 0.8744 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.8433 | 0.8433 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.1265 | 0.0159 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.8433 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.202 | 0.0865 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 0.202 | 0.101 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0085 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 0.202 | 0.0865 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.202 | 0.0865 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0085 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.202 | 0.0865 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.202 | 0.101 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.1265 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0085 | 1 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1265 | 0.1265 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0024 | 0.202 | 0.1054 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0077 | 0.8903 | 0.8744 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.202 | 0.101 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.202 | 0.0865 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.8433 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0024 | 0.202 | 0.0865 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0085 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0085 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.8433 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.8433 | 0.8433 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0085 | 1 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0085 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0085 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0085 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.1265 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1265 | 0.1265 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1265 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1265 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.8433 | 0.8207 |
Echinococcus multilocularis | lysosomal protective protein | 0.0085 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1265 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0085 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.8433 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.