Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase-related | 0.1116 | 0.4355 | 0.1687 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1517 | 0.5983 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0214 | 0.0697 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1517 | 0.5983 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0074 | 0.0127 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.2507 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1116 | 0.4355 | 0.1687 |
Toxoplasma gondii | hypothetical protein | 0.1116 | 0.4355 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1587 | 0.6268 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1116 | 0.4355 | 0.4282 |
Schistosoma mansoni | carbonic anhydrase | 0.1517 | 0.5983 | 0.4084 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2507 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1116 | 0.4355 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1019 | 0.3963 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1116 | 0.4355 | 0.4282 |
Loa Loa (eye worm) | hypothetical protein | 0.2355 | 0.9383 | 0.8907 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2507 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.2507 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2507 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2507 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1517 | 0.5983 | 0.9545 |
Onchocerca volvulus | 0.0214 | 0.0697 | 1 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.1116 | 0.4355 | 0.1687 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2507 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1587 | 0.6268 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1587 | 0.6268 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2507 | 1 | 1 |
Mycobacterium ulcerans | transferase | 0.0071 | 0.0116 | 0.0185 |
Echinococcus multilocularis | carbonic anhydrase | 0.1116 | 0.4355 | 0.1687 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1517 | 0.5983 | 0.5983 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0815 | 0.3136 | 0.7912 |
Entamoeba histolytica | ankyrin, putative | 0.0074 | 0.0127 | 0.0213 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2507 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.321 | 0.3122 |
Entamoeba histolytica | acetyltransferase, putative | 0.0074 | 0.0127 | 0.0213 |
Echinococcus granulosus | carbonic anhydrase | 0.1116 | 0.4355 | 0.4282 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0949 | 0.3678 | 0.928 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2507 | 1 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0247 | 0.0831 | 0.1219 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0074 | 0.0127 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1116 | 0.4355 | 0.1687 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0074 | 0.0127 | 0.0322 |
Echinococcus multilocularis | carbonic anhydrase | 0.1116 | 0.4355 | 0.1687 |
Schistosoma mansoni | hypothetical protein | 0.1116 | 0.4355 | 0.1687 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2507 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0247 | 0.0831 | 0.2097 |
Schistosoma mansoni | carbonic anhydrase | 0.1116 | 0.4355 | 0.1687 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0355 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 37.6505 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.