Detailed information for compound 1203929

Basic information

Technical information
  • TDR Targets ID: 1203929
  • Name: MLS001010823
  • MW: 456.902 | Formula: C21H17ClN4O4S
  • H donors: 1 H acceptors: 3 LogP: 4.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)n1c(SCC(=O)Nc2noc(c2)C)nc2c(c1=O)cccc2
  • InChi: 1S/C21H17ClN4O4S/c1-12-9-18(25-30-12)24-19(27)11-31-21-23-16-6-4-3-5-14(16)20(28)26(21)13-7-8-17(29-2)15(22)10-13/h3-10H,11H2,1-2H3,(H,24,25,27)
  • InChiKey: GYOWWIOGHVVGOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000352917
  • T5259426
  • ZINC02619992

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.033 0.6849
Schistosoma mansoni glycogen phosphorylase 0.0212 0.3214 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0092 0.1253 0.0878
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0092 0.1253 0.0811
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0044 0.0481 0.3583
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0554 0.1082
Schistosoma mansoni Neurotrimin precursor (hNT) 0.002 0.0091 0.0283
Brugia malayi hypothetical protein 0.002 0.0091 0.0178
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0481 0.094
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0189 0.037
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0576 0.4744
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 0.055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0481 0.094
Loa Loa (eye worm) hypothetical protein 0.0044 0.0481 0.094
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.1005 0.3127
Brugia malayi SWIRM domain containing protein 0.0044 0.0481 0.094
Loa Loa (eye worm) hypothetical protein 0.0032 0.0283 0.0553
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.1005 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0035
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0044 0.0481 0.3583
Loa Loa (eye worm) hypothetical protein 0.019 0.2858 0.5584
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0469 0.146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0475 0.1479
Schistosoma mansoni glycogen phosphorylase 0.0212 0.3214 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0178
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0576 0.0108
Schistosoma mansoni hypothetical protein 0.0043 0.0469 0.146
Echinococcus multilocularis Glycosyl transferase, family 35 0.0212 0.3214 1
Echinococcus granulosus Glycosyl transferase family 35 0.0212 0.3214 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Echinococcus granulosus GPCR family 2 0.0015 0.0011 0.0035
Schistosoma mansoni lamin 0.0026 0.0189 0.0589
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.037
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0044 0.0481 0.1498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0488 0.1519
Schistosoma mansoni tyrosine kinase 0.0015 0.001 0.0031
Echinococcus multilocularis tyrosine kinase 0.0015 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0035
Brugia malayi Receptor family ligand binding region containing protein 0.004 0.0405 0.0792
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.002 0.0091 0.0283
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0488 0.0954
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0475 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0475 0.1479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0371 0.1154
Chlamydia trachomatis glycogen phosphorylase 0.0212 0.3214 1
Schistosoma mansoni amine oxidase 0.0044 0.0481 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0329 0.1024
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0027 0.0199 0.0618
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0475 0.9878
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.1005 0.3127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Echinococcus multilocularis lamin 0.0026 0.0189 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0455
Echinococcus multilocularis GPCR, family 3, C terminal 0.0025 0.0169 0.0524
Giardia lamblia Glycogen phosphorylase 0.0212 0.3214 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0044 0.0481 0.1498
Echinococcus multilocularis Immunoglobulin 0.002 0.0091 0.0283
Entamoeba histolytica glycogen phosphorylase, putative 0.0212 0.3214 1
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0481 0.3583
Schistosoma mansoni intermediate filament proteins 0.0026 0.0189 0.0589
Echinococcus multilocularis lamin dm0 0.0026 0.0189 0.0589
Echinococcus multilocularis 0.0044 0.0481 0.1498
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0178
Schistosoma mansoni hypothetical protein 0.0025 0.0169 0.0524
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0591
Brugia malayi Metabotropic glutamate receptor precursor. 0.0154 0.2276 0.4448
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0044 0.0481 0.3583
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0481 0.1498
Onchocerca volvulus 0.0301 0.4666 0.9794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0454
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.1005 1
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0329 0.1024
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0025 0.0169 0.0329
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 0.1916
Trichomonas vaginalis glycogen phosphorylase, putative 0.0212 0.3214 1
Schistosoma mansoni vesicular amine transporter 0.002 0.0091 0.0283
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0554 0.1082
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0044 0.0481 0.1498
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.033 0.6934
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0481 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0488 0.1519
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.001 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0455
Echinococcus granulosus lamin 0.0026 0.0189 0.0589
Brugia malayi Probable ClpP-like protease 0.0076 0.1005 0.1963
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1005 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0488 0.1519
Echinococcus multilocularis protoporphyrinogen oxidase 0.0044 0.0481 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0224 0.0698
Echinococcus multilocularis glycogen phosphorylase 0.0212 0.3214 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0329 0.1024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0475 0.0929
Brugia malayi Immunoglobulin I-set domain containing protein 0.0328 0.5118 1
Toxoplasma gondii histone lysine-specific demethylase 0.0044 0.0481 0.3583
Echinococcus multilocularis neuroglian 0.0025 0.0175 0.0546
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0189 0.037
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.001 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0188 0.0584
Entamoeba histolytica glycogen phosphorylase, putative 0.0212 0.3214 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.001 0.0031
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.001 0.002
Loa Loa (eye worm) glutamate receptor 0.0061 0.075 0.1465
Echinococcus multilocularis roundabout 2 0.0032 0.0283 0.0881
Entamoeba histolytica glycogenphosphorylase, putative 0.0092 0.1253 0.2857
Onchocerca volvulus Glycogen phosphorylase homolog 0.0212 0.3214 0.6739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0329 0.1024
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0011 0.0022
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0576 0.1792
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0475 0.9878
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0011 0.0022
Brugia malayi carbohydrate phosphorylase 0.0212 0.3214 0.6279
Brugia malayi intermediate filament protein 0.0026 0.0189 0.037
Echinococcus multilocularis GPCR, family 2 0.0015 0.0011 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0576 0.1792
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.004 0.0405 0.0792
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0488 0.1519
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0481 0.3583
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0129 0.1868 0.5813
Loa Loa (eye worm) hypothetical protein 0.0049 0.0554 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0475 0.1479
Trichomonas vaginalis glycogen phosphorylase, putative 0.0212 0.3214 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0129 0.1868 0.5813
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 0.5
Brugia malayi hypothetical protein 0.0043 0.0469 0.0917
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.004 0.0405 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0183 0.057
Echinococcus granulosus defective proboscis extension response 0.002 0.0091 0.0283
Plasmodium falciparum protoporphyrinogen oxidase 0.0044 0.0481 0.3583
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 0.055
Brugia malayi metabotropic glutamate receptor type 2 0.0075 0.0987 0.1928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0455
Onchocerca volvulus 0.0026 0.0189 0.0377
Echinococcus granulosus tyrosine kinase 0.0015 0.001 0.0031
Echinococcus multilocularis glycogen phosphorylase 0.0212 0.3214 1
Echinococcus granulosus twitchin 0.0025 0.0175 0.0546
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1005 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0178
Leishmania major UDP-galactopyranose mutase 0.0044 0.0481 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0035
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0057 0.1204
Onchocerca volvulus 0.0026 0.0189 0.0377
Echinococcus granulosus GPCR family 3 C terminal 0.0025 0.0169 0.0524
Schistosoma mansoni cell adhesion molecule 0.0027 0.0199 0.0618
Schistosoma mansoni nephrin 0.0025 0.0175 0.0546
Loa Loa (eye worm) hypothetical protein 0.0044 0.0481 0.094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0199 0.0388
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0475 0.0929
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 0.1916
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0481 0.3583
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0488 0.1519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.024 0.0747
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0044 0.0481 0.3583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0488 0.1519
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0469 0.146
Echinococcus multilocularis basement membrane specific heparan sulfate 0.002 0.0091 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0455
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0554 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0146 0.0454
Schistosoma mansoni amine oxidase 0.0044 0.0481 0.1498
Onchocerca volvulus Poor gastrulation protein homolog 0.0025 0.0169 0.0333
Schistosoma mansoni glycogen phosphorylase 0.0092 0.1253 0.39
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.1005 0.3127
Loa Loa (eye worm) hypothetical protein 0.0076 0.1005 0.1963
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0175 0.2621 0.8156
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.001 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0488 0.0954
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0475 0.1479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0188 0.0584
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.014 0.204 0.3985
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0098 0.207
Echinococcus multilocularis Immunoglobulin 0.002 0.0091 0.0283
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.001 0.002
Echinococcus granulosus Immunoglobulin 0.002 0.0091 0.0283
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0475 0.9878
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0481 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0475 0.1479
Schistosoma mansoni protein kinase 0.0015 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0035
Brugia malayi amine oxidase, flavin-containing family protein 0.0044 0.0481 0.094
Schistosoma mansoni metabotropic glutamate receptor 0.0129 0.1868 0.5813
Loa Loa (eye worm) hypothetical protein 0.0044 0.0481 0.094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0011 0.0022
Schistosoma mansoni metabotropic glutamate receptor 0.0075 0.0987 0.307
Brugia malayi hypothetical protein 0.0044 0.0481 0.094
Onchocerca volvulus 0.0044 0.0481 0.0991
Echinococcus granulosus intermediate filament protein 0.0026 0.0189 0.0589
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0178
Entamoeba histolytica glycogen phosphorylase, putative 0.0092 0.1253 0.2857
Echinococcus granulosus lamin dm0 0.0026 0.0189 0.0589
Loa Loa (eye worm) glutamate receptor 0.0154 0.2276 0.4448
Echinococcus granulosus roundabout 2 0.0032 0.0283 0.0881
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0469 0.146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0183 0.057
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0576 0.0108
Echinococcus granulosus neuroglian 0.0025 0.0175 0.0546
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0475 0.0023
Echinococcus granulosus glycogen phosphorylase 0.0212 0.3214 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0481 0.1498
Loa Loa (eye worm) hypothetical protein 0.0032 0.0283 0.0553
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0025 0.0169 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Schistosoma mansoni hypothetical protein 0.0033 0.0303 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0475 0.1479
Onchocerca volvulus Tyrosine kinase homolog 0.0307 0.4764 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0329 0.1024
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0328 0.5118 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.033 0.6849
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0189 0.037
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0292 0.1264
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.001 0.002
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0044 0.0481 0.3583
Echinococcus granulosus glycogen phosphorylase 0.0212 0.3214 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0188 0.0584
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0405 0.0792
Entamoeba histolytica glycogen phosphorylase, putative 0.0092 0.1253 0.2857
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0475 0.0023
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1005 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.019 0.2858 0.8893
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0303 0.0591
Schistosoma mansoni lamin 0.0026 0.0189 0.0589
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0178
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0475 0.9878
Echinococcus multilocularis musashi 0.0026 0.0189 0.0589
Loa Loa (eye worm) glycogen phosphorylase 0.0212 0.3214 0.6279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0091 0.0178
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0583 0.9279 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.019 0.2858 0.8893
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0329
Loa Loa (eye worm) hypothetical protein 0.0044 0.0481 0.094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0292 0.0909
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0628 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0488 0.1519
Brugia malayi Fibronectin type III domain containing protein 0.002 0.0091 0.0178
Schistosoma mansoni tyrosine kinase 0.0015 0.001 0.0031

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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