pI: 7.341 |
Length (AA): 245 |
MW (Da): 28365 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
20 | 187 | 1qf8 (A) | 8 | 179 | 40.00 | 0 | 1 | 1.27 | -1.63 |
20 | 214 | 4dgl (A) | 8 | 206 | 36.00 | 0 | 1 | 1.25782 | -0.31 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | gametocyte, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Female Gametocyte. | Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Male Gametocyte. | Lasonder E |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_126846)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G60250 | casein kinase 2 subunit beta-3 |
Arabidopsis thaliana | AT5G47080 | casein kinase 2 subunit beta |
Arabidopsis thaliana | AT4G17640 | casein kinase II beta chain 2 |
Arabidopsis thaliana | AT2G44680 | casein kinase II beta subunit 4 |
Babesia bovis | BBOV_II006230 | protein kinase CK2 regulatory subunit CK2B1 |
Babesia bovis | BBOV_IV008950 | casein kinase II beta 4 subunit, putative |
Brugia malayi | Bm1_48865 | Csnk2b protein |
Candida albicans | CaO19.9650 | Casein kinase II, regulatory (beta) subunit |
Candida albicans | CaO19.4297 | Casein kinase II, regulatory (beta-prime) subunit |
Candida albicans | CaO19.11773 | Casein kinase II, regulatory (beta-prime) subunit |
Candida albicans | CaO19.2102 | Casein kinase II, regulatory (beta) subunit |
Caenorhabditis elegans | CELE_T01G9.6 | Protein KIN-10, isoform A |
Cryptosporidium hominis | Chro.30219 | protein kinase Ck2-beta |
Cryptosporidium parvum | cgd3_3670 | putative protein kinase CK2 regulatory subunit CK2B1 |
Cryptosporidium parvum | cgd3_1850 | putative casein kinase II regulatory subunit; besthit Pf 23508244 |
Dictyostelium discoideum | DDB_G0284601 | hypothetical protein |
Drosophila melanogaster | Dmel_CG15224 | Casein kinase II beta subunit |
Drosophila melanogaster | Dmel_CG8914 | Casein kinase II beta2 subunit |
Echinococcus granulosus | EgrG_000924900 | casein kinase ii subunit beta |
Entamoeba histolytica | EHI_152350 | casein kinase II regulatory subunit family protein |
Entamoeba histolytica | EHI_030840 | casein kinase II regulatory subunit family protein |
Entamoeba histolytica | EHI_075700 | casein kinase II regulatory subunit family protein |
Echinococcus multilocularis | EmuJ_000924900 | casein kinase ii subunit beta |
Giardia lamblia | GL50803_7421 | Casein kinase II beta chain |
Homo sapiens | ENSG00000204435 | casein kinase 2, beta polypeptide |
Leishmania braziliensis | LbrM.35.5340 | protein kinase ck2 regulatory subunit, putative |
Leishmania donovani | LdBPK_365320.1 | Casein kinase II subunit beta, putative |
Leishmania infantum | LinJ.36.5320 | protein kinase ck2 regulatory subunit, putative |
Leishmania major | LmjF.36.5090 | protein kinase ck2 regulatory subunit, putative |
Leishmania mexicana | LmxM.36.5090 | protein kinase ck2 regulatory subunit, putative |
Loa Loa (eye worm) | LOAG_02447 | Csnk2b protein |
Mus musculus | ENSMUSG00000024387 | casein kinase 2, beta polypeptide |
Neospora caninum | NCLIV_034900 | casein kinase II beta chain, putative |
Neospora caninum | NCLIV_037540 | YOR039Wp-like protein, related |
Oryza sativa | 4349414 | Os10g0564900 |
Oryza sativa | 4343287 | Os07g0495100 |
Onchocerca volvulus | OVOC920 | Casein kinase II subunit beta homolog |
Onchocerca volvulus | OVOC915 | Casein kinase II subunit beta homolog |
Plasmodium berghei | PBANKA_0943200 | casein kinase II beta chain, putative |
Plasmodium berghei | PBANKA_1355500 | casein kinase II beta chain, putative |
Plasmodium falciparum | PF3D7_1342400 | casein kinase II beta chain |
Plasmodium falciparum | PF3D7_1103700 | casein kinase II beta chain |
Plasmodium knowlesi | PKNH_1259000 | casein kinase II beta chain, putative |
Plasmodium knowlesi | PKNH_0901300 | casein kinase II beta chain, putative |
Plasmodium vivax | PVX_090870 | casein kinase II beta chain, putative |
Plasmodium vivax | PVX_083020 | casein kinase II beta chain, putative |
Plasmodium yoelii | PY01577 | casein kinase ii beta chain |
Plasmodium yoelii | PY01939 | protein kinase Ck2-beta |
Saccharomyces cerevisiae | YOR039W | casein kinase 2 regulatory subunit CKB2 |
Saccharomyces cerevisiae | YGL019W | casein kinase 2 regulatory subunit CKB1 |
Schistosoma japonicum | Sjp_0021650 | ko:K03115 casein kinase 2, beta polypeptide, putative |
Schistosoma japonicum | Sjp_0203930 | ko:K03115 casein kinase 2, beta polypeptide, putative |
Schistosoma japonicum | Sjp_0049900 | Casein kinase II subunit beta, putative |
Schistosoma mansoni | Smp_025010 | casein kinase II beta subunit |
Schmidtea mediterranea | mk4.000967.04 | Casein kinase II subunit beta |
Schmidtea mediterranea | mk4.000448.08 | Casein kinase II subunit beta |
Trypanosoma brucei gambiense | Tbg972.11.12130 | protein kinase ck2 regulatory subunit, putative |
Trypanosoma brucei | Tb927.11.10820 | Casein kinase II subunit beta, putative |
Trypanosoma congolense | TcIL3000.11.11480 | Casein kinase II subunit beta, putative |
Trypanosoma cruzi | TcCLB.503757.40 | Casein kinase II subunit beta, putative |
Trypanosoma cruzi | TcCLB.509575.50 | Casein kinase II subunit beta, putative |
Toxoplasma gondii | TGME49_272400 | casein kinase ii regulatory subunit protein |
Toxoplasma gondii | TGME49_268810 | ck2 beta subunit |
Theileria parva | TP01_0881 | casein kinase II beta chain, putative |
Theileria parva | TP02_0584 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_314920 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_239910 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_297610 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_014300 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_281580 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_198920 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_230170 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_092690 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_109300 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_319200 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_100900 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_167560 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_488390 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_334200 | casein kinase II beta chain, putative |
Trichomonas vaginalis | TVAG_290850 | casein kinase II beta chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.2590 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2590 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2590 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.2590 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T01G9.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T01G9.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T01G9.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T01G9.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T01G9.6 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0943200 | Plasmodium berghei | Essential | plasmo |
TGME49_272400 | Toxoplasma gondii | Probably essential | sidik |
TGME49_268810 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | casein kinase 2, beta polypeptide | Compounds | References |
Homo sapiens | casein kinase 2, beta polypeptide | Compounds | References |