Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0446 | 0.0446 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0446 | 0.0446 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0446 | 0.0446 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.012 | 0.3242 | 0.3242 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0322 | 1 | 1 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.012 | 0.3242 | 0.3242 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0322 | 1 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0446 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0322 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0446 | 0.0446 |
Onchocerca volvulus | 0.0286 | 0.8801 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.7641 | 0.7641 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0322 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0322 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0446 | 0.0446 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0446 | 0.0446 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0446 | 0.0446 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0322 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.012 | 0.3242 | 0.3242 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0446 | 0.0446 |
Leishmania major | 0.0322 | 1 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.7641 | 0.7641 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0446 | 0.0446 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0401 | 0.0401 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0322 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0322 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.8801 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.012 | 0.3242 | 0.3242 |
Toxoplasma gondii | fructose-bisphospatase I | 0.012 | 0.3242 | 0.3242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0053 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.