Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroligin | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Brugia malayi | Carboxylesterase family protein | 0.0117 | 0.1119 | 0.1119 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Brugia malayi | Carboxylesterase family protein | 0.0117 | 0.1119 | 0.1119 |
Onchocerca volvulus | 0.0117 | 0.1119 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0117 | 0.1119 | 0.1119 |
Schistosoma mansoni | acetylcholinesterase | 0.0117 | 0.1119 | 0.1119 |
Echinococcus granulosus | carboxylesterase 5A | 0.0695 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0117 | 0.1119 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.1106 | 0.1106 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0695 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0695 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Brugia malayi | Carboxylesterase family protein | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | carboxylesterase | 0.0117 | 0.1119 | 0.1119 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0117 | 0.1119 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0117 | 0.1119 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Echinococcus granulosus | acetylcholinesterase | 0.0695 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0117 | 0.1119 | 0.1119 |
Echinococcus multilocularis | neuroligin | 0.0117 | 0.1119 | 0.1119 |
Onchocerca volvulus | 0.0117 | 0.1119 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0695 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0117 | 0.1119 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0674 | 0.9674 | 0.9674 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0695 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.1106 | 0.1106 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0117 | 0.1119 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Onchocerca volvulus | 0.0117 | 0.1119 | 0.5 | |
Schistosoma mansoni | microtubule-associated protein tau | 0.0674 | 0.9674 | 0.9674 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0117 | 0.1119 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0695 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0117 | 0.1119 | 0.1119 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0674 | 0.9674 | 0.9674 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0117 | 0.1119 | 0.1119 |
Echinococcus granulosus | acetylcholinesterase | 0.0695 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0117 | 0.1119 | 0.1119 |
Onchocerca volvulus | 0.0117 | 0.1119 | 0.5 | |
Onchocerca volvulus | 0.0117 | 0.1119 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0117 | 0.1119 | 0.1119 |
Schistosoma mansoni | gliotactin | 0.0117 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.1106 | 0.1106 |
Echinococcus multilocularis | acetylcholinesterase | 0.0695 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0695 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.