TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 443.554 | Formula: C25H34FN3O3
H donors: 2 H acceptors: 2 LogP: 3.02 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CO[C@@H](c1ccc(cc1)F)C[C@@H](C(=O)NO)CCN1CCN(CC1)CCc1ccccc1
InChi: 1S/C25H34FN3O3/c1-32-24(21-7-9-23(26)10-8-21)19-22(25(30)27-31)12-14-29-17-15-28(16-18-29)13-11-20-5-3-2-4-6-20/h2-10,22,24,31H,11-19H2,1H3,(H,27,30)/t22-,24+/m0/s1
InChiKey: JIBIPYGNBCVWPR-LADGPHEKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus anthracis	Anthrax lethal factor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0061	0.0318	0.0318
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0043	0.0177	0.0088
Trichomonas vaginalis	CMGC family protein kinase	0.008	0.0464	0.015
Plasmodium vivax	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.008	0.0464	0.015
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0039	0.0146	0.0057
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0377	0.2754	0.2516
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.008	0.0464	0.015
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Brugia malayi	Protein kinase domain containing protein	0.0516	0.3826	0.3826
Brugia malayi	Protein kinase domain containing protein	0.0505	0.3742	0.3742
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0132	0.0863	0.0563
Echinococcus multilocularis	homeodomain interacting protein kinase 3	0.0198	0.1378	0.1278
Echinococcus granulosus	cyclin dependent kinase 5	0.0061	0.0318	0.0231
Brugia malayi	Homeodomain interacting protein kinase protein 1	0.0198	0.1378	0.1378
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Echinococcus granulosus	tyrosine protein kinase Blk	0.0039	0.0146	0.0057
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.008	0.0464	0.015
Entamoeba histolytica	casein kinase, putative	0.1317	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.1378	0.1278
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.1317	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0043	0.0177	0.0063
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0061	0.0318	0.0017
Schistosoma mansoni	casein kinase II beta subunit	0.0377	0.2754	0.2623
Loa Loa (eye worm)	Csnk2b protein	0.0377	0.2754	0.2754
Trichomonas vaginalis	cyclins, putative	0.0132	0.0863	0.0563
Brugia malayi	protein-tyrosine kinase	0.0039	0.0146	0.0146
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0177	0.0088
Trypanosoma cruzi	cyclin, putative	0.0132	0.0863	0.0563
Echinococcus multilocularis	cyclin B	0.0132	0.0863	0.0757
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0318	0.0318
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0266	0.0266
Giardia lamblia	G2/mitotic-specific cyclin B	0.0132	0.0863	0.0563
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Brugia malayi	SRC-1	0.0043	0.0177	0.0177
Trichomonas vaginalis	cyclin B3, putative	0.0077	0.0446	0.0131
Leishmania major	protein kinase, putative	0.008	0.0464	0.015
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.1317	1	1
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0377	0.2754	0.638
Onchocerca volvulus		0.0516	0.3826	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0061	0.0318	0.0206
Entamoeba histolytica	cyclin, putative	0.0077	0.0446	0.0335
Trichomonas vaginalis	cyclins, putative	0.0132	0.0863	0.0563
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.0464	0.0292
Echinococcus granulosus	cyclins	0.0077	0.0446	0.0359
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.0464	0.0292
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0377	0.2754	0.2528
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0039	0.0146	0.0032
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Echinococcus granulosus	dual specificity protein kinase clk2	0.008	0.0464	0.0377
Plasmodium falciparum	casein kinase II beta chain	0.0377	0.2754	0.2516
Loa Loa (eye worm)	TK protein kinase	0.0039	0.0146	0.0146
Loa Loa (eye worm)	casein kinase II	0.011	0.0698	0.0698
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.008	0.0464	0.0167
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0039	0.0146	0.0032
Trypanosoma brucei	Casein kinase II	0.1317	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0057	0.0288	0.02
Loa Loa (eye worm)	IKK protein kinase	0.0516	0.3826	0.3826
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0276	0.1977	0.1977
Echinococcus granulosus	cyclins	0.0077	0.0446	0.0359
Echinococcus granulosus	cyclins	0.0077	0.0446	0.0359
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.011	0.0698	0.059
Plasmodium falciparum	protein serine/threonine kinase-1	0.008	0.0464	0.015
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0446	0.0131
Trypanosoma cruzi	cyclin 6, putative	0.0132	0.0863	0.0563
Trypanosoma brucei	mitotic cyclin 6	0.0132	0.0863	0.0563
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0199	0.1381	0.1281
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	cyclin A, putative	0.0132	0.0863	0.0563
Echinococcus granulosus	cyclin b3	0.0077	0.0446	0.0359
Echinococcus granulosus	cyclins	0.0077	0.0446	0.0359
Trichomonas vaginalis	cyclin B, putative	0.0132	0.0863	0.0563
Echinococcus multilocularis		0.0065	0.0353	0.0241
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.011	0.0698	0.059
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0177	0.0088
Echinococcus multilocularis	cyclin dependent kinase 1	0.0061	0.0318	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0353	0.0353
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Toxoplasma gondii	ck2 beta subunit	0.0377	0.2754	0.2528
Echinococcus multilocularis	cyclin B3 1	0.0077	0.0446	0.0335
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0061	0.0318	0.0318
Schistosoma mansoni	cyclin B	0.0132	0.0863	0.0698
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0043	0.0177	0.0063
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0377	0.2754	0.2516
Trichomonas vaginalis	cyclins, putative	0.0073	0.041	0.0095
Echinococcus granulosus	tyrosine protein kinase HCK	0.0034	0.0115	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0863	0.0863
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Echinococcus multilocularis	death associated protein kinase 1	0.0899	0.6776	0.6738
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	cyclin B, putative	0.0077	0.0446	0.0131
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	0.0198	0.1378	0.1378
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0043	0.0177	0.0063
Giardia lamblia	Casein kinase II beta chain	0.0377	0.2754	0.2516
Leishmania major	cyclin	0.0132	0.0863	0.0563
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Giardia lamblia	Casein kinase II beta chain	0.011	0.0698	0.0392
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0505	0.3742	0.9716
Schistosoma mansoni	cyclin B3	0.0199	0.1381	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0863	0.0863
Leishmania major	casein kinase II, putative	0.1317	1	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0199	0.1381	0.1381
Trypanosoma cruzi	cyclin, putative	0.0132	0.0863	0.0563
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0043	0.0177	0.0088
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0377	0.2754	0.2516
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0199	0.1381	0.1303
Echinococcus multilocularis	cyclin dependent kinase	0.0061	0.0318	0.0206
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0377	0.2754	0.267
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Brugia malayi	cell division control protein 2 homolog	0.0061	0.0318	0.0318
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0177	0.0088
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0177	0.0063
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.008	0.0464	0.0464
Trypanosoma cruzi	casein kinase II, putative	0.1317	1	1
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0377	0.2754	0.638
Toxoplasma gondii	CMGC kinase, CK2 family	0.1317	1	1
Leishmania major	protein kinase, putative	0.008	0.0464	0.015
Schistosoma mansoni	cyclins	0.0077	0.0446	0.0273
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0318	0.0144
Echinococcus multilocularis	cyclin dependent kinase 5	0.0061	0.0318	0.0206
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Schistosoma mansoni	serine/threonine protein kinase	0.0198	0.1378	0.1222
Giardia lamblia	Cyclin A	0.0077	0.0446	0.0131
Plasmodium falciparum	casein kinase 2, alpha subunit	0.1317	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0036	0.0126	0.0011
Loa Loa (eye worm)	cyclin domain-containing protein	0.0276	0.1977	0.1977
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0505	0.3742	0.3742
Entamoeba histolytica	cyclin family protein	0.0077	0.0446	0.0335
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0132	0.0863	0.0863
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Loa Loa (eye worm)	cyclin domain-containing protein	0.0199	0.1381	0.1381
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Trichomonas vaginalis	cyclin B, putative	0.0132	0.0863	0.0563
Giardia lamblia	Hypothetical protein	0.0077	0.0446	0.0131
Giardia lamblia	Kinase, CMGC CLK	0.008	0.0464	0.015
Brugia malayi	casein kinase II, putaitve	0.011	0.0698	0.0698
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0146	0.0032
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0505	0.3742	0.367
Trichomonas vaginalis	cyclins, putative	0.0077	0.0446	0.0131
Echinococcus multilocularis	casein kinase ii subunit beta	0.0377	0.2754	0.267
Trichomonas vaginalis	cyclin D, putative	0.0077	0.0446	0.0131
Echinococcus granulosus	cyclins	0.0077	0.0446	0.0359
Schistosoma mansoni	protein kinase	0.1317	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0318	0.0144
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0177	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0208	0.0208
Echinococcus granulosus	casein kinase ii subunit alpha	0.1317	1	1
Plasmodium vivax	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Echinococcus multilocularis	dual specificity protein kinase clk2	0.008	0.0464	0.0353
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0177	0.0088
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0036	0.0126	0.0036
Plasmodium falciparum	casein kinase II beta chain	0.0377	0.2754	0.2516
Trichomonas vaginalis	cyclins, putative	0.0132	0.0863	0.0563
Entamoeba histolytica	cell division protein kinase 2, putative	0.0061	0.0318	0.0206
Echinococcus granulosus	cyclin dependent kinase	0.0061	0.0318	0.0231
Plasmodium falciparum	cyclin	0.0077	0.0446	0.0131
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Loa Loa (eye worm)	SRC-1	0.0043	0.0177	0.0177
Schistosoma mansoni	serine/threonine protein kinase	0.0505	0.3742	0.3629
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0043	0.0177	0.0088
Plasmodium vivax	serine/threonine kinase-1, putative	0.008	0.0464	0.015
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Trichomonas vaginalis	cyclin B, putative	0.0132	0.0863	0.0563
Brugia malayi	Protein kinase domain containing protein	0.008	0.0464	0.0464
Trichomonas vaginalis	cyclins, putative	0.0132	0.0863	0.0563
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0061	0.0318	0.0231
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Echinococcus granulosus	homeodomain interacting protein kinase 3	0.0198	0.1378	0.13
Brugia malayi	Csnk2b protein	0.0377	0.2754	0.2754
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0177	0.0063
Echinococcus granulosus	cyclin dependent kinase 1	0.0061	0.0318	0.0231
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0505	0.3742	0.3742
Entamoeba histolytica	cell division protein kinase 2, putative	0.0061	0.0318	0.0206
Echinococcus multilocularis	casein kinase ii subunit alpha	0.1317	1	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0061	0.0318	0.0318
Entamoeba histolytica	cyclin family protein	0.0077	0.0446	0.0335
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0377	0.2754	0.2516
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0132	0.0863	0.0563
Echinococcus granulosus	cyclin B3 1	0.0077	0.0446	0.0359
Trichomonas vaginalis	cyclin B, putative	0.0132	0.0863	0.0563
Echinococcus granulosus	casein kinase ii subunit beta	0.0377	0.2754	0.2688
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.008	0.0464	0.015
Trichomonas vaginalis	casein kinase II beta chain, putative	0.011	0.0698	0.0392
Echinococcus multilocularis	cyclin b3	0.0077	0.0446	0.0335
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0377	0.2754	0.2516
Trichomonas vaginalis	cyclin D, putative	0.0077	0.0446	0.0131
Trichomonas vaginalis	CMGC family protein kinase	0.1317	1	1
Plasmodium vivax	unspecified product	0.1317	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1317	1	1
Entamoeba histolytica	cyclin, putative	0.0132	0.0863	0.0757
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.008	0.0464	0.015
Echinococcus granulosus	cyclin B	0.0132	0.0863	0.078
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0505	0.3742	0.3742
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0505	0.3742	0.3686
Echinococcus granulosus	tyrosine kinase	0.0039	0.0146	0.0057
Echinococcus granulosus	hypothetical protein	0.0065	0.0353	0.0266
Giardia lamblia	Kinase, CMGC CK2	0.1317	1	1
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Loa Loa (eye worm)	TK protein kinase	0.0034	0.0115	0.0115
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0377	0.2754	0.267
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0043	0.0177	0.0063
Echinococcus multilocularis	cyclins	0.0077	0.0446	0.0335
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0132	0.0863	0.0863
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0377	0.2754	0.267
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0043	0.0177	0.0063
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.008	0.0464	0.015
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0177	0.0063

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 118 nM	Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assay	ChEMBL.	20864339

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1270904

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1256218