Detailed information for compound 1234647

Basic information

Technical information
  • TDR Targets ID: 1234647
  • Name: methyl 2-[[5-(3,4-dimethoxyphenyl)-1,3,4-oxad iazol-2-yl]sulfanyl]acetate
  • MW: 310.326 | Formula: C13H14N2O5S
  • H donors: 0 H acceptors: 3 LogP: 2.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CSc1nnc(o1)c1ccc(c(c1)OC)OC
  • InChi: 1S/C13H14N2O5S/c1-17-9-5-4-8(6-10(9)18-2)12-14-15-13(20-12)21-7-11(16)19-3/h4-6H,7H2,1-3H3
  • InChiKey: AWWNFEAQPIIGHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid methyl ester
  • methyl 2-[[5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoate
  • ASN 03575094
  • MLS000692885
  • SMR000285581
  • ZINC00421890

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0163 0.3906 0.5708
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.6843 0.6843
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0049 0.0811 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0427 0.1338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0798 0.0798
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0182 0.4435 0.4435
Leishmania major developmentally regulated phosphoprotein-like protein 0.0116 0.2633 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0749 0.3166
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0098 0.2152 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.2547 0.3723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0202 0.05
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0221 0.0497
Entamoeba histolytica hypothetical protein 0.0079 0.1623 0.6222
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0221 0.0497
Echinococcus multilocularis protein dispatched 1 0.0055 0.0984 0.0984
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0045 0.0709 0.2492
Loa Loa (eye worm) hypothetical protein 0.0059 0.1094 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0202 0.05
Schistosoma mansoni survival motor neuron protein 0.0055 0.0984 0.2219
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.3862 0.3862
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1117 0.1632
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.6843 0.6843
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0116 0.2633 0.2633
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0798 0.0798
Onchocerca volvulus 0.0057 0.1022 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0749 0.0749
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1117 0.1632
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0221 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0271 0.0834
Schistosoma mansoni hypothetical protein 0.0041 0.06 0.1352
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0984 0.1438
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1117 0.1632
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0507 0.1757
Schistosoma mansoni pyruvate dehydrogenase 0.011 0.2458 0.5541
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0427 0.1338
Schistosoma mansoni ap endonuclease 0.0023 0.0099 0.0224
Echinococcus multilocularis protein patched 0.0048 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.005
Echinococcus granulosus expressed conserved protein 0.0106 0.2362 0.2362
Entamoeba histolytica hypothetical protein 0.0041 0.0603 0.2057
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.2152 0.8385
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0507 0.1609
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0221 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0099 0.3482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0506 0.1981
Giardia lamblia GTOR 0.0047 0.0749 0.9136
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0099 0.5
Schistosoma mansoni pyruvate dehydrogenase 0.0116 0.2633 0.5936
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0221 0.0323
Echinococcus multilocularis tumor protein p63 0.0388 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0507 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0603 0.0603
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0047 0.0759 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0749 0.3166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0749 0.1095
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0029 0.0273 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0264 0.08
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0035 0.0427 0.1293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0116 0.2633 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Schistosoma mansoni hypothetical protein 0.0047 0.0751 0.1693
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0122 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.06 0.0877
Loa Loa (eye worm) hypothetical protein 0.0041 0.06 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0202 0.05
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.1239 0.181
Brugia malayi hypothetical protein 0.0271 0.6843 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.2633 0.3847
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0603 0.0603
Entamoeba histolytica hypothetical protein 0.0041 0.0603 0.2057
Schistosoma mansoni pyruvate dehydrogenase 0.011 0.2458 0.5541
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0749 0.0749
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0221 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0098 0.2152 0.8102
Loa Loa (eye worm) hypothetical protein 0.0065 0.1239 0.181
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0098 0.2152 1
Brugia malayi CHE-14 protein 0.0048 0.0798 0.1166
Schistosoma mansoni hypothetical protein 0.0047 0.0751 0.1693
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0221 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0575 0.2319
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0221 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0093 0.1999 0.7758
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0099 0.0145
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0221 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0271 0.0834
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0035 0.0427 0.1596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0749 0.3166
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0221 0.048
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.2547 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0099 0.0099
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0749 0.2697
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.005
Trypanosoma brucei developmentally regulated phosphoprotein 0.0116 0.2633 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0749 0.2565
Loa Loa (eye worm) hypothetical protein 0.0027 0.0221 0.0323
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0584 0.1914
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0099 0.4388
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0025 0.0166 0.0936
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0798 0.0798
Brugia malayi hypothetical protein 0.0041 0.0603 0.0881
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.005
Echinococcus multilocularis expressed conserved protein 0.0106 0.2362 0.2362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0116 0.2633 0.2633
Entamoeba histolytica hypothetical protein 0.0041 0.0603 0.2057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0271 0.0834
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0506 0.1981
Loa Loa (eye worm) hypothetical protein 0.0057 0.1022 0.1494
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0749 0.2565
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0099 0.0176
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0749 0.2565
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0221 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.134 0.6045
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0034 0.139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0506 0.1981
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0749 0.1095
Loa Loa (eye worm) hypothetical protein 0.0271 0.6843 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0099 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0099 0.5
Mycobacterium ulcerans hypothetical protein 0.0027 0.0221 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0182 0.4435 0.4435
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0221 0.048
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0749 0.2565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0201 0.0496
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0221 0.0323
Loa Loa (eye worm) hypothetical protein 0.0034 0.0396 0.0579
Onchocerca volvulus 0.0055 0.0984 0.9524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0506 0.1981
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0749 0.2655
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0221 1
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.3862 0.3862
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.134 0.6045
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0221 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0034 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0182 0.4435 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0221 0.0323
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0221 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0427 0.1596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0332 0.1133
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.2547 0.2547
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0116 0.2633 0.2633
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0221 0.5
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0749 0.2697
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0749 0.2655
Entamoeba histolytica hypothetical protein 0.0041 0.0603 0.2057
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.2595 0.585
Loa Loa (eye worm) hypothetical protein 0.0048 0.0798 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0506 0.1981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0445 0.1681
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0584 0.2056
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0084 0.1766 0.2581
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0427 0.1447
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.2547 0.2547
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0221 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0427 0.0624
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0079 0.1623 0.6222
Loa Loa (eye worm) hypothetical protein 0.0027 0.0221 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0201 0.0496
Schistosoma mansoni hypothetical protein 0.0055 0.0984 0.2219
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0221 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0798 0.1166
Loa Loa (eye worm) hypothetical protein 0.0113 0.2547 0.3723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0201 0.0496
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0221 0.048
Schistosoma mansoni hypothetical protein 0.0041 0.0603 0.1359
Brugia malayi kinase, mitochondrial precursor 0.0116 0.2633 0.3847
Schistosoma mansoni ap endonuclease 0.0023 0.0099 0.0224
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0749 0.169
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0584 0.1914
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0041 0.0584 0.7345
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0358 0.1258
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0603 0.1359
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.1022 0.2305
Schistosoma mansoni hypothetical protein 0.0047 0.0751 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0202 0.05
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0098 0.2152 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0035 0.0427 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0798 0.3404
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.005
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0098 0.2152 0.8102
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0273 0.04
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0065 0.1239 0.1239
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0427 0.1596
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0099 0.0145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.2152 0.3145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0264 0.08
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0065 0.1239 0.1239
Schistosoma mansoni patched 1 0.0048 0.0798 0.1799
Schistosoma mansoni hypothetical protein 0.0047 0.0751 0.1693
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1117 0.1632
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0445 0.5229

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.