pI: 8.6812 |
Length (AA): 828 |
MW (Da): 90643 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 400 | 3i6u (A) | 154 | 487 | 24.00 | 0 | 1 | 0.274961 | 1.29 |
5 | 339 | 3i6u (B) | 154 | 496 | 23.00 | 0 | 1 | 0.469289 | 0.31 |
16 | 281 | 3i6u (B) | 165 | 440 | 31.00 | 0.00000014 | 0.99 | 0.383056 | 0.93 |
39 | 401 | 4ylk (A) | 141 | 481 | 36.00 | 0 | 1 | 0.786106 | -0.42 |
39 | 400 | 3kvw (A) | 131 | 463 | 35.00 | 0 | 1 | 0.757898 | -0.35 |
57 | 502 | 5dvr (A) | 47 | 491 | 21.00 | 0 | 1 | 0.403347 | 1.31 |
176 | 292 | 3vut (A) | 209 | 326 | 47.00 | 0.0049 | 0.93 | 0.0791043 | 1.61 |
429 | 623 | 4ke2 (A) | 20 | 195 | 31.00 | 0.13 | 0.23 | 0.234307 | 1.9 |
651 | 736 | 1kwa (A) | 488 | 572 | 18.00 | 0.038 | 0.08 | 0.142565 | -0.25 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129272)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_21245 | Homeodomain interacting protein kinase protein 1 |
Candida albicans | CaO19.147 | similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase |
Candida albicans | CaO19.148 | hypothetical protein |
Candida albicans | CaO19.7787 | similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase |
Candida albicans | CaO19.7788 | hypothetical protein |
Caenorhabditis elegans | CELE_F20B6.8 | Protein HPK-1, isoform C |
Drosophila melanogaster | Dmel_CG17090 | homeodomain interacting protein kinase |
Echinococcus granulosus | EgrG_001067800 | homeodomain interacting protein kinase 3 |
Entamoeba histolytica | EHI_153120 | protein kinase domain containing protein |
Echinococcus multilocularis | EmuJ_001067800 | homeodomain interacting protein kinase 3 |
Homo sapiens | ENSG00000163349 | homeodomain interacting protein kinase 1 |
Homo sapiens | ENSG00000064393 | homeodomain interacting protein kinase 2 |
Homo sapiens | ENSG00000110422 | homeodomain interacting protein kinase 3 |
Loa Loa (eye worm) | LOAG_04459 | CMGC/DYRK/HIPK protein kinase |
Mus musculus | ENSMUSG00000027177 | homeodomain interacting protein kinase 3 |
Mus musculus | ENSMUSG00000061436 | homeodomain interacting protein kinase 2 |
Mus musculus | ensembl-mmu:ENSMUSG00000008730 | homeodomain interacting protein kinase 1 |
Schistosoma japonicum | Sjp_0106630 | ko:K08826 homeodomain interacting protein kinase, putative |
Schistosoma japonicum | Sjp_0013650 | expressed protein |
Schistosoma mansoni | Smp_000720 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.001360.04 | Homeodomain-interacting protein kinase 4 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | homeodomain interacting protein kinase 3 | Compounds | References |
Homo sapiens | homeodomain interacting protein kinase 1 | Compounds | References |
Homo sapiens | homeodomain interacting protein kinase 2 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Mitogen-activated protein kinase 8 | 411 aa | 26.1% | 352 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 27.4% | 241 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 25.1% | 363 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 28.9% | 235 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 30.5% | 236 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 26.4% | 349 aa | Compounds | References |
Zea mays | Casein kinase II alpha | 332 aa | 22.7% | 348 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 23.4% | 368 aa | Compounds | References |
1 literature reference was collected for this gene.