Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.2589 | 0.888 | 1 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.2589 | 0.888 | 1 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.2589 | 0.888 | 0.5 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.2589 | 0.888 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.2589 | 0.888 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.2589 | 0.888 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0951 | 0.1013 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0951 | 0.1013 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0951 | 0.1013 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.2822 | 1 | 0.5 |
Loa Loa (eye worm) | twinkle helicase | 0.074 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0951 | 0.1013 | 0.5 |
Chlamydia trachomatis | replicative DNA helicase | 0.2589 | 0.888 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | < 4.3 | Agonist activity at PAR2 receptor in human HT-29 cells assessed as induction of intracellular calcium release | ChEMBL. | 20873792 |
EC50 (functional) | > 50 uM | Agonist activity at PAR2 receptor in human HT-29 cells assessed as induction of intracellular calcium release | ChEMBL. | 20873792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.